當(dāng)今干細(xì)胞研究方面的10位頂尖科學(xué)家

1、排名第一：Shinya Yamanaka和JamesA.Thomson博士是建立了可誘導(dǎo)的萬能干細(xì)胞，在干細(xì)胞再生和分化重排機(jī)理上做出了最具突破性的進(jìn)展性工作；這毫無疑問是諾貝爾獎(jiǎng)級(jí)的工作，其他幾位平時(shí)工作很杰出，可是沒有這種級(jí)別的工作，只好屈居次位；排名第二：Rudolf Jaenisch博士長(zhǎng)期從事于干細(xì)胞核的替代重組和干細(xì)胞的表觀遺傳修飾工作，卓有成績(jī)，這也是培養(yǎng)誘導(dǎo)干細(xì)胞的核心工作，重要性無人能代替；排名第三： Rebort lanza博士領(lǐng)導(dǎo)和指揮著全球最領(lǐng)先的干細(xì)胞生物技術(shù)公司，獨(dú)創(chuàng)和建立了分離和培養(yǎng)單個(gè)胚胎干細(xì)胞的方法和技術(shù)。主編了所有重要的干細(xì)胞參考書籍。每一相重大干細(xì)胞技術(shù)的

2、出現(xiàn)，美歐主流媒體都要聽他的意見，可謂干細(xì)胞領(lǐng)域的大腕人物；排名第四：Alan Trounson博士是國(guó)際免疫學(xué)和干細(xì)胞研究的先驅(qū)者，領(lǐng)導(dǎo)和指揮原澳大利亞Monash大學(xué)免疫學(xué)和干細(xì)胞研究實(shí)驗(yàn)室，使Monash大學(xué)成為世界上最成功的大學(xué)之一。手下的弟子Martin Perl博士出任南加州大學(xué)第一界干細(xì)胞和系統(tǒng)生物學(xué)所所長(zhǎng)。2007年成為美國(guó)眼下資金最多，實(shí)力最強(qiáng)的加州再生醫(yī)學(xué)研究研究所所長(zhǎng)，成為美國(guó)干細(xì)胞研究中最大的老板；排名第五：哈佛大學(xué)干細(xì)胞研究所所長(zhǎng)Douglas A. Melton博士和斯坦福大學(xué)干細(xì)胞和再生醫(yī)學(xué)研究所所長(zhǎng)Irving L. Weissman博士?jī)扇硕际歉杉?xì)胞研究領(lǐng)域的

3、頂尖高手，又各了帶領(lǐng)著東西兩岸這兩所美國(guó)奈至全世界的頂尖學(xué)府的干細(xì)胞研究的竟賽。排名第六：哈佛大學(xué)干細(xì)胞研究所共同所長(zhǎng)David T. Scadden, 博士和密西根大學(xué)干細(xì)胞中心主Sean Morrison博士?jī)扇耸歉杉?xì)胞研究的中青年骨干，專長(zhǎng)于干細(xì)胞分化再生的微環(huán)境調(diào)控機(jī)理的研究，. Scadden, 博士是麻省總醫(yī)院再生醫(yī)學(xué)研究所所長(zhǎng)，側(cè)重于干細(xì)胞的臨床應(yīng)用。Morrison博士則是休斯醫(yī)學(xué)研究所研究員，是美國(guó)中西部大學(xué)中干細(xì)胞研究的頂級(jí)人物。排名第七到第十的是國(guó)際上知名的干細(xì)胞專家，包括愛丁堡大學(xué)克隆了多利羊的Wilmut教授，皮膚毛發(fā)干細(xì)胞再生醫(yī)學(xué)領(lǐng)軍人物Fuchs教授和把干細(xì)胞用于

4、臨床治療的先鋒人物瑞典的Lindvall教授，以及華人中干細(xì)胞研究的頂尖人物，由中國(guó)人出任的耶魯大學(xué)干細(xì)胞中心主任林海帆教授。第一位：Shinya Yamanaka，Ph.D. 日本京都大學(xué)前沿醫(yī)學(xué)研究所干細(xì)胞生物學(xué)系，加州大學(xué)舊金山分校心血管疾病研究所教授代表作文章1. Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, Yamanaka S.Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Ce

