Bupropion-morpholinol-Hydroxy-Bupropion-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEBupropionmorpholinolCat.No.:HY-12766CASNo.:357399-43-0Synonyms:HydroxyBupropion分?式:C??H??ClNO?分?量:255.74作?靶點(diǎn):DopamineTransporter;nAChR作?通路:NeuronalSignaling;MembraneTransporter/IonChannel儲存?式:-20°C,sealedstorage,awayfrommoisture*Insolvent:-80°C,6months;-20°C,1month(sealed

storage,awayfrommoisture)溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:20mg/mL(78.20mM;Needultrasonicandwarming)Ethanol:20mg/mL(78.20mM;Needultrasonicandwarming)MassSolvent1mg5mg10mgConcentration制備儲備液1mM3.9102mL19.5511mL39.1022mL5mM0.7820mL3.9102mL7.8204mL10mM0.3910mL1.9551mL3.9102mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month(sealedstorage,awayfrommoisture)。-80°C儲存時(shí)，請?jiān)?個(gè)?內(nèi)使?，-20°C儲存時(shí)，請?jiān)?個(gè)?內(nèi)使?。BIOLOGICALACTIVITY?物活性Bupropionmorpholinol(HydroxyBupropion)Bupropion的主代謝物。Bupropionmorpholinol在體外抑制多巴胺、去甲腎上腺素轉(zhuǎn)運(yùn)蛋?和α4β2煙堿受體。Bupropionmorpholinol有助于抗抑郁和戒煙活動(dòng)。1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEIC50&TargetDopaminetransporter[2],Norepinephrinetransporter[2],α4β2nicotinicreceptor[2]體外研究BupropionmorpholinolisproducedfromBupropionbythegeneticallypolymorphicenzymeCYP2B6invivo[1].Bupropionmorpholinolinhibits[3H]norepinephrineuptakewithanIC50of1.7μM[2].REFERENCES[1].ZhuAZX,et,al.CYP2B6andbupropion'ssmoking-cessationpharmacology:theroleofhydroxybupropion.ClinPharmacolTher.2012Dec;92(6):771-7.[2].DamajMI,et,al.Enantioselectiveeffectsofhydroxymetabolitesofbupropiononbehaviorandonfunctionofmonoaminetransportersandnicotinicreceptors.MolPharmacol.2004Sep;66(3):675-82.[3].DamajMI,et,al.Effectsofhydroxymetabolitesofbupropiononnicotinedependencebehaviorinmice.JPharmacolExpTher.2010Sep1;334(3):1087-95.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-82