獸醫(yī)師貓傳染病專題-中文5fcv esavs katrin

ViralCausesofUpperRespiratoryTractFelineKatrinProf.Dr.med.vet.,Dr.habil.,Dipl.ECVIM- 3yearsold

maleneuteredsinglecathouseholdindooronlyregularlyvaccinated,completeprimo-vaccinationlastvaccination4months Historysince1dayproblemstostanguriatodayanorecticphysicallargeandtenseDiagnosis

Treatmentindwellingcatheteremptyingofthebladderfluidtherapy(incl.electrolytepainfollow-upngbettershortlyafterstartedeatingcatheterleftinfor24thenextthenextdaynewocularnasalulcerationsontheulcerationsonthe2424hourslater 242424hourslater 242424hourslater 24WhatistheprobleminWhatistheprobleminthesecats?這些貓有什么問(wèn)題

=feline =felines =feline-Chlamydophila- la-Mykoplasmaspp.(e.g.M.-other

oculardisch.nasaldisch. ++-++++--+++-+---++----+--++-++++--+++-+---+---++--WhatWhatisthediagnosticIsitimportanttofindtheunderlyingdiagnostictooltodetectmultiple檢測(cè)多重病原體的診斷工multiplex

多重ChymydophilafelisMaterial病conjunctival oralswabs(ulcerativelesions口腔拭子（潰瘍面retropharyngealswabsswabs(tongue,=>multiplexPCR(FCV,FHV,Chlamydophilaisolation(forFCV)incell細(xì)胞培養(yǎng)以進(jìn) swabs(tongue,positiveforFCVisolationincell=>positiveforFeline

small,小體型，無(wú)囊膜withcup-likehighserological

strainswithdifferentandupperrespiratory Lateincalyx= Lateincalyx= Lateincalyx= FCVEpidemiologycarrier

byoralandnasaldischarge,(fewdaysuptolife-longperiod)數(shù)日generallydirect,通常直接indirecttransmissionpossiblerelativelystableinthe環(huán)境中相對(duì)穩(wěn)定（三周）(upto3replicationintonsillsLymphoepithelialtissue susceptibleself- susceptibleself-catwithacutecatwithacuteFCV40%colony25%show8%household20%practiceorlife-50%cats50%catsstill75dayspostnon-manycatsdaysafterGaskell&Bennett, FCV或急性或急性2030日后排Gaskell&Bennett,FCVClinicalSignssneezing,sneezing,nasal96conjunctivitis,ocular71lymphocytic/plasmocytic29??MacLachlan&Burgess,cough(rarely lameness kitten跛行（“小貓?zhí)S綜合癥virulentsystemicfeline disease貓卡里 AcuteOral急性口腔損 AcuteOral急性口腔損 KittenSyndromePedersenetal.,小貓?zhí)S綜合mainlyinkittensof6-12主要見(jiàn)于6- 的小oftenafter常發(fā) 免疫usuallyintermittentoftenwithfevermostlyself-limitingcertainantigenic特定抗原變異relatedto 相關(guān)replicationin在關(guān)節(jié) immune- 免疫介導(dǎo)increasedina1-acida1-酸性糖蛋白增VirulentSystemicFelinerecentlydescribedsyndromePedersenetal.,severesystemichemorrhagic high noprotectionbycommon普 無(wú)保護(hù)ChronicProliferative

proliferative immune-mediatedreactiontochronicFCV roleofchronicroleofFIVand

FIV和FeLV的角detectionofdetectiondetectionofdetectionnotusefulantigenicsensitiveand isolation(cellsensitiveand-FCVFCV–TreatmentSupportiveNutrition*diazepamValium?0.05-0.25mg/kgIV(immediate0.25-0.5mg/kgq12hPO(longer*cyproheptadine(Peritol?)賽庚

0.51mg/kgq12hPOlongerapplicationvitaminA5000IU/kgq24hvitaminC80mg/kgq8hvitaminBcomplexq48hAntiviral 藥

noeffect無(wú) W

someeffect?