5、ll. 2007 Nov 30;131(5):861-72. 2. Okita K, Ichisaka T, Yamanaka S. Generation of germline-competent induced pluripotent stem cells.Nature. 2007 Jul 19;448(7151):313-7. 3. Nakagawa M, Koyanagi M, Tanabe K, Takahashi K, Ichisaka T, Aoi T, Okita K, Mochiduki Y, Takizawa N, Yamanaka S. Generation of ind

6、uced pluripotent stem cells without Myc from mouse and human fibroblasts.Nat Biotechnol. 2007 Nov 30;4. Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006 Aug 25;126(4):663-76. Epub 2006 Aug 10。5. Takahashi K

7、, Ichisaka T, Yamanaka S. Identification of genes involved in tumor-like properties of embryonic stem cells. Methods Mol Biol. 2006;329:449-58. 并列第一位：JamesA.Thomson Ph.D.威斯康星大學(xué)基因組研究中心主任，解剖學(xué)系教授代表作文章1.Yu J, Vodyanik MA, Smuga-Otto K, Antosiewicz-Bourget J, Frane JL, Tian S, Nie J, Jonsdottir GA, Ruott

8、i V, Stewart R, Slukvin II, Thomson JA.Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells。Science. 2007 Nov 202.Ludwig TE, Bergendahl V, Levenstein ME, Yu J, Probasco MD, Thomson JA.Feeder-independent culture of human embryonic stem cells.Nat Methods. 2006 Aug;3(8):637-463.Ludwig T

9、E, Levenstein ME, Jones JM, Berggren WT, Mitchen ER, Frane JL, Crandall LJ, Daigh CA, Conard KR, Piekarczyk MS, Llanas RA, Thomson JA.Derivation of human embryonic stem cells in defined conditions.Nat Biotechnol. 2006 Feb;24(2):185-7.4. Yu J, Vodyanik MA, He P, Slukvin II, Thomson JA.Human embryonic

10、 stem cells reprogram myeloid precursors following cell-cell fusion.Stem Cells. 2006 Jan;24(1):168-76. Epub 2005 Oct 65. Sperger JM, Chen X, Draper JS, Antosiewicz JE, Chon CH, Jones SB, Brooks JD, Andrews PW, Brown PO , Thomson JA.Gene expression patterns in human embryonic stem cells and human plu

11、ripotent germ cell tumors.Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13350-5.第二位：Rudolf Jaenisch MD，麻省理工學(xué)院白頭生物研究所教授代表作文章1. Hanna J, Wernig M, Markoulaki S, Sun CW, Meissner A, Cassady JP, Beard C, Brambrink T, Wu LC, Townes TM, Jaenisch R.Treatment of Sickle Cell Anemia Mouse Model with iPS Cells

12、 Generated from Autologous Skin.Science. 2007 Dec 6；2. Meissner A, Wernig M, Jaenisch R.Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cells.Nat Biotechnol. 2007 Oct;25(10):1177-81；3. Wernig M, Meissner A, Foreman R, Brambrink T, Ku M, Hochedlinger K, Bernstein BE,

13、Jaenisch R.In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state.Nature. 2007 Jul 19;448(7151):318-24；4. Boyer LA, Plath K, Zeitlinger J, Brambrink T, Medeiros LA, Lee TI, Levine SS, Wernig M, Tajonar A, Ray MK, Bell GW, Otte AP, Vidal M, Gifford DK, Young RA, Jaenisch R.Polyco

14、mb complexes repress developmental regulators in murine embryonic stem cells.Nature. 2006 May 18;441(7091):349-53；5. Meissner A, Jaenisch R.Generation of nuclear transfer-derived pluripotent ES cells from cloned Cdx2-deficient blastocysts.Nature. 2006 Jan 12;439(7073):212-5。第三位： Rebort lanza Ph.D. 麻

