Nirvanol-Ethylphenylhydantoin-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemENirvanolCat.No.:HY-W012481CASNo.:631-07-2Synonyms:Ethylphenylhydantoin;Phenylethyihydantoin;Desmethylmephenytoin分?式:C??H??N?O?分?量:204.23作?靶點(diǎn):DrugMetabolite作?通路:MetabolicEnzyme/Protease儲存?式:4°C,storedundernitrogen*Insolvent:-80°C,6months;-20°C,1month(storedunder

nitrogen)溶解性數(shù)據(jù)體外實(shí)驗DMSO:50mg/mL(244.82mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM4.8964mL24.4822mL48.9644mL5mM0.9793mL4.8964mL9.7929mL10mM0.4896mL2.4482mL4.8964mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month(storedundernitrogen)。-80°C儲存時，請在6個?內(nèi)使?，-20°C儲存時，請在1個?內(nèi)使?。BIOLOGICALACTIVITY?物活性NirvanolMephenytoin的代謝物，在最?電休克(M.E.S.)癲癇??模型中發(fā)揮抗驚厥作?。Nirvanol的ED50為23mg/kg(腹腔注射Nirvanol后30分鐘測量)和30mg/kg(腹腔注射Nirvanol后2?時測量)。Nirvanol有望?于癲癇相關(guān)的神經(jīng)疾病研究[1]。REFERENCES1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE[1].KupferbergHJ,etal.Themetabolismof3-methyl-5-ethyl-5-phenylhydantoin(mephenytoin)to5-ethyl-5-phenylhydantoin(Nirvanol)inmiceinrelationtoanticonvulsantactivity.DrugMetabDispos.1975Jan-Feb;3(1):26-9.PMID:234831.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax:021-53