SDMA-p-hydroxyazobenzene-p-sulfonate-Symmetric-dimethylarginine-p-hydroxyazobenzene-p-sulfonate-生命科學(xué)試劑-MCE-9018

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemESDMA(p-hydroxyazobenzene-p′-sulfonate)Cat.No.:HY-101410ACASNo.:1266235-58-8Synonyms:Symmetricdimethylarginine(p-hydroxyazobenzene-p′-sulfonate);NG,NG'-Dimethyl-L-arginine(p-

hydroxyazobenzene-p′-sulfonate)分?式:C??H??N?O?S.?/?C?H??N?O?分?量:378.41作?靶點(diǎn):EndogenousMetabolite;NOSynthase;NF-κB作?通路:MetabolicEnzyme/Protease;Immunology/Inflammation;NF-κB儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性SDMAp-hydroxyazobenzene-p′-sulfonateSDMA(HY-101410)的對羥偶氮苯-p′-磺酸鹽形式。SDMAp-hydroxyazobenzene-p′-sulfonate內(nèi)性?氧化氮合酶(NOsynthase)的抑制劑。SDMAp-hydroxyazobenzene-p′-sulfonateNF-κB的激活劑，可促進(jìn)IL-6和TNF-α的表達(dá)。SDMAp-hydroxyazobenzene-p′-sulfonate在?和?漿中穩(wěn)定，可?作肝腎功能障礙的?物標(biāo)志物。IC50&TargetHumanEndogenousMetaboliteREFERENCES[1].Bode-B?gerSM,etal.Symmetricaldimethylarginine:anewcombinedparameterforrenalfunctionandextentofcoronaryarterydisease.[2].SchepersE,etal.Symmetricdimethylarginineasaproinflammatoryagentinchronickidneydisease.ClinJAmSocNephrol.2011Oct;6(10):2374-83.[3].NabityMB,etal.SymmetricDimethylarginineAssayValidation,Stability,andEvaluationasaMarkerfortheEarlyDetectionofChronicKidneyDiseaseinDogs.JVetInternMed.2015Jul-Aug;29(4):1036-44.[4].VeldinkH,etal.EffectsofchronicSDMAinfusiononglomerularfiltrationrate,bloodpressure,myocardialfunctionandrenalhistologyinC57BL6/Jmice.NephrolDialTransplant.2013Jun;28(6):1434-9.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-589