15、省先進(jìn)細(xì)胞公司首席科學(xué)家，北卡州Wake Forest 大學(xué)醫(yī)學(xué)院教授1. Klimanskaya I, Chung Y, Becker S, Lu SJ, Lanza R.Human embryonic stem cell lines derived from single blastomeres.Nature. 2006 Nov 23;444(7118):481-5. 2. Lu SJ, Feng Q, Caballero S, Chen Y, Moore MA, Grant MB, Lanza R.Generation of functional hemangioblasts from

16、human embryonic stem cells.Nat Methods. 2007 Jun;4(6):501-93. Chung Y, Klimanskaya I, Becker S, Marh J, Lu SJ, Johnson J, Meisner L, Lanza R.Embryonic and extraembryonic stem cell lines derived from single mouse blastomeres.Nature. 2006 Jan 12;439(7073):216-9.4. Lanza RP, Chung HY, Yoo JJ, Wettstein

17、 PJ, Blackwell C, Borson N, Hofmeister E, Schuch G, Soker S, Moraes CT, West MD, Atala A. Generation of histocompatible tissues using nuclear transplantation. Nat Biotechnol. 2002 Jul;20(7):689-96.5. Lanza RP, Cibelli JB, Blackwell C, Cristofalo VJ, Francis MK, Baerlocher GM, Mak J, Schertzer M, Cha

18、vez EA, Sawyer N, Lansdorp PM, West MD. Extension of cell life-span and telomere length in animals cloned from senescent somatic cells. Science. 2000 Apr28;288(5466):665-9第四位：Alan Trounson Ph.D. 加州再生醫(yī)學(xué)研究研究所所長(zhǎng)，教授（原澳大利亞Monash大學(xué)免疫學(xué)和干細(xì)胞研究實(shí)驗(yàn)室主任）代表作文章1. GQ Daley, L AhrlundRichter,JM Auerbach, N Benvenisty

19、, RA Charo, G Chen, HK Deng,LS Goldstein, KL Hudson, I Hyun, SC Junn, J Love, EH Lee, A McLaren, CL Mummery,N Nakatsuji, C Racowsky, H Rooke, J Rossant, HR Scholer, JH Solbakk, P Taylor, AOTrounson, IL Weissman, I Wilmut, J Yu, L Zoloth (2007) The ISSCR Guidelines for Human Embryonic Stem Cell Resea

20、rch. Science 315: 603604. 303. 2. A Giudice and A Trounson (2007) Genetic manipulation of human embryonic stem cells for cell based therapy. Nature Biotech；3. M Snow, SL Cox, G Jenkin, A Trounson, J Shaw (2002) Generation of live young from xenografted mouse ovaries. Science 297: 2227.4. BE Reubinof

21、f, MF Pera, CY Fong, A Trounson, A Bongso (2000) Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro. Nature Biotechn. 18: 399404.5. AT Dowsing, EL Yong, M Clark, RI McLachlan, DM de Kretser, AO Trounson (1999) Linkage between male infertility and trinucleotide repeat

22、expansion in the androgen receptor gene. Lancet 354: 640643.第五位：Douglas A. Melton, Ph.D，哈佛大學(xué)干細(xì)胞研究所所長(zhǎng)，Howard Hughes Medical Institute研究員。代表作文章1. Stanger BZ, Tanaka AJ, Melton DA.Organ size is limited by the number of embryonic progenitor cells in the pancreas but not the liver.Nature. 2007 Feb 22;445

23、(7130):886-91.2. Cowan CA, Atienza J, Melton DA, Eggan K.Nuclear reprogramming of somatic cells after fusion with human embryonic stem cells.Science. 2005 Aug 26;309(5739):1369-73. 3. Dor Y, Brown J, Martinez OI, Melton DA.Adult pancreatic beta-cells are formed by self-duplication rather than stem-c

24、ell differentiation.Nature. 2004 May 6;429(6987):41-6. 4. Rajagopal J, Anderson WJ, Kume S, Martinez OI, Melton DA.Insulin staining of ES cell progeny from insulin uptake.Science. 2003 Jan 17;299(5605):363.5. Ramalho-Santos M, Yoon S, Matsuzaki Y, Mulligan RC, Melton DA."Stemness": transcr