Uchinoetantiviral 效 ogue(guanosine核苷類似物（鳥(niǎo)嘌呤核苷衍生物 interfereswithDNAandmRNA干擾DNA和mRNA合Dosage 11mg/kgq24hPOorIV(max.7 onlyincombinationwithinterferon-a/worin只可以與a/w干擾素合用或放在 中給Spectrum抗毒 infection?卡里sideeffects(alreadyintherapeuticdosage副作 骨髓抑制，肝毒 腹瀉，胃腸道潰Interferon-ωωhumaninterferon-a,felineinterferon-antiviral 效 assemlyand cytokine,immunomodulatory huIFN-ahighdose105IU/kgq24hSQ(short huIFN-alowdose1(-50)IUq24hPO(long feIFN-w106IU/kgSQq24hon5consecutivedays連續(xù)五Spectrum infectionssideeffects rarelyallergicreactions(huIFN-Interferon-ωinAcuteFCV急性 時(shí)應(yīng)用ω干擾fieldstudyUhinoetal.,

實(shí)地研究 160catswithURTDorstomatitis160只患上呼吸道疾病或口炎的multi-centernoFCV

多中心研無(wú)FCV診斷特notcontrolled,allcatsreceivedsymptomatic無(wú)對(duì)照組，所有貓均接受全身用felinesinterferon-ω2.5or5x106IU/kgIVq24hfor3貓干擾素連用三<4daysaftersignshadimprovementofclinicalsigns?Interferon-ωinChronicStomatitistreatmentwithinterferon-用wMihaljevic,sofarnoplacebo-controlledfelineinterferon-w2.5x106injectionofseveraldepotsof0.1ml(gingiva)+leftoverSQtreatmentrepeatedifnecessary0.1ml在齒齦內(nèi)多點(diǎn)注射，其他的皮下注射，按需反復(fù)給important:properdentalImmunoglobulinsImmunoglobulinsantiviraleffects 效 neutralizing特 毒中和抗Dosage forprophylaxissingleinjection皮下注射，預(yù)防性單次注 fortreatment3xSQ(3consecutive治療：連續(xù)注射三Spectrum , ,細(xì) ，皰 ，卡里sideeffects副作 anaphylacticreactionincats(repeated反復(fù)使用可能導(dǎo)致過(guò)敏反broadspectrumfluidtherapyInhalationNutritionmucolytics:bromhexin,痰液溶解劑：溴己新，乙酰半胱氨immunoglobulins(antibodiesagainst免疫球蛋白（FCV抗體follow-uphighfever,DIC,anemia,highliverbroadspectrumfluidtherapyInhalationNutritionmucolytics:bromhexin,痰液溶解劑：溴己新，乙酰半胱氨immunoglobulins(antibodiesagainst免疫球蛋白（FCV抗體follow-uphighfever,DIC,anemia,highliver7272HoursLater “B?rli”7272HoursLater ??????Managementof nocatsintheclinic診所內(nèi)無(wú)blockingfor21days(afterlast21天（最后一只 后Hygiene衛(wèi)生工cleaninganddisinfectionofcages,bowls,籠具，食盆清潔，滅isolationofdiseased患病動(dòng)identificationandisolationoflong-term鑒別 長(zhǎng)期排毒prophylacticimmunoglobulintreatment免疫球蛋白預(yù)防性治neutralizingantibodiesagainstFCV中和抗1injectionbeforeenteringclinicorboarding進(jìn)入診所或住院前注射一Problemswith的問(wèn)nocompleteprotectionagainst無(wú)法對(duì)疾病形成完全保onlyagainstdevelopmentofclinicalnopreventionofcolonizationofmucous noprotectionagainstcarriernopreventionof無(wú)法防 脫onlyprotectionagainstfewFCV-只可以對(duì)抗少量FCV毒already>50%ofcats仍有大于50%NeutralisationofVaccineexaminationofvaccine FCVG1andFCV431FCVF9andFCV255(oldvaccineneutralisationtestwith110FCVisolatesfrom=>newvaccinestrains新 effectiveaga