2-Chloropyridin-4-yl-methanamine-hydrochloride-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemE(2-Chloropyridin-4-yl)methanaminehydrochlorideCat.No.:HY-101771ACASNo.:916210-98-5分?式:C?H?Cl?N?分?量:179.05作?靶點:MonoamineOxidase作?通路:NeuronalSignaling儲存?式:4°C,sealedstorage,awayfrommoisture*Insolvent:-80°C,6months;-20°C,1month(sealed

storage,awayfrommoisture)溶解性數(shù)據(jù)體外實驗H2O:≥50mg/mL(279.25mM)DMSO:≥33mg/mL(184.31mM)*"≥"meanssoluble,butsaturationunknown.MassSolvent1mg5mg10mgConcentration制備儲備液1mM5.5850mL27.9252mL55.8503mL5mM1.1170mL5.5850mL11.1701mL10mM0.5585mL2.7925mL5.5850mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month(sealedstorage,awayfrommoisture)。-80°C儲存時，請在6個?內(nèi)使?，-20°C儲存時，請在1個?內(nèi)使?。體內(nèi)實驗請根據(jù)您的實驗動物和給藥?式選擇適當(dāng)?shù)娜芙?案。以下溶解?案都請先按照InVitro?式配制澄的儲備液，再依次添加助溶劑：(為保證實驗結(jié)果的可靠性，澄的儲備液可以根據(jù)儲存條件，適當(dāng)保存；體內(nèi)實驗的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的?式助溶)1.請依序添加每種溶劑：PBSSolubility:100mg/mL(558.50mM);Clearsolution;Needultrasonic1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEBIOLOGICALACTIVITY?物活性(2-Chloropyridin-4-yl)methanaminehydrochloride選擇性的LOXL2抑制劑，IC50值為126nM。IC50&TargetIC50:126nM(LOXL2)[1]體外研究(2-Chloropyridin-4-yl)methanaminehydrochlorideisshowntobeselectiveforLOXL2overLOXandthreeotheramineoxidases(MAO-A,MAO-BandSSAO).InthehumanwholebloodLOXL2assay,(2-Chloropyridin-4-yl)methanaminehydrochloridehasanIC50of1.45μMcomparedto126nMintheabsenceofbloodproteins.(2-Chloropyridin-4-yl)methanaminehydrochlorideshowsa31-foldselectivityforLOXL2+BSA(IC50=190nM)overLOX+BSA(IC50=5.91μM).Againstapanelofnon-LTQ-containingAOenzymes(MAO-A,MAO-BandSSAO),LOXL2-IN-1isfoundtobeinactiveat30μM.(2-Chloropyridin-4-yl)methanaminehydrochlorideisprofiledfortheinhibitionofthreedifferentCYPenzymes(CYPs3A4,2C9and2D6)andineachcasetheIC50ismorethan30μM[1].戶使?本產(chǎn)品發(fā)表的科研?獻(xiàn)?AgingCell.2022Jun17;e13659.?OncolRep.2020May;43(5):1641-1649.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].HutchinsonJH,etal.SmallMoleculeLysylOxidase-like2(LOXL2)Inhibitors:TheIdentificationofanInhibitorSelectiveforLOXL2overLOX.ACSMedChemLett.2017Mar1;8(4):423-427.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresea