Piperacillin-hydrate-Pipracil-hydrate-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEPiperacillinhydrateCat.No.:HY-B1923ACASNo.:66258-76-2Synonyms:Pipracilhydrate分?式:C??H??N?O?S分?量:535.57作?靶點:Antibiotic;Bacterial;Beta-lactamase;Penicillin-bindingprotein(PBP)作?通路:Anti-infection儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Piperacillinhydrate?種半合成的?譜β-內(nèi)酰胺類抗?素，通過霉素結(jié)合蛋?具有對?蘭性和部分?蘭陽性較強的殺活性。Piperacillinhydrate最常與β-內(nèi)酰胺酶抑制劑Tazobactam(HY-B1418)聯(lián)合使?[1][2][3]。體外研究Piperacillin(12.5μg/mL,24h)hydrateinhibits92%ofisolatesofPseudomonasaeruginosa,82%ofSerratiamarcescens,73%ofEscherichiacoli,61%ofKlebsiellaspp,and42%ofEnterobacterspp,mostProteusspp.areextremelysusceptible.Piperacillinhydratefailstoinhibitthegrowthofgram-negativebacilliwhenlargeinoculawereused(minimuminhibitoryconcentration>25μg/mL)[2].體內(nèi)研究Piperacillin(100mg/kg,i.v.,4timesaday,5d)hydrateincombinationwithTazobactam(HY-B1418)(12.5mg/kg,i.v.,4timesaday,5d)prolongssurvivalinmicewithlowinoculumofK.pneumoniae[3].AnimalModel:BALB/clowinoculummodelofK.pneumoniae,KEN-11strain[3].Dosage:100mg/kgAdministration:Intravenousinjection(i.v.),4timesaday,5d,incombinationwithTazobactam(12.5mg/kg,i.v.,4timesaday,5d)Result:Enabledallmicesurvivedwhereasallcontrolmicediedby5d,decreasedthenumberofbacteriainlungscomparedwithcontrolgroup.1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEObservednobacteriainthebloodofmostmice(exceptfortwomiceattheearlyphase)whilebacteriawereobservedinthebloodofcontrolgroup.Observedfewinflammatorycellsinthealveoliwhereasaninfluxofnumerousinflammatorycellswereobservedinthecontrolgroup.戶使?本產(chǎn)品發(fā)表的科研?獻?NatCommun.2022Mar2;13(1):1116.?PLoSPathog.2024Dec31;20(12):e1012783.?AntimicrobAgentsChemother.2023May18;e0160322.?MicrobiolSpectr.2023Apr24;e0069223.?MicrobiolSpectr.2022Dec8;e0303822.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].FuKP,etal.Piperacillin,anewpenicillinactiveagainstmanybacteriaresistanttootherpenicillins.AntimicrobAgentsChemother.1978,13(3):358-67.[2].BodeyGP,etal.Piperacillin:InVitroEvaluation.AntimicrobAgentsChemother.1978,14(1):78-87.[3].HaradaY,etal.Invitroandinvivoactivitiesofpiperacillin-tazobactamandmeropenematdifferentinoculumsizesofESBL-producingKlebsiellapneumoniae.ClinMicrobiolInfect.2014,20(11):O831-9.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplication