CM03-DataSheet-生命科學試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemECM03Cat.No.:HY-121862CASNo.:2101208-44-8分?式:C??H??N?O?分?量:632.75作?靶點:DNA/RNASynthesis作?通路:CellCycle/DNADamage儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性CM03?種有效的DNAG四聯(lián)體(G4s)結(jié)合分?。CM03可以穩(wěn)定G4s，下調(diào)更多含G4的因，并增加由于DNA和染?質(zhì)結(jié)構(gòu)扭轉(zhuǎn)應(yīng)變導致的雙鏈斷裂事件(DSBs)的發(fā)?率。CM03對胰腺癌細胞具有選擇性作?。IC50&TargetDNAsynthesis[1]體外研究CM03(0.4μM;24or48h)increasesthelevelofγ-H2AXproteinwhenincombinationwithSAHA(HY-10221)inMIAPaCa-2andPANC-1[1].CM03(0-100nM;96h)exhibitshighlyanti-proliferativeactivityagainstpancreaticcancercelllines[2].WesternBlotAnalysis[1]CellLine:MIAPaCa-2andPANC-1Concentration:0.4μMIncubationTime:24hforMIAPaCa-2,48hforPANC-1Result:Significantlyincreasedthelevelofγ-H2AXproteinwhenincombinationwithSAHA(HY-10221)(1μM).CellProliferationAssay[2]CellLine:MIAPaCa-2,PANC-1,Capan-1andBxPC-3Concentration:0-100nM1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEIncubationTime:96hResult:Exhibitedhighlyanti-proliferativeactivityagainstpancreaticcancercelllineswithGI50sof9.0nM,15.6nM,26.5nMand15.5nMinMIAPaCa-2,PANC-1,Capan-1andBxPC-3,respectively.REFERENCES[1].AhmedAA,etal.AG-Quadruplex-BindingSmallMoleculeandtheHDACInhibitorSAHA(Vorinostat)ActSynergisticallyinGemcitabine-SensitiveandResistantPancreaticCancerCells.Molecules.2020Nov19;25(22):5407.[2].AhmedAA,etal.AsymmetricallySubstitutedQuadruplex-BindingNaphthaleneDiimideShowingPotentActivityinPancreaticCancerModels.ACSMedChemLett.2020Jul16;11(8):1634-1644.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;