Oseltamivir-13C-d3-phosphate-GS-4104-sup-13-sup-C-d-sub-3-sub-phosphate-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEOseltamivir-13C,d3phosphateCat.No.:HY-17016S3CASNo.:2734920-81-9Synonyms:GS4104-13C,d3phosphate分?式:C????CH??D?N?O?P分?量:414.41作?靶點(diǎn):Isotope-LabeledCompounds;InfluenzaVirus作?通路:Others;Anti-infection儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性O(shè)seltamivir-13C,d3(phosphate)(GS4104-13C,d3(phosphate))13C標(biāo)記的Oseltamivir(phosphate).Oseltamivirphosphate(GS4104)?種神經(jīng)氨酸酶(neuraminidase)抑制劑，?于流感(influenzaA和B)的研究。體外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattentionbecauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.REFERENCES[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-216.[2].HuangH,etal.TransplacentaltransferofOseltamivirphosphateanditsmetaboliteOseltamivircarboxylateusingtheexvivohumanplacentaperfusionmodelinChineseHanspopulation.JMaternFetalNeonatalMed.2016Aug8:1-5.[3].deOliveiraJT,etal.Anti-influenzaneuraminidaseinhibitorOseltamivirphosphateinducescaninemammarycancercellaggressiveness.PLoSOne.2015Apr7;10(4):e0121590.[4].LiP,etal.ASimpleandRobustApproachforEvaluationofAntiviralsUsingaRecombinantInfluenzaVirusExpressingGaussiaLuciferase.Viruses.2018Jun13;10(6).pii:E325.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-5