Rezafungin-acetate-Biafungin-acetate-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemERezafunginacetateCat.No.:HY-108009ACASNo.:1631754-41-0Synonyms:Biafunginacetate;CD101acetate;SP-3025acetate分?式:C??H??N?O??分?量:1285.44作?靶點(diǎn):Fungal作?通路:Anti-infection儲存?式:4°C,sealedstorage,awayfrommoisture*Insolvent:-80°C,6months;-20°C,1month(sealed

storage,awayfrommoisture)溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:230mg/mL(178.93mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM0.7779mL3.8897mL7.7794mL5mM0.1556mL0.7779mL1.5559mL10mM0.0778mL0.3890mL0.7779mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month(sealedstorage,awayfrommoisture)。-80°C儲存時(shí)，請?jiān)?個(gè)?內(nèi)使?，-20°C儲存時(shí)，請?jiān)?個(gè)?內(nèi)使?。體內(nèi)實(shí)驗(yàn)請根據(jù)您的實(shí)驗(yàn)動物和給藥?式選擇適當(dāng)?shù)娜芙?案。以下溶解?案都請先按照InVitro?式配制澄的儲備液，再依次添加助溶劑：(為保證實(shí)驗(yàn)結(jié)果的可靠性，澄的儲備液可以根據(jù)儲存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的?式助溶)1.請依序添加每種溶劑：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥5.75mg/mL(4.47mM);Clearsolution1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE2.請依序添加每種溶劑：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥5.75mg/mL(4.47mM);Clearsolution3.請依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥5.75mg/mL(4.47mM);ClearsolutionBIOLOGICALACTIVITY?物活性Rezafungin(Biafungin)下?代，?譜且持久的棘?素。Rezafunginacetate顯?對念珠，曲霉和肺孢?具有有效的抗真活性。體內(nèi)研究Rezafunginacetate(Biafunginacetate)(1mg/kg;i.p.oncedailyfor6days)showspotentinvivoefficacyasprophylaxisagainstPneumocystisinaninvivomouseinfectionmodel[1].AnimalModel:C3H/HeNmice[1]Dosage:1mg/kgAdministration:Intraperitonealinjection;oncedailyfor6daysResult:Significantlyreducednucleiandasciburdens.REFERENCES[1].MelanieCushion,etal.RezafunginProphylacticEfficacyinaMouseModelofPneumocystisPneumonia.VOLUME25,ISSUE3,SUPPLEMENT,S366,MARCH01,2019.[2].SofjanAK,etal.Rezafungin(CD101),anext-generationechinocandin:Asystematicliteraturereviewandassessmentofpossibleplaceintherapy.JGlobAntimicrobResist.2018Sep;14:58-64.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly