多發(fā)性骨髓瘤化療方案

1、化療方案骨髓瘤萬(wàn)案藥物劑量用法時(shí)間ABVD母28天周期阿霉素25mg/m2ivd1, 15博來(lái)霉素210mg/mivd1, 15長(zhǎng)春堿6mg/m2ivd1, 15達(dá)卡巴嗪375mg/m2ivd1, 15BACOP（*為加強(qiáng)方案）阿霉素25mg/m2 (*40mg/m2)或ivd1, 8母28天周期EPI 40mg/m2 (*50mg/m2)環(huán)磷酰胺2650mg/mivd1, 8長(zhǎng)春新堿21.4mg/mivd1, 8潑尼松40-60mg/m2pod15-28博來(lái)霉素10mg/m2ivd15, 22BEACOPP（*為加強(qiáng)方案）阿霉素25mg/m2 (*35mg/m2)ivd1每21天一周期環(huán)磷酰

2、胺650mg/m2 (*1250mg/m2)ivd1依托泊甘100mg/m2 (*200mg/m2)ivd1-3長(zhǎng)春新堿1.4mg/m (max 2mg/m )ivd8甲基芐肼2100mg/mpod1-7潑尼松40mg/m2pod1-14博來(lái)霉素210mg/mivd8dex-DEAM卡莫司汀260mg/mivd2美法侖220mg/mivd3依托泊甘2200mg/miv ,Q12hd4-7阿糖胞甘100mg/m2iv ,Q12hd4-7地塞米松8mgpo, tidd1-10mi ni-DEAM卡莫司汀260mg/mivd1美法侖30mg/m (max 50mg)ivd5依托泊甘75mg/m2iv

3、d2-5阿糖胞甘2100mg/miv ,Q12hd2-5CHOP14天或21天一阿霉素50mg/m2(或 EPI 80mg/m2)ivd1周期環(huán)磷酰胺2750mg/mivd1長(zhǎng)春新堿1.4mg/m2ivd1潑尼松100mgpod1-5CHOP-E每21天一周期阿霉素50mg/m2(或 EPI 80mg/m2)ivd1環(huán)磷酰胺2750mg/mivd1右 pk1.4mg/mivd1長(zhǎng)春新堿依托泊甘100mg/m2ivd1-3潑尼松100mgPod1-5CHOP-L-ASP每21天一周期阿霉素50mg/m2(或 EPI 80mg/m2)ivd1環(huán)磷酰胺2750mg/mivd1長(zhǎng)春新堿1.4mg/m2

4、 (max 2mg)ivd1潑尼松100mgpod1-5左旋門(mén)冬6000U/ivd1,3,7,9,11酰胺酶CEOP每21天一周期環(huán)磷酰胺500mg/m2ivd1依托泊甘237.5mg/mivd1長(zhǎng)春新堿2mgivd1潑尼松75mg/m2pod1-5COP每14-21天一周環(huán)磷酰胺750mg/m2ivd1期長(zhǎng)春新堿1.4mg/m (max 2mg)ivd1, 8潑尼松100mgpod1-5COPP母28天周期環(huán)磷酰胺600-800mgivd1, 8長(zhǎng)春新堿1.4mg/m2 (max 2mg)ivd1, 8丙卡巴肼2100mg/mpod1-14潑尼松40mg/m2pod1-14CVP每21天一周

5、期環(huán)磷酰胺2400mg/mivd1-5長(zhǎng)春新堿1.4 (max 2mg)ivd1潑尼松100mgpod1-5DDP-VP-16每21天周期順鉑230mg/mivd1-3 (水化）依托泊甘40-50mg/m2ivd5-10DHAP每14-21天一周順鉑100mg/m2ivd1期阿糖胞甘2g/m2iv ,Q12hd2地塞米松40mgivd1-4DICE每21天周期異環(huán)磷酰21000mg/mivd1-4胺順鉑25mg/m2ivd1-4依托泊甘260mg/mivd1-4地塞米松6-9mg/m2pod1-10EPOCH每21天周期阿霉素10mg/m2iv （連續(xù)d1-496h)依托泊甘50mg/m2iv

6、 （連續(xù)d1-496h)長(zhǎng)春新堿0.4mg/m2iv （連續(xù)d1-496h)環(huán)磷酰胺2750mg/mivd5潑尼松60mg/m2Pod1-5EPOCH每21天周期依托泊甘260mg/mivd1-4順鉑25mg/m2iv （連續(xù)d1-496h)甲潑尼龍500mg/m2ivd1-4阿糖胞甘2g/m2ivd5FC每28天周期氟達(dá)拉濱25-30mg/m2ivd1-3環(huán)磷酰胺2250-300mg/mivd1-3FCM每28天周期氟達(dá)拉濱225mg/mivd1-3米托蒽醌26-8mg/mivd1環(huán)磷酰胺2200mg/mivd1-3FCM每28天周期氟達(dá)拉濱25mg/m2ivd1-3米托蒽醌210mg/mi

