Icilin-AG-3-5-DataSheet-生命科學試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEIcilinCat. No.: HY-11062CAS No.: 36945-98-9Synonyms: AG-3-5分式: CHNO分量: 311.29作靶點: TRP Channel作通路: Membrane Transporter/Ion Channel; Neuronal Signaling儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數據體外實

2、驗 DMSO : 54 mg/mL (173.47 mM)H2O : 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (8.03 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 IcilinTRPM8離通道激動劑。REFERENCES1. Lee S, et al. Icilin inhibits E2F1-mediated cell cycle regulatory programs in pros

3、tate cancer. Biochem Biophys Res Commun. 2013 Nov29;441(4):1005-10.2. Andersson DA, et al. TRPM8 activation by menthol, icilin, and cold is differentially modulated by intracellular pH. J Neurosci. 2004 Jun9;24(23):5364-9.3. Kim J, et al. Icilin-evoked behavioral stimulation is attenuated by alpha-a

4、drenoceptor activation. Brain Res. 2011 Apr 12;1384:110-7.4. Kim SH, et al. Icilin induces G1 arrest through activating JNK and p38 kinase in a TRPM8-independent manner. Biochem Biophys ResCommun. 2011 Mar 4;406(1):30-5.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax: 021-