Z-Lanoconazole-DataSheet-生命科學(xué)試劑-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?Agonists?ScreeningLibrarieswww.MedChemE(Z)-LanoconazoleCat.No.:HY-14282A分?式:C??H??ClN?S?分?量:319.83作?靶點:Fungal作?通路:Anti-infection儲存?式:PleasestoretheproductundertherecommendedconditionsintheCOA.BIOLOGICALACTIVITY?物活性(Z)-LanoconazoleLanoconazole的Z構(gòu)型形式。Lanoconazole?種強效?服咪唑類抗真(antifungal)試劑，具有?譜的體內(nèi)外抗真活性。Lanoconazole通過抑制sterol14-alpha去甲酶，阻斷真膜上的ergosterol?物合成，從??擾ergosterol的?物合成。Lanoconazole可?于?膚真病和甲真病的研究。IC50&TargetIC50:antifungal[1]體內(nèi)研究ressthleprtriotfoneuror;phhe-3motctictorsossuts,

inflammatoryprotein-2,andinhibitedneutrophilinfiltrationtotheinflammationsite[2].Lanoconazole(oral

administration;3,10or30mg/kg;onceaday;3weeks)significantlyinhibitsC.neoformanscomparedwiththesaline

controlinnormalmice.Inaddtion,itsignificantlyreducesthegrowthofC.neoformansinthelungsandbrainsof

MAIDSmice[3].REFERENCES[1].ShokoohiGR,etal.InVitroActivitiesofLuliconazole,Lanoconazole,andEfinaconazoleComparedwithThoseofFiveAntifungalDrugsagainstMelanizedFungiandRelatives.AntimicrobAgentsChemother.2017Oct24;61(11).pii:e00635-17.[2].NakamuraA,etal.Anti-inflammatoryeffectoflanoconazoleon12-O-tetradecanoylphorbol-13-acetate-and2,4,6-trinitrophenylchloride-inducedskininflammationinmice.Mycoses.2020Feb;63(2):189-196.[3].FurukawaK,etal.Lanoconazole,anewimidazoleantimycoticcompound,protectsMAIDSmiceagainstencephalitiscausedbyCryptococcusneoformans.JAntimicrobChemother.2000Sep;46(3):443-50.1/2MasterofSmallMolecules—您?邊的抑制劑?師www.MedChemEMcePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;0