《免疫學(xué)導(dǎo)論》教學(xué)大綱

1、免疫學(xué)導(dǎo)論教學(xué)大綱課程名稱：免疫學(xué)導(dǎo)論 英文名稱： The leading of immunology課程性質(zhì)：專業(yè)課程課程編號：所屬系部：生命科學(xué)系 周 學(xué) 時：3學(xué)時總 學(xué) 時：55學(xué)時（講授37，文獻閱讀與報告6，實驗12）學(xué)分： 教學(xué)對象（本課程適合的專業(yè)和年級）：生物技術(shù)專業(yè)（本科）生物制藥方向三年級學(xué)生 生物科學(xué)專業(yè)（本科）三年級學(xué)生預(yù)備知識：生物化學(xué)、微生物學(xué)基礎(chǔ)知識課程在教學(xué)計劃中的地位作用：免疫學(xué)及免疫生物制品是生物技術(shù)專業(yè)方向課程。通過本課程的學(xué)習(xí)，掌握免疫學(xué)的基本原理及免疫學(xué)基本實驗方法，為學(xué)生在生物制藥方面的就業(yè)和進行動物免疫學(xué)方面的研究打下堅實的理論基礎(chǔ)和技術(shù)基礎(chǔ)。教

2、學(xué)方式：講授與實驗相結(jié)合教學(xué)的目的與要求：本科程要求學(xué)生通過學(xué)習(xí)免疫的概念、免疫系統(tǒng)的組成、免疫分子和免疫細胞、免疫應(yīng)答的調(diào)節(jié)和免疫效應(yīng)機制，掌握免疫學(xué)的基本理論和基礎(chǔ)知識，為生物制藥專業(yè)方向的學(xué)生進一步學(xué)習(xí)其他專業(yè)課打下堅實的理論基礎(chǔ)，將免疫學(xué)的基礎(chǔ)理論和實驗技術(shù)應(yīng)用到該專業(yè)的其他學(xué)科。免疫學(xué)及免疫生物制品是一門實踐性很強的實驗科學(xué),要求在教學(xué)中充分重視實驗課，使學(xué)生初步掌握研究免疫學(xué)及免疫生物制品的基本方法與實驗技術(shù)，培養(yǎng)嚴謹?shù)目茖W(xué)態(tài)度、創(chuàng)新精神與分析問題和解決問題的能力。課程教材：于善謙，王洪海等，免疫學(xué)導(dǎo)論，高等教育出版社參考教材：龔非力主編，醫(yī)學(xué)免疫學(xué)，科學(xué)出版社，2004年Roit

3、t Brostoff, Male ：Immunology，人民衛(wèi)生出版社，2002年周德慶，微生物學(xué)（第二版），北京，高等教育出版社，2002年 編寫日期：2006年6月制定課程內(nèi)容及學(xué)時分配：第一章 Proface（2學(xué)時）通過本章的課堂教學(xué)，引導(dǎo)學(xué)生了解免疫學(xué)的由來與發(fā)展，什么是免疫，及免疫學(xué)的幾個基本概念，明確免疫學(xué)作為一門獨立學(xué)科在生命科學(xué)發(fā)展中的重要作用和地位，在維護人類健康和生產(chǎn)品質(zhì)優(yōu)良的動物產(chǎn)品的重要作用，展望未來，激發(fā)學(xué)生的學(xué)習(xí)興趣和明確肩負的重任。教學(xué)內(nèi)容：一、The development of immunology1.The infectious disease and

4、immunity2.The emergence and development of the immunology3.The development of the immunology in the modern times 二、The conception of the immunology1.The congenital and acquired immunity2.Immune response3.Immunology and the application practice4.The branch science and the development of the immunolog

5、y重點：The developed history of the immunology，The conception of the immunology，The character of the immune response, The significance , characteristic and relation of the congenital and acquired immunity.難點：The conception of the immunology and the character of the immune response第二章 Antigen（4.5學(xué)時）通過本章

6、的課堂教學(xué)，向?qū)W生介紹抗原的基本概念、抗原的分子基礎(chǔ)及抗原的特性，使他們了解現(xiàn)實生活中常見的各種微生物抗原及疫苗的種類。教學(xué)內(nèi)容：一、The basic conception and the categories of the antigen1.Antigen and immunity 2.Categories of antigen二、The molecular basis of the antigen1.The chemical character of the antigen2.The Determinant of the antigen三、The immunogenicity of th

