TH1338-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemETH1338Cat.No.:HY-120574CASNo.:1258494-60-8分?式:C??H??N?O?分?量:391.42作?靶點(diǎn):Others作?通路:Others儲(chǔ)存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:10mg/mL(25.55mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM2.5548mL12.7740mL25.5480mL5mM0.5110mL2.5548mL5.1096mL10mM0.2555mL1.2774mL2.5548mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；?旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲(chǔ)備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥?式選擇適當(dāng)?shù)娜芙?案。以下溶解?案都請(qǐng)先按照InVitro?式配制澄的儲(chǔ)備液，再依次添加助溶劑：(為保證實(shí)驗(yàn)結(jié)果的可靠性，澄的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過(guò)程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過(guò)加熱和/或超聲的?式助溶)1.請(qǐng)依序添加每種溶劑：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥1.82mg/mL(4.65mM);Clearsolution1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEBIOLOGICALACTIVITY?物活性TH1338(compound3b)具有?服活性的喜樹(shù)堿的衍?物，有潛?的抗癌化合物，在體外表現(xiàn)出優(yōu)異的腫瘤細(xì)胞毒性的效果。TH1338(compound3b)具有顯著的?腦屏障透過(guò)性，良好的外排泵特性和低?液學(xué)毒性。體外研究TH1338(compound3b)demonstratessignificantbrainpenetrationwhendosedorallyinmice[1].TH1338(compound3b)exhibitspotentanti-tumoractivityinH460(NSCLC)humantumorxenograftmodel[1].CellViabilityAssay[1]CellLine:H460(NSCLC)humantumorxenograftmodel.Concentration:40mg/kg.IncubationTime:Oralgavage.Result:Exhibitedsuperiorantitumoractivity.REFERENCES[1].Jian-XinDuan,etal.14-Aminocamptothecins:theirsynthesis,preclinicalactivity,andpotentialuseforcancertreatment.JMedChem.2011Mar24;54(6):1715-23.[2].XiaCheng,etal.Preparation,Characterization,andInVivoStudyof7-Ethyl-14-Aminocamptothecin-LoadedPoly(EthyleneGlycol)2000-Poly(LacticAcid)2000PolymericMicellesAgainstH460HumanNonsmallCellLungCarcinoma.JPharmSci.2015Nov;104(11):3934-3942.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-8