25、iptional profiling of embryonic and adult stem cells.Science. 2002 Oct 18;298(5593):597-600.并列第5位Irving L. Weissman MD. 斯坦福大學(xué)干細(xì)胞和再生醫(yī)學(xué)研究所所長(zhǎng)代表作文章1.Rossi DJ, Bryder D, Seita J, Nussenzweig A, Hoeijmakers J, Weissman IL "Deficiencies in DNA damage repair limit the function of haematopoietic stem ce

26、lls with age." Nature 2007; 447: 7145: 725-92. Forsberg EC, Serwold T, Kogan S, Weissman IL, Passegué E.New evidence supporting megakaryocyte-erythrocyte potential of flk2/flt3+ multipotent hematopoietic progenitors.Cell. 2006 Jul 28;126(2):415-263. Laird DJ, De Tomaso AW, Weissman IL.Stem

27、 cells are units of natural selection in a colonial ascidian.Cell. 2005 Dec 29;123(7):1351-604. De Tomaso AW, Nyholm SV, Palmeri KJ, Ishizuka KJ, Ludington WB, Mitchel K, Weissman IL.Isolation and characterization of a protochordate histocompatibility locus.Nature. 2005 Nov 24;438(7067):454-95. Pass

28、egué E, Wagner EF, Weissman IL.JunB deficiency leads to a myeloproliferative disorder arising from hematopoietic stem cells.Cell. 2004 Oct 29;119(3):431-43. 第六位：David T. Scadden, M.D.Director, Center for Regenerative Medicine, Massachusetts General Hospital，Co-Director, Harvard Stem Cell Instit

29、ute, Harvard University。麻省總醫(yī)院再生醫(yī)學(xué)研究所所長(zhǎng)，哈佛大學(xué)干細(xì)胞研究所共同所長(zhǎng)代表作文章1. Janzen V, Forkert R, Fleming HE, Saito Y, Waring MT, Dombkowski DM, Cheng T, DePinho RA, Sharpless NE, Scadden DT.Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a.Nature. 2006 Sep 28;443(7110):421-6.2. Scadden DT

30、.The stem-cell niche as an entity of action.Nature. 2006 Jun 29;441(7097):1075-9；3. Adams GB, Chabner KT, Alley IR, Olson DP, Szczepiorkowski ZM, Poznansky MC, Kos CH, Pollak MR, Brown EM, Scadden DT.Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor.Nature. 20

31、06 Feb 2;439(7076):599-603；4. Johnson J, Bagley J, Skaznik-Wikiel M, Lee HJ, Adams GB, Niikura Y, Tschudy KS, Tilly JC, Cortes ML, Forkert R, Spitzer T, Iacomini J, Scadden DT, Tilly JL.Oocyte generation in adult mammalian ovaries by putative germ cells in bone marrow and peripheral blood.Cell. 2005

32、 Jul 29;122(2):303-155. Calvi LM, Adams GB, Weibrecht KW, Weber JM, Olson DP, Knight MC, Martin RP, Schipani E, Divieti P, Bringhurst FR, Milner LA, Kronenberg HM, Scadden DT.Osteoblastic cells regulate the haematopoietic stem cell niche.Nature. 2003 Oct 23;425(6960):841-6。并列第六位Sean Morrison, PhD密西根

33、大學(xué)干細(xì)胞中心主任Director,Center for Stem Cell Biology, University of Michigan，Howard Hughes Medical Institute, USA代表作文章1. Morrison SJ, Spradling AC. Stem cells and niches: mechanisms that promote stem cell maintenance throughout life. Cell. 2008 Feb 22;132(4):598-6112. Kiel MJ, He S, Ashkenazi R, Gentry SN

34、, Teta M, Kushner JA, Jackson TL, Morrison SJ. Haematopoietic stem cells do not asymmetrically segregate chromosomes or retain BrdU.Nature. 2007 Sep 13;449(7159):238-42.3. Kim I, Saunders TL, Morrison SJ.Sox17 dependence distinguishes the transcriptional regulation of fetal from adult hematopoietic

