ANCA相關(guān)性血管炎腎損害病理表現(xiàn)PPT學(xué)習(xí)教案

1、會計(jì)學(xué)1ANCA相關(guān)性血管炎腎損害病理表現(xiàn)相關(guān)性血管炎腎損害病理表現(xiàn)P-ANCA Perinuclear PatternAnti-myeloperoxidaseMPO-ANCAC-ANCA Cytoplasmic PatternAnti-Proteinase 3PR3-ANCAAnti-Neutrophil Cytoplasmic Autoantibodies (ANCA)第1頁/共17頁Large Vessel VasculitisGiant Cell ArteritisTakayasu ArteritisMedium Vessel VasculitisPolyarteritis Nodos

2、aKawasaki DiseaseSmall Vessel VasculitisANCA-Associated Vasculitis（AASV）Microscopic PolyangiitisGranulomatosis with Polyangiitis (Wegeners)Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss)Immune Complex VasculitisAnti-GBM DiseaseIgA Vasculitis (Henoch-Schnlein)Cryoglobulinemic Vasculitis

3、Hypocomplementemic Urticarial Vasculitis (Anti-C1q Vasculitis)Variable Vessel Vasculitis (Cogans, Behcets, etc.)Single Organ Vasculitis (cutaneous SVV, primary CNS vasculitis, etc.)Vasculitis Associated with Systemic Diseases (e.g. Rheumatoid, Lupus, Sarcoid, etc.)Vasculitis Associated with Probable

4、 Etiologies (e.g. HBV, HCV, drug, cancer, etc.) 2011 Chapel Hill Consensus Conference Vasculitis Nomenclature第2頁/共17頁ANCA相關(guān)小血管炎腎損害病理表現(xiàn)第3頁/共17頁第4頁/共17頁細(xì)胞性新月體細(xì)胞性新月體纖維細(xì)胞性新月體纖維細(xì)胞性新月體第5頁/共17頁小葉間動脈纖維素樣壞死小葉間動脈纖維素樣壞死腎間質(zhì)大量炎癥細(xì)胞浸潤腎間質(zhì)大量炎癥細(xì)胞浸潤第6頁/共17頁小葉間動脈纖維素樣壞死，內(nèi)膜水腫伴炎癥細(xì)胞浸潤腎間質(zhì)大量炎癥細(xì)胞浸潤小葉間動脈纖維素樣壞死，內(nèi)膜水腫伴炎癥細(xì)胞浸潤腎間質(zhì)大量炎癥細(xì)胞浸潤第7頁/共17頁慢性化表現(xiàn)：小葉間動脈管腔內(nèi)水腫，炎癥細(xì)胞浸潤慢性化表現(xiàn)：小葉間動脈管腔內(nèi)水腫，炎癥細(xì)胞浸潤 血管腔內(nèi)膜和肌層均纖維化血管腔內(nèi)膜和肌層均纖維化第8頁/共17頁第9頁/共17頁第10頁/共17頁第11頁/共17頁第12頁/共17頁IgG400第13頁/共17頁左：纖維素樣壞死左：纖維素樣壞死右：從一個(gè)纖維素樣壞死病灶蔓延至相鄰小新月體右：從一個(gè)纖維素樣壞死病灶蔓延至相鄰小新月體Fibrin400第14頁/共17頁毛細(xì)血管袢基底膜斷裂毛細(xì)血管袢基底膜斷裂第15頁