Tetracycline-hydrochloride _Bacterial 抑制劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemETetracycline hydrochlorideCat. No.: HY-B0474CAS No.: 64-75-5分式: CHClNO分量: 480.9作靶點(diǎn): Bacterial作通路: Anti-infection儲(chǔ)存式: Powder -20C 3 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 62.5 mg/mL (129.96 mM; Need ultrasonic)

2、H2O : 50 mg/mL (103.97 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 2.0794 mL 10.3972 mL 20.7943 mL5 mM 0.4159 mL 2.0794 mL 4.1589 mL10 mM 0.2079 mL 1.0397 mL 2.0794 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Tetracycline (hydrochloride)種譜抗素，對(duì)多種蘭陽性

3、和蘭陰性細(xì)菌有抑制活性。體外研究Tetracyclines are broad-spectrum agents, exhibiting activity against a wide range of gram-positive and gram-negative bacteria, atypical organisms such as chlamydiae, mycoplasmas, and rickettsiae, and protozoanparasites. Tetracyclines inhibit bacterial protein synthesis by preventing

4、the association of aminoacyl-tRNAwith the bacterial ribosome. Tetracyclines traverse the outer membrane of gram-negative enteric bacteriathrough the OmpF and OmpC porin channels, as positively charged cation (probably magnesium)-1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEtetracycline coordinat

5、ion complexes 1.體內(nèi)研究 The tetracyclines have applications for the treatment of infections in poultry, cattle, sheep, and swine. Insome cases, e.g., for therapeutic treatment of large numbers of poultry reared on commercial farms, theantibiotics are added directly to feed or water or can be administer

6、ed in aerosols. Tetracyclines could beused as growth promotion or growth enhancement. Tetracyclines are used in aquaculture to controlinfections in salmon, catfish, and lobsters 2.戶使本產(chǎn)品發(fā)表的科研獻(xiàn) Chemosphere. 2019 Mar.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Chopra I, et al.Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology ofbacterial resistance.MicrobiolMol Biol Rev. 2001 Jun;65(2):232-60McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only