β-Aminopropionitrile-DataSheet-生命科學(xué)試劑-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?Agonists?ScreeningLibrarieswww.MedChemEβ-AminopropionitrileCat.No.:HY-Y1750CASNo.:151-18-8分?式:C?H?N?分?量:70.09作?靶點(diǎn):MonoamineOxidase作?通路:NeuronalSignaling儲存?式:4°C,protectfromlight*Insolvent:-80°C,6months;-20°C,1month(protectfrom

light)溶解性數(shù)據(jù)體外實(shí)驗DMSO:130mg/mL(1854.76mM;Needultrasonic)H2O:50mg/mL(713.37mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM14.2674mL71.3369mL142.6737mL5mM2.8535mL14.2674mL28.5347mL10mM1.4267mL7.1337mL14.2674mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存?式和期限。體內(nèi)實(shí)驗請根據(jù)您的實(shí)驗動物和給藥?式選擇適當(dāng)?shù)娜芙?案，配制前請先配制澄的儲備液，再依次添加助溶劑(為保證實(shí)驗結(jié)果的可靠性，體內(nèi)實(shí)驗的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；澄的儲備液可以根據(jù)儲存條件，適當(dāng)保存；以下溶劑前的百分?指該溶劑在您配制終溶液中的體積占?)：1.請依序添加每種溶劑：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥3.25mg/mL(46.37mM);Clearsolution2.請依序添加每種溶劑：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥3.25mg/mL(46.37mM);Clearsolution3.請依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥3.25mg/mL(46.37mM);Clearsolution1/2MasterofSmallMolecules—您?邊的抑制劑?師www.MedChemEBIOLOGICALACTIVITY?物活性β-Aminopropionitrile?種特異的不可逆賴氨酰氧化酶(LOX)抑制劑。β-Aminopropionitrile靶向LOX或LOXL同?酶的活性位點(diǎn)。IC50&TargetHumanEndogenousMetabolite(批量添加)體外研究β-Aminopropionitrileblocksthehypoxia-inducedEMTmorphologicalandmarkerproteinchanges,andinhibitedinvasionandmigrationcapacitiesofcervicalcarcinomacellsinvitro[2].REFERENCES[1].MianaM,etal.Thelysyloxidaseinhibitorβ-aminopropionitrilereducesbodyweightgainandimprovesthemetabolicprofileindiet-inducedobesityinrats.DisModelMech.2015Jun;8(6):543-51.[2].YangX,etal.Inactivationoflysyloxidasebyβ-aminopropionitrileinhibitshypoxia-inducedinvasionandmigrationofcervicalcancercells.OncolRep.2013Feb;29(2):541-8.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-8