7、vd1地塞米松20mgiv/pod1-5GDP每21天周期吉西他濱1000mg/mfivd1, 8順鉑275mg/mivd1地塞米松40mgivd1-4GemOx吉西他濱1000mg/mfivd1奧沙利鉑2100mg/mivd1ICE依托泊甘2100mg/mivd1-3異環(huán)磷酰5000mg/m?iv (24h胺輸注）d2卡鉑按 AUC=5, max800mgivd2IVE每21天周期表阿霉素250mg/mivd1異環(huán)磷酰3000mg/m?iv (22h)d1-3胺依托泊甘2200mg/miv (2h)d1-3MACOP-B每12周重復(fù)一阿霉素50mg/m2ivwk1,3,5,7.周期9,11環(huán)

8、磷酰胺2350mg/mivwk1,3,5,7,9,11匚 jTfIt21.4mg/m (max 2mg)ivwk2,4,6,8.長(zhǎng)春新堿10,12博來(lái)霉素210mg/mivwk4,8,12潑尼松75mg/dpowk1-11 后逐漸減量wk2,6,10MIMEMethy-2500mg/mivd1guazone異環(huán)磷酰1000mg/m2ivd1-5胺依托泊甘2100mg/mivd1-3甲氨蝶呤230mg/mivd3MOEP 每21天周期米托蒽醌匚 7rF(710mg1.4mg/m (max 2mg)ivivd1-3d1長(zhǎng)春新堿依托泊甘100mgivd1-5 (7)潑尼松60mgpod1-5 (7)

9、MOPP 每28天周期氮芥匚 7rF(76mg/m221.4mg/mivivd1, 8d1, 8長(zhǎng)春新堿丙卡巴肼2100mg/mpod1-14潑尼松40mg/m2pod1-14SMILE 每28天周期甲氨蝶呤2g/m2ivd1異環(huán)磷酰 胺21500mg/mivd2-4依托泊甘2100mg/mivd2-4地塞米松40mg/m2ivd2-4L-ASP6000U/m2ivd8,10,12,14,16,18,20HD-MTX甲氨蝶呤1-3giv (12h)d1HD-AraC阿糖胞甘3g/m2iv ,Q12hd1-3 (6)ABCM阿霉素30mg/m2ivd1卡莫司汀230mg/mivd1環(huán)磷酰胺210

10、0mg/mpod22-25美法侖26mg/mpod22-25DCEP地塞米松40mg/dIv/pod1-4環(huán)磷酰胺2400mg/miv,持續(xù)d1-4依托泊甘40mg/m2iv,持續(xù)d1-4順鉑210mg/miv,持續(xù)d1-4DT-PACE地塞米松40mg/div/pod1-4沙利度胺400mg/dpo維持阿霉素10mg/m2Ivd1-4順鉑210mg/miv,持續(xù)d1-4環(huán)磷酰胺2400mg/miv,持續(xù)d1-4依托泊甘40mg/m2iv,持續(xù)d1-4MP每4-6周一周期美法侖10mg/m2pod1-4潑尼松50mg/m2pod1-4M2美法侖8mg/m2pod1-4卡莫司汀220mg/miv

11、d1環(huán)磷酰胺長(zhǎng)春新堿400mg/m221.2mg/mivivd1d1潑尼松2 240mg/m ,20mg/mpod1-7,8-14PEDA順鉑220mg/mivd1-4依托泊甘100mg/m2ivd1-4地塞米松40mg/divd1-5阿糖胞甘1g/m2ivd5VAD長(zhǎng)春新堿0.4mg/m2ivd1-4阿霉素29mg/mivd1-4地塞米松40mgpod1-4,9-12,17-20LD雷利度胺25mg/dpod1-21地塞米松40mg/div/pod1-4,9-12,17-20LR雷利度胺25mg/dpo每月wks1-3利妥昔單 抗375mg/m2ivwks2-5,13-16L+DVD雷利度胺

12、10mg/dpod1-21脂質(zhì)體阿 霉素長(zhǎng)春新堿40mg/m22mgivivd1d1地塞米松40mg/dpod1-4L+MP雷利度胺5-10mg/dpod1-21美法侖0.18-0.25mg/kg/dpod1-4CTD潑尼松2mg/kg/dpod1-4沙利度胺200mgpod1-28環(huán)磷酰胺50mg/d,bidpod1-21MPT地塞米松50mg/d,Qodpod1-4,15-21沙利度胺100mg/dpod1-28美法侖4mg/m2pod1-7TD潑尼松40mg/m2pod1-7沙利度胺200mg/dpod1-28地塞米松40mg/dpod1-4,9-12,17-20 （奇數(shù)周期）TDD40

13、mg/dpod1-4 （偶數(shù)周期）沙利度胺100mg/dpod1-28脂質(zhì)體阿霉素240mg/mivd1TP地塞米松40mg/dpod1-4,9-12,17-20沙利度胺200mg/dpoQdVD潑尼松50mgpoQod硼替佐米21.3mg/mivd1,4,8,11VMP地塞米松40mg/divd1-4,9-12,17-20 （奇數(shù)周期）d1-4 （偶數(shù)周期）硼替佐米1.0-1.3mg/mFivd1,4,8,11,22,25,29,32美法侖9mg/mFivd1-4PDA潑尼松260mg/mpod1-4硼替佐米1.3mg/m2ivd1,4,8,11阿霉素20,4,5,9mg/mivd1-4地塞米松40mg/div第1周期：d1-4,8-11,15-18 第2-4周期：d1-4VTD硼替佐米21.3mg/mivd1,4,8,11