35、stem cells. Cell. 2007 Aug 10;130(3):470-83.4. Molofsky AV, Slutsky SG, Joseph NM, He S, Pardal R, Krishnamurthy J, Sharpless NE, Morrison SJ.Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing. Nature. 2006 Sep 28;443(7110):448-52.5. Yilmaz OH, Valdez R, Th

36、eisen BK, Guo W, Ferguson DO, Wu H, Morrison SJ.Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells.Nature. 2006 May 25;441(7092):475-82.第七位George Daley, M.D., Ph.D哈佛大學(xué)干細(xì)胞研究所，波士頓兒童醫(yī)院教授代表作文章1. Park IH, Zhao R, West JA, Yabuuchi A, Huo H, Ince TA, Lerou PH, Lensch M

37、W, Daley GQ.Reprogramming of human somatic cells to pluripotency with defined factors.Nature. 2008 Jan 10;451(7175):141-6.2. North TE, Goessling W, Walkley CR, Lengerke C, Kopani KR, Lord AM, Weber GJ, Bowman TV, Jang IH, Grosser T, Fitzgerald GA , Daley GQ, Orkin SH, Zon LI.Prostaglandin E2 regulat

38、es vertebrate haematopoietic stem cell homeostasis.Nature. 2007 Jun 21;447(7147):1007-113. Daley GQ, Ahrlund Richter L, Auerbach JM, Benvenisty N, Charo RA, Chen G, Deng HK, Goldstein LS, Hudson KL, Hyun I, Junn SC, Love J, Lee EH, McLaren A, Mummery CL, Nakatsuji N, Racowsky C, Rooke H, Rossant J,

39、Schöler HR, Solbakk JH, Taylor P, Trounson AO, Weissman IL, Wilmut I, Yu J, Zoloth L.Ethics. The ISSCR guidelines for human embryonic stem cell research.Science. 2007 Feb 2;315(5812):603-4；4. Kim K, Lerou P, Yabuuchi A, Lengerke C, Ng K, West J, Kirby A, Daly MJ, Daley GQ.Histocompatible em

40、bryonic stem cells by parthenogenesis.Science. 2007 Jan 26;315(5811):482-6；5Geijsen N, Horoschak M, Kim K, Gribnau J, Eggan K, Daley GQ.Derivation of embryonic germ cells and male gametes from embryonic stem cells.Nature. 2004 Jan 8;427(6970):148-54.并列第七位Fred H. Gage, PhD，Salk Institute for Biologic

41、al Studies， California, USA 美國(guó)加州索克生物研究所教授代表作文章1.Zhao C, Deng W, Gage FH.Mechanisms and functional implications of adult neurogenesis. Cell. 2008 Feb 22;132(4):645-60；2. Zhang CL, Zou Y, He W, Gage FH, Evans RM. A role for adult TLX-positive neural stem cells in learning and behaviour.Nature. 2008 Fe

42、b 21;451(7181):1004-7.3. Tashiro A, Sandler VM, Toni N, Zhao C, Gage FH.NMDA-receptor-mediated, cell-specific integration of new neurons in adult dentate gyrus.Nature. 2006 Aug 24;442(7105):929-33.4. Muotri AR, Gage FH.Generation of neuronal variability and complexity.Nature. 2006 Jun 29;441(7097):1

43、087-93.5. Lie DC, Colamarino SA, Song HJ, Désiré L, Mira H, Consiglio A, Lein ES, Jessberger S, Lansford H, Dearie AR, Gage FH.Wnt signalling regulates adult hippocampal neurogenesis. Nature. 2005 Oct 27;437(7063):1370-5第八位Alan Colman， Ph.D. director of stem-cell research at Kings College

44、London， UK代表作文章1. Colman A.Everyone listed on Dolly paper met established criteria for authorship.Nature. 2006 Apr 27;440(7088):1112；2. Buzzard JJ, Gough NM , Crook JM, Colman A.Karyotype of human ES cells during extended culture.Nat Biotechnol. 2004 Apr;22(4):381-2;3. Polejaeva IA, Chen SH, Vaught

