EMT-inhibitor-1 - Hippo (MST) 抑制劑 - 生命科學(xué)試劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEEMT inhibitor-1Cat. No.: HY-101275CAS No.: 1638526-21-2分式: CHClNOS分量: 319.21作靶點: Hippo (MST); TGF-beta/Smad; Wnt作通路: Stem Cell/Wnt; TGF-beta/Smad儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMS

2、O : 100 mg/mL (313.27 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 3.1327 mL 15.6637 mL 31.3273 mL5 mM 0.6265 mL 3.1327 mL 6.2655 mL10 mM 0.3133 mL 1.5664 mL 3.1327 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實驗請根據(jù)您的實驗動物和給藥式選擇適當?shù)娜芙獍?，配制前請先配制澄清的儲備液?/p>

3、再依次添加助溶劑(為保證實驗結(jié)果的可靠性，體內(nèi)實驗的作液，建議您現(xiàn)現(xiàn)配，當天使；澄清的儲備液可以根據(jù)儲存條件，適當保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (7.83 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (7.83 mM); Clear solution3. 請依序添加每種溶劑：

4、10% DMSO 90% corn oil1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemESolubility: 2.5 mg/mL (7.83 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 EMT inhibitor-1是Hippo，TGF- 和 Wnt 信號通路的抑制劑，并擁有抗腫瘤活性。IC50 & Target Hippo, TGF-, Wnt 1.體外研究 EMT inhibitor-1 (C19) is an inhibitor of of Hippo, TGF-, and Wnt signal

5、ing pathways with antitumor activities,inhibiting cancer cell migration, proliferation, and resistance to doxorubicin in vitro 1.體內(nèi)研究 EMT inhibitor-1 (C19) exerts strong antitumor activity in a mouse tumor model. Mechanistically, EMTinhibitor-1 induces GSK3-mediated degradation of the Hippo transduc

6、er TAZ, through activation of theHippo kinases Mst/Lats and the tumor suppressor kinase AMPK upstream of the degradation complex 1.REFERENCES1. Basu D, et al. Identification, mechanism of action, and antitumor activity of a small molecule inhibitor of hippo, TGF-, and Wnt signalingpathways. Mol Cancer Ther. 2014 Jun;13(6):1457-67.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: