Shishijimicin-A-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEShishijimicinACat.No.:HY-N10537CASNo.:503860-50-2分?式:C??H??N?O??S?分?量:981.18作?靶點:Others作?通路:Others儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性ShishijimicinA?種新型的抗腫瘤劑，它從?囊Didemnumproliferum中發(fā)現(xiàn)的。ShishijimicinA表現(xiàn)出抗腫瘤活性，具有?度的細(xì)胞毒性。體外研究ShishijimicinA(compound1)(0.47-2.0pg/mL)showshighcytotoxicityfor3Y1,HelaandP388cells[1].ShishijimicinA(0.13-1000nM)showshighcytotoxicityforMESSA,MESSADXandHEK293Tcells[2].CellCytotoxicityAssay[1]CellLine:3Y1,HelaandP388cellsConcentration:0.47-2.0pg/mLIncubationTime:Result:ShowedIC50valuesof2.0,1.8,and0.47pg/mLfor3Y1,HelaandP388cells,respectively.CellCytotoxicityAssay[2]CellLine:MESSA,MESSADXandHEK293TcellsConcentration:0.13-1000nMIncubationTime:Result:ShowedIC50valuesof0.13,>1000,and0.016nMforMESSA,MESSADXandHEK1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE293Tcells,respectively.REFERENCES[1].NaoyaOku,etal.ShishijimicinsA-C,novelenediyneantitumorantibioticsfromtheascidianDidemnumproliferum(1).JAmChemSoc.2003Feb26;125(8):2044-5.[2].KCNicolaou,etal.StreamlinedTotalSynthesisofShishijimicinAandItsApplicationtotheDesign,Synthesis,andBiologicalEvaluationofAnaloguesthereofandPracticalSynthesesofPhthNSSMeandRelatedSulfenylatingReagents.JAmChemSoc.2018Sep26;140(38):12120-12136.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-58955