7、e antigen1.The ectogenisis of the antigen2.The relationship of the immunogenicity and the individual,the method of immunity.3.The specificity and immune dominant4.The immune specificity of the hepten四、The infectivity of the antigen1.Bacteria2.Fungi3.Virus五、Vaccine1.The common caccine2.The recombinat

8、ed live vaccine3.Polypeptide vaccine4.DNA vaccine重點：The conception and basic character of the antigen難點：The categories of infectious antigen and vaccine which can cause the diseases of human and animal.第三章 Antibody（2.5學(xué)時）通過本章的課堂教學(xué)，向?qū)W生介紹抗體的概念及其結(jié)構(gòu)，并讓學(xué)生了解抗體的合成和分泌過程。了解抗體的多樣性。教學(xué)內(nèi)容：一、The structure and cat

9、egories of the immunoglobulin1.The basic constructure of the antibody2.The categories of the immunoglobulin二、The genes of the immunoglobulin1.The gene stucture of the immunoglobulin2.The recombination and expression of the immunoglobulin3.The genes diversity of the immunoglobulin三、The synthesis and

10、secretion of the immunoglobulin1.The humoral immune response and the antibody production2.The Expression, resemble and secresion of the immunoglobulin 重點：The structure and categories of the immunoglobulin,The humoral immune response and the antibody production 難點：The genes of immunoglobulin第四章 Compl

11、ement system （3學(xué)時）通過本章的教學(xué)，讓學(xué)生了解動物補體組成及其理化性質(zhì)，掌握補體活化的基本途徑，了解補體的生物學(xué)效應(yīng)及其補體缺陷引發(fā)的各種病癥。教學(xué)內(nèi)容：一、The composition and physics-chemical specificity of the complement1.Naming of the complement component2.The composition and physics-chemical specificityof the complement二、The complement activation1.The classical a

12、ctivated pathway of the complement2.The lectin activated pathway of the complement3.The alternative activated pathway of the complement4.The formation of membrane lysis complex in the later stageof the complement activaion5.The comparison of the 3 complement activated pathway.三、The modulation and th

13、e biological effect of the complement.1.The regulated protein which activate complement in the serum.2.The regulated protein on the cyto-membrane.3.The receptor of the complement.4.The biological function of the complement protein.四、The biological synthesis and deficiency of the complement1.The comp

14、lement gene.2.The biological synthesis of the complement.3.The deficiency and defective diseases of the complement.重點：The composition and biological function of the complement system, 3 complement activated pathways.難點：The basic 3 pathway of the complement activation.第五章 The cells,tissues and organs

15、 of the immune system（3學(xué)時）通過本章的學(xué)習(xí)，讓學(xué)生了解動物體淋巴組織器官的結(jié)構(gòu)和功能，掌握免疫細胞的種類。教學(xué)內(nèi)容：一、The structure and function of the lymph tissues and organs.1.The composition and the function of the primary lymph organs.2.The composition and the function of the secondary lymph organs.3.The circulation of the lymphocytes.二、Th

16、e cells of the immune system1.B cells2.T cells3.The natural killer cells and the natural suppress cells.4.phagcytosis cells, granular cells and the mast cells.5.Langhans' cells and the dendritic cells.重點：The composition and the function of the primary and secondary lymph organs, the categories a

17、nd specificity of the immune cells.難點：The origination and surface marker of the immune cells.第六章 The major histocompatibility complex,MHC（2學(xué)時）通過本章的課堂教學(xué)，讓學(xué)生掌握兩種主要組織相容性抗原的結(jié)構(gòu)與功能，了解MHC的檢測原理及應(yīng)用。教學(xué)內(nèi)容：一、The composition and the function ofthe major histocompatibility antigen.1.Class I major histocompatibili

18、ty antigen molecule.2.Class II major histocompatibility antigen molecule.3.The binding stuctural basis of the peptide and MHC molecule.二、The gene stucture and heredity of the major histocompatibility antigen1.Genetics and polymorphism of MHC.2.The MHC gene stucture of mice.3.The MHC gene stucture of

19、human.三、The detected rational and application of the MHC.1.The detection of HLA1 antigen.2.The detection of HLA2 antigen.3.The method of HLA gene steretype.4.The application of HLAs detection.重點：The composition and specificity ofthe major histocompatibility antigen. The methods and significance of t

20、he HLA detection.難點：The gene stucture of MHC.第七章 The reaction and application of antigen and antiboy （4學(xué)時）通過本章的課堂教學(xué)，使學(xué)生了解不同抗體的制備過程，抗原抗體的反應(yīng)原理，及與抗體有關(guān)的常見的免疫學(xué)分析方法。教學(xué)內(nèi)容：一、Preparation of antibody1.Preparation of anti-serum2. preparation of monoclonal antibody3.preparation of genetic engineered antibody4.p

21、reparing the catalytic antibody 二、The principl of antibody-antigen response1.The thermodynamics and dynamics of anitigen-antibody response .2.The reaction of antibody with single valued antigen.3.The reaction of antibody with macromolecular multi-valued antigen三、The common immune analytical method1.

