γ-Linolenic-Acid-methyl-ester-Methyl-GLA-DataSheet-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEγ-LinolenicAcidmethylesterCat.No.:HY-W009276CASNo.:16326-32-2Synonyms:MethylGLA分?式:C??H??O?分?量:292.46作?靶點:Apoptosis作?通路:Apoptosis儲存?式:Pureform-20°C3years4°C2yearsInsolvent-80°C6months-20°C1monthBIOLOGICALACTIVITY?物活性γ-LinolenicAcidmethylester(MethylGLA)γ-亞?酸(GLA)的酯化產(chǎn)物，?GLA?種ω-6脂酸，是??素瘤細(xì)胞增殖抑制劑。γ-LinolenicAcidmethylester能抑制ADP誘導(dǎo)的??板聚集和細(xì)胞凋亡(apoptosis)。體外研究γ-LinolenicAcidmethylester(1-4μg/mL;72h)inducesapoptosisinvitroA-549lungcancercelllinesusingSRBassay.HoweverGLAisduetoitsactionatthegene/oncogenelevelandbyalteringBCl-2expression[1].ApoptosisAnalysis[1]CellLine:A-549lungcancercelllineConcentration:1,2,3,and4μg/mLIncubationTime:72hours;observedat24h,48h,and72hResult:Showedcytotoxicitypotentiallyduetotheinductionofapoptosisoftumorcellsbyaugmentingfreeradicalgenerationonlyinthetumorcellsbutnotnormalcells.體內(nèi)研究γ-LinolenicAcidmethylesterdecreasesthehepatictriglyceridesandhistologicalevidenceoffattyliver1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEinducedbyEtOH[2].γ-LinolenicAcidmethylestercouldsignificantlydecreaselevelsofplasmatotalcholesterol(TC),triglycerides(TG),lowdensitylipoproteincholesterol(LDL-C),MDA,atherosclerosisindex(AI)andliverTC,MDA,andincreaselevelsofhighdensitylipoproteincholesterol(HDL-C)inbothnormalandhyperlipidemicrats[3].AnimalModel:HepaticpatholratsmodelinducedbyEtOH(maleSprague-Dawleyrats,250-300g)[2]Dosage:90mL,50-60mLAdministration:Intraperitonealinjection;oncedaily;administrated90mLduringday1-5andday9,50-60mLduringday6-8Result:Decreasedthehepatictriglyceridesof25.6mg/gcomparedwithsaline(40.2mg/g)oroliveoil(42.8mg/g)treatment.Decreasedliverindex(theratioofliverweightandbodywight)inhyperlipidemicrats,buthadnosignificanteffectinnormalrats.REFERENCES[1].JubieS,etal.IsolationofmethylgammalinolenatefromSpirulinaplatensisusingflashchromatographyanditsapoptosisinducingeffect.BMCComplementAlternMed.2015Aug4;15:263.[2].SegarnickDJ,etal.Gamma-linolenicacidinhibitsthedevelopmentoftheethanol-inducedfattyliver.ProstaglandinsLeukotMed.1985Mar;17(3):277-82.[3].XiuqinK,etal.Studiesonthehypolipidemiceffectsofgamma-linolenicacidmethylesterderivedfromSpirulinamaxima[J].ZhongguohaiYangyaowu=ChineseJournalofMarineDrugs,2003,22(6):30-34.[4].Williams,etal.Antithrombosisagentcontainingγ-linolenicacidorafunctionalderivativeofit:FederalRepublicofGermany,DE2749492[P].1978-05-11.[5].Hiyamuta,etal.Melanomacellproliferationinhibitorscontainingγ-linolenicacidoritsderivatives:Japan,JP2014141427[P].2014-08-07.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedi