苯扎氯銨培訓(xùn)講學(xué)

1、苯扎氯銨bn zh l nBenzalkonium Chloride本品為氯化二甲基芐基烴銨的混合物。按無(wú)水物計(jì)算，含烴銨鹽（C22H40CI N）應(yīng)為 95.0105.0。This product is the mixture of dimethyl benzyl ammonium chloride. Calculation by anhydrous, the C22H40CIN content shall be 95.0105.0.【性狀】本品為白色蠟狀固體或黃色膠狀體；水溶液顯中性或弱堿性反應(yīng)，振搖時(shí)產(chǎn)生多量泡沫。本品在水或乙醇中極易溶解，在乙醚中微溶。Shape and propert

2、ies:This product is a white waxy solid or yellow jelly; water solution is neutral or weak alkaline reaction, when shaking, a lot of foam will produce.This product is easy to dissolve in water or ethanol, slightly soluble in ether.【鑒別】 (1) 取本品約0.2g，加硫酸1ml使溶解，加硝酸鈉0.1g，置水浴上加熱 5分鐘，放冷，加水10ml與鋅粉0.5g，置水浴上溫

3、熱5 分鐘，取上清液2ml，加5亞硝 酸鈉溶液1ml，置冰水中冷卻，再加堿性萘酚試液3ml ，即顯猩紅色。(2) 取本品，加水制成每1ml中含0.5mg的溶液，照分光光度法（附錄 A）測(cè)定， 在257nm，262nm及269nm 的波長(zhǎng)處有最大吸收。(3) (3) 取本品1 水溶液10ml，加稀硝酸0.5ml，即發(fā)生白色沉淀，濾過(guò)，沉淀能在乙醇中溶解，濾液顯氯化物的鑒別反應(yīng)（附錄）。Identification:(1) Taking this product about 0.2g, with 1ml of sulfuric acid dissolving, adding sodium nitr

4、ate 0.1g, heating on the water bath for 5 minutes, adding 10ml and zinc powder 0.5g, water bath for 5 minutes, take the supernatant 2ml, adding 5% sodium nitrite solution 1ml, cooling in water, add alkaline naphthol solution 3ml, then scarlet will show.(2) Take this product, add water to make a solu

5、tion containing 0.5mg per 1ml, according to the spectrophotometric method (Appendix IV A), at 257nm, 262nm and 269nm at the wavelength of maximum absorption.(3) Take this product 1% aqueous solution 10ml, add dilute nitric acid 0.5ml, that is, white precipitate, filtration, precipitation can be diss

6、olved in ethanol, the reaction of chloride in the filtrate (Appendix III).【檢查】酸堿度：取本品0.5g，加水50ml使溶解，加溴甲酚紫溶液（取溴甲酚紫50m g，加0.1mol/L氫氧化鈉溶液0.92ml與乙醇20ml使溶解，加水稀釋至100ml） 0.1ml，若溶液顯黃色，用氫氧化鈉滴定液（0.1mol/L）滴定；若溶液顯藍(lán)紫色，用鹽酸滴定液（0.1mol/L）滴定，消耗的滴定液均不得過(guò)0.1ml。溶液的澄清度與顏色：取本品1.0g，加新沸放冷的水100ml使溶解，溶液應(yīng)澄清無(wú)色；如顯渾濁，與1號(hào)濁度標(biāo)準(zhǔn)液（附錄B）

7、比較，不得更濃；如顯色，與黃色2號(hào)標(biāo)準(zhǔn)比色液（附錄 A第一法）比較，不得更深。水不溶物：取本品1.0g，加水10ml溶解后，不得顯渾濁，不得有不溶物。 氨化合物：取本品0.1g，加水5ml溶解后，加氫氧化鈉試液3ml，加熱煮沸， 不得發(fā)生氨臭。水分：取本品，照水分測(cè)定法（附錄 M第一法A）測(cè)定，含水分不得過(guò)10.0%。熾灼殘?jiān)喝”酒?.0g，依法檢查（附錄 N），遺留殘?jiān)坏眠^(guò)0.1%。Check:PH: take this product 0.5g, 50ml water to dissolve, with bromocresol purple solution (take bromocr

8、esol purple 50mg, plus 0.1mol/L 0.92ml 20ml sodium hydroxide solution and ethanol dissolved, diluted with water to 100ml 0.1ml), if the solution is yellow, with sodium hydroxide titration solution (0.1mol/L) titration; if the solution is blue purple, with hydrochloric acid titration solution (0.1mol

9、/L) titration, titration solution consumption shall be exceeding 0.1ml.Clarity and color of solution: take this product 1.0g, add new boiled water 100ml to dissolve, the solution should be clear and colorless; significant turbidity, and 1 turbidity standard solution (Appendix B), must not be thicker

10、; such as color, and Yellow No. 2 standard colorimetric solution (appendix the first method is A), shall not be deeper.Water insoluble: take this product 1.0g, add water 10ml dissolved, shall not be muddy, no insoluble matter.Ammonia compounds: take this product 0.1g, 5ml of water dissolved, adding

11、sodium hydroxide solution 3ml, boiling, no ammonia smell.Water content: take this product, according to the determination of moisture content (Appendix VIII M A) determination of water containing not more than 10%.Residue: take this product 1.0g, according to inspection (Appendix VIII N), legacy res

12、idue shall not exceed 0.1%.【含量測(cè)定】取本品約0.5g，精密稱定，置燒杯中，用水35ml分次洗入250ml 分液漏斗中，加0.1mol/L氫氧化鈉溶液10ml與氯仿25ml，精密加入新制的5碘化鉀溶液 10ml，振搖，靜置使分層，水層用氯仿提取3次，每次10ml，棄去氯仿層，水層移入 250ml具塞錐形瓶中，用水約15ml分3次淋洗分液漏斗，合并洗液與水液，加鹽酸40ml，放冷，用碘酸鉀滴定液(0.05mol/L) 滴定至淡棕色，加氯仿5ml，繼續(xù)滴定并劇烈振搖至氯仿層無(wú)色，并將滴定的結(jié)果用空白試驗(yàn)校正。每1ml碘酸鉀滴定液(0.05 mol/L) 相 當(dāng)于35.4

13、0mg 的C22H40CIN 。Content determination:Take this product about 0.5g, precision said, the beaker of water washed into 35ml 250ml separatory funnel, plus 0.1mol/L 10ml sodium hydroxide solution and chloroform 25ml, adding 5% 10ml of potassium iodide solution precision, the newsystem of shaking, the sta

14、tic water stratification, extracted 3 times with chloroform, 10ml each time, abandoned go to the chloroform layer layer into 250ml conical flask with stopper, water is about 15ml 3 times leaching separation funnel with lotion and liquid water, hydrochloric acid 40ml, put cold with potassium iodate titration solution (0.05mol/L) titration to light brown, add chloroform and 5ml, and continue the titration vigorous shaking to chloroform layer of colorless then, the titration correction by blank tes