Aminoacyl-tRNA-Synthetase-Inhibitors-Modulators-MCE

1、 HYPERLINK https:/www.MedChemE/Targets/Aminoacyl-tRNA Synthetase.html Aminoacyl-tRNA HYPERLINK https:/www.MedChemE/Targets/Aminoacyl-tRNA Synthetase.html HYPERLINK https:/www.MedChemE/Targets/Aminoacyl-tRNA Synthetase.html SynthetasetRNA Synthetase, aaRSAminoacyl-tRNA synthetases (AARSs) are the enz

2、ymes that catalyze the aminoacylation reaction by covalently linking an amino acidto its cognate tRNA in the first step of protein translation. In mammals, AARSs usually exist in free form or in the form of amulti-tRNA synthetase complex (MSC), and the latter consists of eight AARSs and three non-en

3、zymatic AARS-interactingmulti-functional proteins (AIMP1/p43, AIMP2/p38, and AIMP3/p18).AARSs are responsible for the proper pairing of codons on mRNA with amino acids. AARSs are also involved in RNA splicing,transcriptional regulation, translation, and other aspects of cellular homeostasis. Study o

4、f these enzymes is of great interest to theresearchers due to its pivotal role in the growth and survival of an organism. AARSs are one of the leading targets for developingnovel anti-infective agents. Further, unfolding the interesting structural and functional aspects of these enzymes in the last

5、fewyears has qualified them as a potential drug target against various diseases.www.MedChemE 1 HYPERLINK https:/www.MedChemE/Targets/Aminoacyl-tRNA Synthetase.html Aminoacyl-tRNA HYPERLINK https:/www.MedChemE/Targets/Aminoacyl-tRNA Synthetase.html HYPERLINK https:/www.MedChemE/Targets/Aminoacyl-tRNA

6、 Synthetase.html Synthetase HYPERLINK https:/www.MedChemE/Targets/Aminoacyl-tRNA Synthetase.html HYPERLINK https:/www.MedChemE/Targets/Aminoacyl-tRNA Synthetase.html Inhibitors HYPERLINK https:/www.MedChemE/Aminoacyl_tRNA_synthetase-IN-1.html Aminoacyl HYPERLINK https:/www.MedChemE/Aminoacyl_tRNA_sy

7、nthetase-IN-1.html HYPERLINK https:/www.MedChemE/Aminoacyl_tRNA_synthetase-IN-1.html tRNA HYPERLINK https:/www.MedChemE/Aminoacyl_tRNA_synthetase-IN-1.html HYPERLINK https:/www.MedChemE/Aminoacyl_tRNA_synthetase-IN-1.html synthetase-IN-1 HYPERLINK https:/www.MedChemE/Aminoacyl_tRNA_synthetase-IN-1.h

8、tml HYPERLINK https:/www.MedChemE/Arg-AMS.html Arg-AMSCat. No.: HY-108939 Cat. No.: HY-112862Aminoacyl tRNA synthetase-IN-1 is a bacterialaminoacyl tRNA synthetase (aaRS) inhibitor.Arg-AMS is a potent nanomolar inhibitor of arginyltRNA synthetase, which displays tightly boundinhibitory characteristi

9、cs for the A-domains innon-ribosomal peptide synthetases (NRPS) enzymes.Purity: 99.63%Clinical Data: No Development ReportedSize: 1 mg, 5 mg, 10 mgPurity: 98.0%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 25 mg HYPERLINK https:/www.MedChemE/Asp-AMS.html Asp-AMS HYPERLINK https:/www.MedCh

10、emE/Asp-AMS.html HYPERLINK https:/www.MedChemE/bc-li-0186.html BC-LI-0186Cat. No.: HY-112860 Cat. No.: HY-136265Asp-AMS, an analogue of aspartyl-adenylate, is anaspartyl-tRNA synthetase inhibitor and also astrong competitive inhibitor of themitochondrial enzyme.BC-LI-0186 is a potent and selective i

11、nhibitor ofLeucyl-tRNA synthetase (LRS; LeuRS) andRas-related GTP-binding protein D (RagD)interaction (IC =46.11 nM).50Purity: 98%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 25 mgPurity: 98.85%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 25 mg, 50 mg, 100 mg HYPERLINK https:

12、/www.MedChemE/Gln-AMS.html Gln-AMS HYPERLINK https:/www.MedChemE/Gln-AMS.html HYPERLINK https:/www.MedChemE/Gln-AMS_TFA.html Gln-AMS HYPERLINK https:/www.MedChemE/Gln-AMS_TFA.html HYPERLINK https:/www.MedChemE/Gln-AMS_TFA.html TFACat. No.: HY-112861 Cat. No.: HY-112861AGln-AMS is an aminoacyl-tRNA s

13、ynthetases (AARS)inhibitor, which binds the A-domain within theNRPS enzymes.Gln-AMS (TFA) is a type Ia aminoacyl-tRNAsynthetase (AARS) inhibitor. Gln-AMS inhibitsglutaminyl-tRNA synthetase (GlnRS) with a K ofi1.32 M.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98.73%Clini

14、cal Data: No Development ReportedSize: 5 mg, 10 mg, 25 mg, 50 mg, 100 mg HYPERLINK https:/www.MedChemE/GlyRS-IN-1.html GlyRS-IN-1 HYPERLINK https:/www.MedChemE/GlyRS-IN-1.html HYPERLINK https:/www.MedChemE/Leu-AMS.html Leu-AMSCat. No.: HY-108940 Cat. No.: HY-108900GlyRS-IN-1 is a glycyl-tRNA synthas

15、e (GlyRS)inhibitor extracted from patent WO 2017066459 A1.GlyRS-IN-1 can also inhibit the growth of bacteria.Leu-AMS (compound 6), a leucine analogue, is apotent inhibitor of leucyl-tRNA synthetase (LRS)with an IC of 22.34 nM, which inhibits the50catalytic activity of LRS but did not affect theleuci

16、ne-induced mTORC1 activation.Purity: 98.14%Clinical Data: No Development ReportedSize: 5 mg, 10 mgPurity: 99.14%Clinical Data: No Development ReportedSize: 1 mg, 5 mg, 10 mg HYPERLINK https:/www.MedChemE/Leu-AMS_R_enantiomer.html Leu-AMS HYPERLINK https:/www.MedChemE/Leu-AMS_R_enantiomer.html HYPERL

17、INK https:/www.MedChemE/Leu-AMS_R_enantiomer.html R HYPERLINK https:/www.MedChemE/Leu-AMS_R_enantiomer.html HYPERLINK https:/www.MedChemE/Leu-AMS_R_enantiomer.html enantiomer HYPERLINK https:/www.MedChemE/Leu-AMS_R_enantiomer.html HYPERLINK https:/www.MedChemE/LysRs-IN-1.html LysRs-IN-1Cat. No.: HY-

18、108900A Cat. No.: HY-103280Leu-AMS R enantiomer is the R enatiomer ofLeu-AMS. Leu-AMS is a potent inhibitor ofleucyl-tRNA synthetase (LRS) and inhibits thegrowth of bacteria.LysRs-IN-1 is a Lysyl-tRNA synthetase (LysRs)inhibitor.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg2 Tel: 609-228-6898 Fax: 609-228-5909 Email: salesMedChemE HYPERLINK https:/www.MedChemE/lysrs-in-2.html LysRs-IN-2Cat. No.: HY-126130LysRs-I