Niraparib-metabolite-M1-Niraparib-carboxylic-acid-metabolite-M1-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemENiraparib metabolite M1Cat. No.: HY-G0023CAS No.: 1476777-06-6Synonyms: Niraparib carboxylic acid metabolite M1; M1 metabolite ofniraparib分式: CHNO分量: 321.37作靶點(diǎn): Drug Metabolite作通路: Metabolic Enzyme/Protease儲(chǔ)存式: Powder -20C 3 yea

2、rs4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 100 mg/mL (311.17 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 3.1117 mL 15.5584 mL 31.1168 mL5 mM 0.6223 mL 3.1117 mL 6.2234 mL10 mM 0.3112 mL 1.5558 mL 3.1117 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑

3、配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前?qǐng)先配制澄清的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.75 mg/mL (8.56 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline

4、)1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemESolubility: 2.75 mg/mL (8.56 mM); Clear solution3. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.75 mg/mL (8.56 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Niraparib metabolite M1niraparib 的代謝物。Niraparib 種新穎的 PARP 抑制劑。體外研究 Niraparib metabolite M1 has t

5、he validation in plasma and urine for the support of clinical studies such as themass balance study and the absolute bioavailability study 1.REFERENCES1. van Andel L, et al. Liquid chromatography-tandem mass spectrometry assay for the quantification of niraparib and its metabolite M1 inhuman plasma and urine. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Nov 19;1040:14-21McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;