45、TD, Page RL, Mullins J, Ball S, Dai Y, Boone J, Walker S, Ayares DL, Colman A, Campbell KH.Cloned pigs produced by nuclear transfer from adult somatic cells.Nature. 2000 Sep 7;407(6800):86-90. 4. Gurdon JB, Colman A.The future of cloning.Nature. 1999 Dec 16;402(6763):743-6.5. Colman A, Kind A.Therap

46、eutic cloning: concepts and practicalities.Trends Biotechnol. 2000 May;18(5):192-6并列第8位Fiona Watt, DPhil，ancer Research UK, Cambridge Research Institute， UK1.Watt FM, Frye M, Benitah SA.MYC in mammalian epidermis: how can an oncogene stimulate differentiation?Nat Rev Cancer. 2008 Mar;8(3):234-42. 2.

47、 Takeda H, Lyle S, Lazar AJ, Zouboulis CC, Smyth I, Watt FM.Human sebaceous tumors harbor inactivating mutations in LEF1.Nat Med. 2006 Apr;12(4):395-7.3. Benitah SA, Frye M, Glogauer M, Watt FM.Stem cell depletion through epidermal deletion of Rac1.Science. 2005 Aug 5;309(5736):933-5. 4. Watt FM, Ho

48、gan BL.Out of Eden: stem cells and their niches.Science. 2000 Feb 25;287(5457):1427-30.5. Gandarillas A, Watt FM.c-Myc promotes differentiation of human epidermal stem cells.Genes Dev. 1997 Nov 1;11(21):2869-82. 第9位Ian Wilmut, PhD, DSc，英國(guó)愛丁堡大學(xué)再生醫(yī)學(xué)中心教授，University of Edinburgh , Scottish Centre for Re

49、generative Medicine， UK 1. Wilmut I, Taylor J.Stem cells: primates join the club.Nature. 2007 Nov 22;450(7169):485-6.2. ilmut I, West MD, Lanza RP, Gearhart JD, Smith A, Colman A, Trounson AO, Campbell KH.Human embryonic stem cells.Science. 2005 Dec 23;310(5756):1903. Epub 2005 Dec 13.3. Wilmut I, B

50、eaujean N, de Sousa PA, Dinnyes A, King TJ, Paterson LA, Wells DN, Young LE.Somatic cell nuclear transfer.Nature. 2002 Oct 10;419(6907):583-6. 4. Ashworth D, Bishop M, Campbell K, Colman A, Kind A, Schnieke A, Blott S, Griffin H, Haley C, McWhir J, Wilmut I.DNA microsatellite analysis of Dolly.Natur

51、e. 1998 Jul 23;394(6691):329。5. Campbell KH, McWhir J, Ritchie WA, Wilmut I.Sheep cloned by nuclear transfer from a cultured cell line.Nature. 1996 Mar 7;380(6569):64-6. 并列第9位Elaine Fuchs, PhDRockefeller University，Howard Hughes Medical Institute， USA美國(guó)洛克菲勒大學(xué)教授，休斯醫(yī)學(xué)研究所研究員。代表作文章1.Yi R, Poy MN , Stoff

52、el M, Fuchs E.A skin microRNA promotes differentiation by repressing 'stemness'.Nature.452(7184):225-9。2008 Mar 13;2. Horsley V, Aliprantis AO, Polak L, Glimcher LH, Fuchs E.NFATc1 balances quiescence and proliferation of skin stem cells.Cell. 2008 Jan 25;132(2):299-310. 3. Nguyen H, Rendl M

53、, Fuchs E.Tcf3 governs stem cell features and represses cell fate determination in skin.Cell. 2006 Oct 6;127(1):171-83. 4. Horsley V, O'Carroll D, Tooze R, Ohinata Y, Saitou M, Obukhanych T, Nussenzweig M, Tarakhovsky A, Fuchs E.Blimp1 defines a progenitor population that governs cellular input to the sebaceous gland.Cell. 2006 Aug 11;126(3):597-6095. Perez-M