HeE1-2Tyr-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEHeE1-2TyrCat.No.:HY-100749CASNo.:2245195-67-7分?式:C??H??N?O?S分?量:582.67作?靶點(diǎn):SARS-CoV作?通路:Anti-infection儲(chǔ)存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:100mg/mL(171.62mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM1.7162mL8.5812mL17.1624mL5mM0.3432mL1.7162mL3.4325mL10mM0.1716mL0.8581mL1.7162mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；?旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲(chǔ)備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?。BIOLOGICALACTIVITY?物活性HeE1-2Tyr?種pyridobenzothiazole，?種病毒RNA依賴性RNA聚合酶(RdRp)抑制劑。HeE1-2Tyr在體外顯抑制西尼羅河、登?熱和SARS-CoV-2RdRps(IC50為27.6μM)的活性。IC50&TargetFlavivirusRNAdependentRNApolymerases(RdRp)[1]SARS-CoV-2RdRps>[2]1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE體外研究HeE1-2Tyrshowsantiviralactivity,itisabletoinhibitanUgandanstrainofWestNileviruswithanIC50of2.1μM,aswellasallthefourDenguevirus(DENV)serotypes,withIC50rangingfrom6.8to15μM.ThecytotoxicityofHeE1-2TyrversusVeroE6cellsis~115μM[1].Additionally,uponinfectionofhumanHEK293cells(CC50of50μM),HeE1-2TyrinhibitsclinicalstrainsofyellowfeverviruswithIC50valuesrangingfrom3.9to12μM[1].HeE1-2TyrcompletelyinhibitsthereplicationofbothSARS-CoV-2andFelinecoronavirus(FIPV)[2].REFERENCES[1].DeliaTarantino,etal.TargetingflavivirusRNAdependentRNApolymerasethroughapyridobenzothiazoleinhibitor.AntiviralRes.2016Oct;134:226-235.[2].MilanDejmek,etal.Non-NucleotideRNA-DependentRNAPolymeraseInhibitorThatBlocksSARS-CoV-2Replication.Viruses.2021Aug11;13(8):1585.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792