Norharmane-Standard-生命科學試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemENorharmane(Standard)Cat.No.:HY-W008566RCASNo.:244-63-3分?式:C??H?N?分?量:168.2作?靶點:MonoamineOxidase;EndogenousMetabolite作?通路:NeuronalSignaling;MetabolicEnzyme/Protease儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Norharmane(Standard)Norharmane的分析標準品。本產品?于研究及分析應?。Norharmane(Norharman)?種β-carboline?物堿，?種有效的可逆單胺氧化酶(monoamineoxidase)抑制劑，其對MAO-A和MAO-B的IC50分別為6.5and4.7μM。Norharmane引起抗抑郁反應。Norharmane還?種很有前景的抗癌光敏劑。Norharmane通過抑制PIN2、PIN3和PIN7轉運蛋?來改變極性?長素轉運，從?對擬南芥幼的?長產?顯著的抑制作?。IC50&TargetIC50:4.7μM(MAO-B),6.5μM(MAO-A)[1]REFERENCES[1].HerraizT,etal.Humanmonoamineoxidaseenzymeinhibitionbycoffeeandbeta-carbolinesnorharmanandharmanisolatedfromcoffee.LifeSci.2006Jan18;78(8):795-802.[2].López-GonzálezD,etal.Anaturalindolealkaloid,norharmane,affectsPINexpressionpatternsandcompromisesrootgrowthinArabidopsisthaliana.PlantPhysiolBiochem.2020Jun;151:378-390.[3].Ebrahimi-GhiriM,etal.AnxiolyticandantidepressanteffectsofACPAandharmalineco-treatment.BehavBrainRes.2019May17;364:296-302.[4].SaitoK,ChenCY,MasanaM,CrowleyJS,MarkeySP,HeyesMP.4-Chloro-3-hydroxyanthranilate,6-chlorotryptophanandnorharmaneattenuatequinolinicacidformationbyinterferon-gamma-stimulatedmonocytes(THP-1cells).BiochemJ.1993Apr1;291(Pt1)(Pt1):11-4.[5].PaulBK,etal.BindingofnorharmanewithRNArevealstwothermodynamicallydifferentbindingmodeswithopposingheatcapacitychanges.JColloidInterfaceSci.2019Mar7;538:587-596.[6].LuoHZ,etal.InhibitoryeffectofnorharmaneonSerratiamarcescensNJ01quorumsensing-mediatedvirulencefactorsandbiofilmformation.Biofouling.2021Feb;37(2):145-160.McePdfHeight1/1MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemECaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-