D-α-Hydroxyglutaric-acid-disodium-Standard-Disodium-R-2-hydroxyglutarate-Standard-生命科學試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemED-α-Hydroxyglutaricaciddisodium(Standard)Cat.No.:HY-100542RCASNo.:103404-90-6Synonyms:Disodium(R)-2-hydroxyglutarate(Standard)分?式:C?H?Na?O?分?量:192.08作?靶點:ReactiveOxygenSpecies;ATPSynthase;mTOR;EndogenousMetabolite作?通路:Immunology/Inflammation;MetabolicEnzyme/Protease;NF-κB;MembraneTransporter/IonChannel;PI3K/Akt/mTOR儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性D-α-Hydroxyglutaricacid(disodium)(Standard)D-α-Hydroxyglutaricacid(disodium)的分析標準品。本產品?于研究及分析應?。D-α-Hydroxyglutaricaciddisodium(Disodium(R)-2-hydroxyglutarate)神經代謝疾病D-2-羥戊?酸尿癥中積累的主代謝產物。D-α-Hydroxyglutaricaciddisodiumα-酮戊?酸(α-KG)的弱競爭拮抗劑，可抑制多種α-KG依賴性雙加氧酶(dioxygenases)，Ki為10.87mM。D-α-Hydroxyglutaricaciddisodium可增加活性氧(ROS)的產?。D-α-Hydroxyglutaricaciddisodium還可結合并抑制ATP合酶并抑制mTOR信號傳導。IC50&TargetKi:10.87mM(α-KG-dependentdioxygenases)[1]ATPsynthase[2]mTOR[2]Reactiveoxygenspecies(ROS)[5]REFERENCES[1].XuW,etal.Oncometabolite2-hydroxyglutarateisacompetitiveinhibitorofα-ketoglutarate-dependentdioxygenases.CancerCell.2011Jan18;19(1):17-30.[2].FuX,etal.2-HydroxyglutarateInhibitsATPSynthaseandmTORSignaling.CellMetab.2015Sep1;22(3):508-15.[3].MartijnKranendijk,etal.Progressinunderstanding2-hydroxyglutaricacidurias.JInheritMetabDis.2012Jul;35(4):571-87.[4].MartinB?ttcher,etal.D-2-hydroxyglutarateinterfereswithHIF-1αstabilityskewingT-cellmetabolismtowardsoxidativephosphorylationandimpairingTh17polarization.Oncoimmunology.2018Mar26;7(7):e1445454.1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE[5].AlexandraLatini,etal.D-2-hydroxyglutaricacidinducesoxidativestressincerebralcortexofyoungrats.EurJNeurosci.2003May;17(10):2017-22.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-8