NUC-7738-DataSheet-生命科學試劑-MCEVIP

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemENUC-7738Cat.No.:HY-136506CASNo.:2348493-39-8分?式:C??H??N?O?P分?量:568.52作?靶點:Others作?通路:Others儲存?式:Powder-20°C3yearsInsolvent-80°C6months-20°C1month溶解性數據體外實驗DMSO:100mg/mL(175.90mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM1.7590mL8.7948mL17.5895mL5mM0.3518mL1.7590mL3.5179mL10mM0.1759mL0.8795mL1.7590mL請根據產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復凍融造成的產品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲存時，請在6個?內使?，-20°C儲存時，請在1個?內使?。體內實驗請根據您的實驗動物和給藥?式選擇適當的溶解?案。以下溶解?案都請先按照InVitro?式配制澄的儲備液，再依次添加助溶劑：(為保證實驗結果的可靠性，澄的儲備液可以根據儲存條件，適當保存；體內實驗的?作液，建議您現(xiàn)?現(xiàn)配，當天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的?式助溶)1.請依序添加每種溶劑：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.5mg/mL(4.40mM);Clearsolution2.請依序添加每種溶劑：10%DMSO>>90%cornoil1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemESolubility:≥2.5mg/mL(4.40mM);ClearsolutionBIOLOGICALACTIVITY?物活性NUC-77383'-脫氧腺苷的芳氧氨磷酸酯，3'-脫氧腺苷(3'-dA)的5'-芳氧氨磷酸酯前藥。NUC-7738對?組?液癌細胞系具有有效的細胞毒活性。NUC-7738可?于癌癥研究。體外研究NUC-7738(compound7a;0-198μM;72h;CCRF-CEM,HL-60,KG-1,MOLT-4,K562,MV4-11,THP-1,HEL92,NCI-H929,RPMI-8226,Jurkat,Z138,RL,HS445,HepG2,MCF-7,Bx-PC-3,HT29,MIAPaCa-2andSW620cells)hasanticanceractivityandcytotoxicactivityagainstalineageofleukocyteswithLC50valuesof＜30μM[1].NUC-7738(1μM)hasgoodstabilityinhumanhepatocyteswitht1/2valueof48.1min[1].NUC-7738hasincreasedstabilityinhumanplasmacomparedtotheparentnucleoside,withnochangeinplasmaconcentrationupto4h[1].REFERENCES[1].SerpiM,et,al.SynthesisandCharacterizationofNUC-7738,anAryloxyPhosphoramidateof3'-Deoxyadenosine,asaPotentialAnticancerAgent.JMedChem.2022Dec8;65(23):15789-15804.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-82