Abeprazan-hydrochloride-DWP14012-hydrochloride-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEAbeprazanhydrochlorideCat.No.:HY-109079ACASNo.:1902954-87-3Synonyms:DWP14012hydrochloride;Fexuprazanhydrochloride分?式:C??H??ClF?N?O?S分?量:446.87作?靶點(diǎn):ProtonPump作?通路:MembraneTransporter/IonChannel儲存?式:-20°C,sealedstorage,awayfrommoisture*Insolvent:-80°C,6months;-20°C,1month(sealed

storage,awayfrommoisture)溶解性數(shù)據(jù)體外實驗DMSO:100mg/mL(223.78mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM2.2378mL11.1889mL22.3779mL5mM0.4476mL2.2378mL4.4756mL10mM0.2238mL1.1189mL2.2378mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month(sealedstorage,awayfrommoisture)。-80°C儲存時，請在6個?內(nèi)使?，-20°C儲存時，請在1個?內(nèi)使?。BIOLOGICALACTIVITY?物活性Abeprazan(DWP14012)hydrochloride?種鉀競爭性酸(potassium-competitiveacid)阻滯劑。Abeprazanhydrochloride通過可逆的鉀競爭性離?結(jié)合抑制H+，K+-ATPase，??需酸激活。Abeprazanhydrochloride?種潛在的質(zhì)?泵抑制劑，?于研究與酸相關(guān)的疾病。體外研究ThemechanismofactionofAbeprazanhydrochlorideisreversiblybindingtoH+,K+1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE‐ATPase,and,unlikethatofPPIs,doesnotrequireacidicenvironmentfordrugactivation[1].體內(nèi)研究Abeprazanhydrochloride(DWP14012hydrochloride)inhibitsacidsecretioninadose-dependentmannerandtheinhibitionofgastricacidsecretionisequaltoorgreaterthanthatofvonoprazan,apreviouslyapprovedP-CAB,invariousinvivostudiesusingpylorus-ligatedrats,lumen-perfusedratmodelsandheidenhainpouchdogmodels[1].REFERENCES[1].SunwooJ,etal.Safety,tolerability,pharmacodynamicsandpharmacokineticsofDWP14012,anovelpotassium-competitiveacidblocker,inhealthymalesubjects.AlimentPharmacolTher.2018Jul;48(2):206-218.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-37