Arecoline-hydrobromide-Arecoline-bromide-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEArecoline hydrobromideCat. No.: HY-B0489CAS No.: 300-08-3Synonyms: Arecoline bromide分式: CHBrNO分量: 236.11作靶點(diǎn): mAChR作通路: GPCR/G Protein; Neuronal Signaling儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)

2、體外實(shí)驗(yàn) H2O : 50 mg/mL (211.77 mM; Need ultrasonic)DMSO : 50 mg/mL (211.77 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 4.2353 mL 21.1766 mL 42.3531 mL5 mM 0.8471 mL 4.2353 mL 8.4706 mL10 mM 0.4235 mL 2.1177 mL 4.2353 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲

3、備液的保存式和期限。體內(nèi)實(shí)驗(yàn)請根據(jù)您的實(shí)驗(yàn)動物和給藥式選擇適當(dāng)?shù)娜芙獍福渲魄罢埾扰渲瞥吻宓膬湟?，再依次添加助溶?為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲備液可以根據(jù)儲存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (10.59 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)1/2 Master

4、 of Small Molecules 您邊的抑制劑師www.MedChemESolubility: 2.5 mg/mL (10.59 mM); Clear solution3. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 25 mg/mL (105.88 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Arecoline 氫溴酸鹽 (Arecoline bromide)毒蕈堿酰膽堿受體（mAChR）激動劑。REFERENCES1. Ghelardini, C., et al., M1 receptor activ

5、ation is a requirement for arecoline analgesia. Farmaco, 2001. 56(5-7): p. 383-5.2. Yang, Y.R., et al., Arecoline excites rat locus coeruleus neurons by activating the M2-muscarinic receptor. Chin J Physiol, 2000. 43(1):p. 23-8.3. Xie, D.P., et al., Arecoline excites the colonic smooth muscle motility via M3 receptor in rabbits. Chin J Physiol, 2004. 47(2): p. 89-94.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;