Pim-1-2-kinase-inhibitor-1-DataSheet-生命科學試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEPim-1/2kinaseinhibitor1Cat.No.:HY-W412264CASNo.:6320-51-0分?式:C??H?NO?S分?量:235.26作?靶點:Pim作?通路:JAK/STATSignaling儲存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實驗DMSO:250mg/mL(1062.65mM;ultrasonicandwarmingandheatto60°C)MassSolvent1mg5mg10mgConcentration制備儲備液1mM4.2506mL21.2531mL42.5062mL5mM0.8501mL4.2506mL8.5012mL10mM0.4251mL2.1253mL4.2506mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲存時，請在6個?內(nèi)使?，-20°C儲存時，請在1個?內(nèi)使?。BIOLOGICALACTIVITY?物活性Pim-1/2kinaseinhibitor1?種?服有效的Pim-1/2激酶抑制劑。Pim-1/2kinaseinhibitor1能阻斷Pim激酶對肽的磷酸化能?，并且抑制4E-BP1和p27Kip1的Pim蛋?激酶定向磷酸化。Pim-1/2kinaseinhibitor1可?于癌癥，尤其前列腺癌的研究。體外研究Pim-1/2kinaseinhibitor1(compoundD14)(varyingconcentrations;48h)showscytotoxicitytoPC3cells,1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEwithanICof11μM[1].CellCytotoxicityAssay[1]CellLine:PC3cellsConcentration:varyingconcentrationsIncubationTime:48hResult:InhibitedPC3cellswithanICof11μM.REFERENCES[1].CharlesD.Smith,etal.InhibitorsofPIM-1ProteinKinases,CompositionsandMethodsforTreatingProstateCancer.PatentUS20110263664A1.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax:0