Cimetidine-SKF-92334-DataSheet-生命科學試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemECimetidineCat. No.: HY-14289CAS No.: 51481-61-9Synonyms: SKF-92334分式: CHNS分量: 252.34作靶點: Histamine Receptor作通路: GPCR/G Protein; Immunology/Inflammation; NeuronalSignaling儲存式: Powder -20C 3 years4C 2 years* 該產品在溶液狀態(tài)不穩(wěn)定，建議您現(xiàn)現(xiàn)配，即刻使

2、。溶解性數據體外實驗 H2O : 2 mg/mL (7.93 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 3.9629 mL 19.8145 mL 39.6291 mL5 mM 0.7926 mL 3.9629 mL 7.9258 mL10 mM - - -請根據產品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液；該產品在溶液狀態(tài)不穩(wěn)定，建議您現(xiàn)現(xiàn)配，即刻使。BIOLOGICAL ACTIVITY物活性 CimetidineH2受體拮抗劑。戶使本產品發(fā)表的科研獻1/2 Master of Smal

3、l Molecules 您邊的抑制劑師www.MedChemE Chemosphere. 2019 Mar.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Takahashi, H.K., et al., Cimetidine induces interleukin-18 production through H2-agonist activity in monocytes. Mol Pharmacol, 2006.70(2): p. 450-3.2. Sprowl, J.A., et al., Con

4、junctive therapy of cisplatin with the OCT2 inhibitor cimetidine: influence on antitumor efficacy and systemicclearance. Clin Pharmacol Ther, 2013. 94(5): p. 585-92.3. Zheng, Y., et al., Cimetidine suppresses lung tumor growth in mice through proapoptosis of myeloid-derived suppressor cells. MolImmu

5、nol, 2013. 54(1): p. 74-83.4. Fukuda, M., K. Kusama, and H. Sakashita, Cimetidine inhibits salivary gland tumor cell adhesion to neural cells and induces apoptosisby blocking NCAM expression. BMC Cancer, 2008. 8: p. 376.5. Longhini, R., et al., Cimetidine Reduces the Alveolar Bone Loss in Induced Periodontitis in Rat Molars. J Periodontol, 2013.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 0