XP-59-DataSheet-生命科學試劑-生命科學試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?Agonists?ScreeningLibrarieswww.MedChemEXP-59Cat.No.:HY-136284CASNo.:890402-73-0分?式:C??H??N?O?分?量:282.3作?靶點:SARS-CoV作?通路:Anti-infection儲存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實驗DMSO:62.5mg/mL(221.40mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM3.5423mL17.7117mL35.4233mL5mM0.7085mL3.5423mL7.0847mL10mM0.3542mL1.7712mL3.5423mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存?式和期限。體內實驗請根據(jù)您的實驗動物和給藥?式選擇適當?shù)娜芙?案，配制前請先配制澄的儲備液，再依次添加助溶劑(為保證實驗結果的可靠性，體內實驗的?作液，建議您現(xiàn)?現(xiàn)配，當天使?；澄的儲備液可以根據(jù)儲存條件，適當保存；以下溶劑前的百分?指該溶劑在您配制終溶液中的體積占?)：1.請依序添加每種溶劑：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥6.25mg/mL(22.14mM);Clearsolution2.請依序添加每種溶劑：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥6.25mg/mL(22.14mM);Clearsolution3.請依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥6.25mg/mL(22.14mM);Clearsolution1/2MasterofSmallMolecules—您?邊的抑制劑?師www.MedChemEBIOLOGICALACTIVITY?物活性XP-59有效的SARS-CoVMpro抑制劑，其Ki值為0.1nM。IC50&TargetKi:0.1nM(SARS-CoVMpro)[1].體外研究TheSARS-CoVmainproteinase(Mpro)playsacentralroleintheformationoftheviralreplicase/transcriptasecomplexandisthusanidealtargetforthedevelopmentofsuitabledrugs[1].REFERENCES[1].VerschuerenKH,etal,.AstructuralviewoftheinactivationoftheSARScoronavirusmainproteinasebybenzotriazoleesters.ChemBiol.2008Jun;15(6):597-606.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-58955