N-desmethyl-Enzalutamide-N-desmethyl-MDV-3100-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEN-desmethyl EnzalutamideCat. No.: HY-70002ACAS No.: 1242137-16-1Synonyms: N-desmethyl MDV 3100分式: CHFNOS分量: 450.41作靶點(diǎn): Androgen Receptor作通路: Others儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) D

2、MSO : 48 mg/mL (106.57 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 2.2202 mL 11.1010 mL 22.2020 mL5 mM 0.4440 mL 2.2202 mL 4.4404 mL10 mM 0.2220 mL 1.1101 mL 2.2202 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 N-desmethyl Enza

3、lutamide(N-desmethyl MDV3100)是Enzalutamide(MDV3100)的主要代謝物。IC50 & Target Androgen-receptor 1體內(nèi)研究N-desmethyl Enzalutamide is an active metabolite that is thought to contribute to the clinical effects of1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEEnzalutamide because it demonstrates primary and se

4、condary pharmacodynamics of similar potency toEnzalutamide and circulates at approximately the same plasma concentrations as Enzalutamide. Thecarboxylic acid metabolite is pharmacologically inactive and circulates at approximately 25 % lower plasmaconcentrations than Enzalutamide 1.REFERENCES1. Gibbons JA, et al. Pharmacokinetic Drug Interaction Studies with Enzalutamide. Clin Pharmacokinet. 2015 Oct;54(10):1057-69.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;/p>