LX-1031 - Tryptophan Hydroxylase 抑制劑 - 生命科學試劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemELX-1031Cat. No.: HY-13041CAS No.: 945976-76-1分式: CHFNO分量: 538.52作靶點: Tryptophan Hydroxylase作通路: Metabolic Enzyme/Protease儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 34 mg/mL (63.14 mM)*

2、 means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 1.8569 mL 9.2847 mL 18.5694 mL5 mM 0.3714 mL 1.8569 mL 3.7139 mL10 mM 0.1857 mL 0.9285 mL 1.8569 mL請根據(jù)產品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 LX-1031種有效的，可服的 tryptophan 5-hydroxylase (TP

3、H) 抑制劑，能夠減少5-羥胺的合成。體內研究With oral administration of LX-1031 in mice, the average 5-HT reductions in the jejunum relative to controlare appr 33, 51, and 66% with the 15, 45 and 135 mg/kg/day doses respectively. In a preliminary report, theeffects of LX-1031, 100 mg/kg daily, on 5-HT levels in jejunal

4、mucosa are reversible within 2 days ofdiscontinuation in mice 1. LX-1031 dose-dependently reduces expression of 5-HT in the duodenum,1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEjejunum and ileum, but has no effect on brain 5-HT levels in preclinical assay 2.戶使本產品發(fā)表的科研獻 Cell Rep. 2019 Jul 16;28(

5、3):792-803.e4.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Camilleri M. LX-1031, a tryptophan 5-hydroxylase inhibitor, and its potential in chronic diarrhea associated with increased serotonin.Neurogastroenterol Motil. 2011 Mar;23(3):193-200.2. Camilleri M. LX-1031, a tryptophan 5-hydroxylase inhibitor that reduces 5-HT levels for the potential treatment of irritable bowelsyndrome. IDrugs. 2010 Dec;13(12):921-8.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-37