22、immunoprecipitation2.immune marking3. immune localization4.The other applications antigen-antibody response 重點：The precesses of preparation of anti-serum and monoclonal antibody. The priciple of antigen and antibody reaction.難點：The common immune analytical method.第八章 cell mediated immune response （4

23、學(xué)時）通過本章的課堂教學(xué)，使學(xué)生了解什么是免疫應(yīng)答及免疫應(yīng)答的特性，掌握免疫應(yīng)答的基本過程，了解什么是細胞凋亡及細胞凋亡與免疫之間的關(guān)系。教學(xué)內(nèi)容：一、The basic conception of immune responses1.the non-specific and specificity of immune response.2.The active immunization, passive immunization and passive immunity.3.Non-response.二、The basic process of the immune responses1.a

24、ntigen-presenting cells.2.T cell activation.3.The immune response of exogenous antigens.4.The immune response of endogenous antigen .三、Cell Apoptosis and immunity1.the characters of apoptosis2.the detection of apoptosis3. apoptosis and immunity重點：The characters and categories of the immune response.

25、The basic principle of antigen presenting.難點：The basic principle of antigen presenting.The relationship of cell apoptosis and immunity.第九章 Immune regulation（4學(xué)時）通過本章的課堂教學(xué)，使學(xué)生抗原、抗體及免疫細胞和細胞介素等對免疫應(yīng)答的調(diào)節(jié)，了解免疫耐受形成的原因及其調(diào)節(jié)途徑。教學(xué)內(nèi)容：一、The regulation of antigen, antibody to the immune response1.the regulation o

26、f antigen2.the regulation of antibody3.The immune network regulative effection of the idiotype and the anti-idiotype 二、The regulation of immune cells to the immune response1.the immune regulation of T cells 2.the immune regulation of other cells.三、The cytokine and immune regulation1.The catagories o

27、f the erleukin3.The other cytokines produced by the T cells四、Immunologic tolerance1.The finding of the immunologic tolerance2.The regulation and inducing pathway of the formation of immunologic tolerance 3.The mechanism of immune tolerance重點：The immune regulation on the level of molecu

28、le and cell,The immune regulation of idiotype network,The principle of the immune tolerance.難點：The immune regulation of idiotype network第十章 Hypersensitivity（3學(xué)時）通過本章的課堂教學(xué)，使學(xué)生了解什么是超敏反應(yīng)及幾種超敏反應(yīng)發(fā)生的原因和損傷機制、典型癥狀。教學(xué)內(nèi)容：一、Type-I hypersensitivity1. The initiating mechanism of the type-I hypersensitivity.2. Th

29、e allergen of the type-I hypersensitivity3. The IgE and IgE receptor4. The common diseases caused by type-I hypersensitivity二、Type-II hypersensitivity1. The injury mechanism of type-II hypersensitivity2. Type-II hypersensitivity and the dieases三、Type-III hypersensitivity1. The reason of type-III hyp

30、ersensitivity2. The common dieases caused by the immune complex四、Type- hypersensitivity（delayed type hypersensitivity）1.delayed type hypersensitivity2.The interaction of the cells in the DTH3.The commun diseases caused by theType- hypersensitivity重點：超敏反應(yīng)的概念、各型超敏反應(yīng)的特點及發(fā)生機制難點：各型超敏反應(yīng)的特點及防治方法。第十一章 The a

31、lloimmune response（3.5學(xué)時）通過本章的課堂教學(xué)，使學(xué)生了解幾種異常免疫應(yīng)答及動物體存在的免疫缺陷，激發(fā)學(xué)生研究異常免疫應(yīng)答的興趣，探討對異常免疫應(yīng)答的防治措施。教學(xué)內(nèi)容：一、The autoimmune response：conception1.the occurrence reason of the autoimmune response2.autoimmune disease二、Transplantation immunity1.The types of transplantation and the immune response of allotype grafting2.Transplantation antigen and immunity3.the pathway of redu