藥學(xué)英語(yǔ)之減肥藥原理講解

GenericName:Sibutraminehydrochloride

ProductName:Reductil/EctivaProductname:QuMeiGenericName:

Sibutraminehydrochloride

SibutramineFormula:

C17H26ClN

molecule

ChemicalstructureIndications:

obesity(肥胖癥，多脂)?。?！

pharmacologySibutramineisaneurotransmitter(神經(jīng)遞質(zhì))reuptake（重吸收）inhibitorthatreducesthereuptakeofserotonin（血清素),norepinephrine（去甲腎上腺素）,anddopamine,therebyincreasingthelevelsofthesesubstancesinsynapticclefts（突觸間隙）andhelpingenhancesatiety（飽滿感）;theserotonergic（5-羥色胺能）action,inparticular,isthoughttoinfluenceappetite.

contraindicationsSibutramineiscontraindicatedin:1Psychiatric(精神病學(xué)旳)conditionsasbulimianervosa（神經(jīng)性貪食癥）,anorexia（厭食癥）,seriousdepressionorpreexistingmania（狂躁癥）2Patientsbelow18yearsofage3Concomitant（伴行旳，并發(fā)旳）treatmentwithaMAOinhibitor（單胺氧化酶克制劑）,antidepressantorothercentrallyactivedrugs,particularlyotheranoretics（消瘦劑，減食欲劑）4Hypertensionthatisnotsufficientlycontrolled(cautionincontrolledhypertension)5Existingpulmonaryhypertension（肺動(dòng)脈高血壓）6Pregnantandlactating（泌乳）women

sideeffects!!Frequentlyencounteredsideeffectsare:drymouth,paradoxicallyincreasedappetite,nausea(惡心),strangetasteinthemouth,upsetstomach,constipation（便秘）,troublesleeping,dizziness,drowsiness（困倦）,menstrualcramps/pain,headache,flushing（面紅）,orjoint/musclepain.Thefollowingsideeffectsareinfrequentbutseriousandrequireimmediatemedicalattention:

cardiacarrhythmias（心律不齊）,paresthesia（感覺(jué)異常）,mental/moodchanges(e.g.,excitement,restlessness,confusion,depression,rarethoughtsofsuicide).Symptomsthatrequireurgentmedicalattentionare

seizures（癲癇發(fā)作）,problemsurinating（排尿）,abnormalbruising（碰傷）orbleeding,hematemesis（嘔血）,feverandrigors（僵直）,chestpain,hemiplegia,（半身不遂）abnormalvision,dyspnea（呼吸困難）andedema.（水腫）Suggestion!!Don’ttakeQUMeioranykindofmedicinewhosemainingredientisSibutramine.Moreexerciseandlessfoodi