Cytarabine-5-monophosphate-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemECytarabine5’-monophosphateCat.No.:HY-W344074CASNo.:7075-11-8分?式:C?H??N?O?P分?量:323.2作?靶點:DNA/RNASynthesis;DrugMetabolite作?通路:CellCycle/DNADamage;MetabolicEnzyme/Protease儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Cytarabine5′-monophosphate核苷類似物Cytarabine(HY-13605)由脫氧胞苷激酶催化產(chǎn)?的代謝物。Cytarabine5′-monophosphate在DNA聚合酶α的作?下被摻?DNA，可降低DNA合成速率。Cytarabine5′-monophosphate在濃度為15mM時抑制釀酵母(S.cerevisiae)中核DNA和線粒體DNA的復(fù)制。此外，Cytarabine5′-monophosphate(3.5-75.1mg/kg)可提???病??(L1210??)的存活率。Cytarabine5′-monophosphate可?于癌癥領(lǐng)域研究[1]。REFERENCES[1].MomparlerRL,etal.Mammaliandeoxynucleosidekinase.I.Deoxycytidinekinase:purification,properties,andkineticstudieswithcytosinearabinoside.JBiolChem.1968Aug25;243(16):4298-304.[2].HuangS,etal.Developmentandapplicationofarapidandsensitiveliquidchromatography-massspectrometrymethodforsimultaneousanalysisofcytarabine,cytarabinemonophosphate,cytarabinediphosphateandcytarabinetriphosphateinthecytosolandnucleus.JPharmBiomedAnal.2022Mar20;211:114582.[3].PerrinoFW,etal.IncorporationofcytosinearabinosidemonophosphateintoDNAatinternucleotidelinkagesbyhumanDNApolymerasealpha.JBiolChem.1992Nov15;267(32):23043-51.[4].McIntoshEM,etal.InhibitionofDNAreplicationinSaccharomycescerevisiaebyaraCMP.CurrGenet.1986;10(8):579-85.[5].SchreckerAW,etal.Antitumoreffectandmodeofactionof1-beta-D-arabinofuranosylcytosine5'-phosphateinleukemiaL1210.CancerRes.1968Apr;28(4):802-3.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;0