Mitotane-2-4-DDD-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEMitotaneCat. No.: HY-13690CAS No.: 53-19-0Synonyms: 2,4-DDD; o,p-DDD分式: CHCl分量: 320.04作靶點(diǎn): Others作通路: Others儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 100 mg/mL (312.46 mM)* means solu

2、ble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 3.1246 mL 15.6230 mL 31.2461 mL5 mM 0.6249 mL 3.1246 mL 6.2492 mL10 mM 0.3125 mL 1.5623 mL 3.1246 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn) 請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍福渲魄罢?qǐng)先配制澄清的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，

3、當(dāng)天使；澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (7.81 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (7.81 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTI

4、VITY物活性 Mitotane(2,4-DDD)DDD的同分異構(gòu)體和DDT的衍物，有抗癌活性，可作于腎上腺質(zhì)癌。REFERENCES1. Gentilin E, Tagliati F, Terzolo M, Mitotane reduces human and mouse ACTH-secreting pituitary cell viability and function. J Endocrinol.2013 Jul 29;218(3):275-285.2. Lehmann TP, Wrzesiski T, Jagodziski PP. The effect of mitotane on

5、 viability, steroidogenesis and gene expression in NCI H295Radrenocortical cells. Mol Med Rep. 2013 Mar;7(3):893-900.3. Takeshita A, Igarashi-Migitaka J, Koibuchi N, Mitotane induces CYP3A4 expression via activation of the steroid and xenobiotic receptor.J Endocrinol. 2013 Feb 15;216(3):297-305.4. E

6、derhy S, Cohen A, Dufaitre G, No evidence for relevant QT interval prolongation in mitotane-treated patients with adrenocorticalcarcinoma. J Endocrinol Invest. 2012 Nov;35(10):911-4.5. Alexandraki KI, Kaltsas GA, le Roux CW, Assessment of serum-free cortisol levels in patients with adrenocortical carcinoma treated withmitotane: a pilot study. Clin Endocrinol (Oxf). 2010 Mar;72(3):305-11.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Te