Stafia-1-dipivaloyloxymethyl-ester-DataSheet-生命科學試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEStafia-1-dipivaloyloxymethylesterCat.No.:HY-136568CASNo.:2582755-72-2分?式:C??H??FO??P分?量:750.74作?靶點:STAT作?通路:JAK/STATSignaling;StemCell/Wnt儲存?式:Pureform-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實驗DMSO:100mg/mL(133.20mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM1.3320mL6.6601mL13.3202mL5mM0.2664mL1.3320mL2.6640mL10mM0.1332mL0.6660mL1.3320mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲存時，請在6個?內使?，-20°C儲存時，請在1個?內使?。體內實驗請根據(jù)您的實驗動物和給藥?式選擇適當?shù)娜芙?案。以下溶解?案都請先按照InVitro?式配制澄的儲備液，再依次添加助溶劑：(為保證實驗結果的可靠性，澄的儲備液可以根據(jù)儲存條件，適當保存；體內實驗的?作液，建議您現(xiàn)?現(xiàn)配，當天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的?式助溶)1.請依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥2.5mg/mL(3.33mM);Clearsolution1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEBIOLOGICALACTIVITY?物活性Stafia-1-dipivaloyloxymethylester(compound27)有效的、選擇性的STAT5a抑制劑。IC50&TargetSTAT5a體外研究Stafia-1-dipivaloyloxymethylester(compound27,0-200μM)decreasespSTAT5aexpressionsignificantly,andhasnoobviousinhibitiononpSTAT5b[1].WesternBlotAnalysis[1]CellLine:STAT5a-GFP-transfectedK562cells.Concentration:0-200μM.IncubationTime:Result:DecreasedpSTAT5aexpression.REFERENCES[1].KalaiselviNatarajan,etal.Stafia-1:ASTAT5a-SelectiveInhibitorDevelopedviaDocking-BasedScreeningofinSilicoO-PhosphorylatedFragments.Chemistry.2020Jan2;26(1):148-154.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-589