Linezolid-PNU-100766-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemELinezolidCat. No.: HY-10394CAS No.: 165800-03-3Synonyms: PNU-100766分式: CHFNO分量: 337.35作靶點: Bacterial作通路: Anti-infection儲存式: 4C, protect from light* In solvent : -80C, 6 months; -20C, 1 month (protect fromlight)溶解性數(shù)據(jù)體外實驗 DMSO : 1

2、00 mg/mL (296.43 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.9643 mL 14.8214 mL 29.6428 mL5 mM 0.5929 mL 2.9643 mL 5.9286 mL10 mM 0.2964 mL 1.4821 mL 2.9643 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實驗請根據(jù)您的實驗動物和給藥式選擇適當?shù)娜芙獍?，配制前請先配制澄清的儲備液，再依次添?/p>

3、助溶劑(為保證實驗結(jié)果的可靠性，體內(nèi)實驗的作液，建議您現(xiàn)現(xiàn)配，當天使；澄清的儲備液可以根據(jù)儲存條件，適當保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (7.41 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (7.41 mM); Clear solution3. 請依序添加每種溶劑： 10% D

4、MSO 90% corn oil1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemESolubility: 2.5 mg/mL (7.41 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Linezolid (PNU-100766)種合成的抗素，可于治療由對其他種抗素有抗藥性的蘭陽性菌引起的嚴重 感染。戶使本產(chǎn)品發(fā)表的科研獻 Acta Pharm Sin B. 2017, 52(6): 971-976. Front Microbiol. 2018 Sep 7;9:2095. Drug Des Devel Ther

5、. 2018 Jun 11;12:1679-1684.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Clemett D, Markham A. Linezolid. Drugs. 2000 Apr;59(4):815-27; discussion 828.2. Chiappini E, Conti C, Galli L et al. Clinical efficacy and tolerability of linezolid in pediatric patients: a systematic r

6、eview. Clin Ther. 2010Jan;32(1):66-88.3. Perry CM, Jarvis B. Linezolid: a review of its use in the management of serious gram-positive infections. Drugs. 2001;61(4):525-51.4. He MZ, Jiang YW, Cai C.Mechanisms and epidemiology of linezolid resistance in staphylococci.Zhonghua Jie He He Hu Xi Za Zhi.

7、2012May;35(5):360-2.5. Karau MJ, Tilahun AY, Schmidt SM, Clark CR, Patel R, Rajagopalan G.Linezolid is Superior to Vancomycin in Experimental PneumoniaCaused by Superantigen-Producing Staphylococcus aureus in HLA class II Transgenic Mice.Antimicrob Agents Chemother. 2012 Jul 30.McePdfHeightCaution: Product has not been fully validated for medical applications.For research us