ASL腦灌注成像技術(shù)臨床應(yīng)用及研究進(jìn)展

3D

ASL腦灌注成像技術(shù)臨床應(yīng)用與研究進(jìn)展

1整理ppt提綱3DASL研究進(jìn)展2整理ppt腦灌注成像研究方法采用可彌散的示蹤劑進(jìn)行成像的方法15O-WaterPETXenonCTASLMRI99Tc-HMPAOSPECT（Microsphere-liketracers）采用不可彌散的示蹤劑進(jìn)行成像的方法CTPDSCMRI3整理ppt采用可彌散的示蹤劑進(jìn)行成像的方法15O-WaterPET放射性損傷、成本高XenonCT放射性損傷、舒適性差A(yù)SLMRI99Tc-HMPAOSPECT（Microsphere-liketracers）放射性損傷、半定量采用不可彌散的示蹤劑進(jìn)行成像的方法CTPDSCMRI腦灌注成像研究方法4整理pptASL成像技術(shù)PulsedASL(PASL)脈沖式ContinuousASL(CASL)連續(xù)式Pseudo-continuousASL(PCASL)準(zhǔn)連續(xù)式SNRACCURACYSARPASL+++++CASL+++++++PCASL++++++++5整理ppt傳統(tǒng)ASL與3D

ASL對(duì)比

3DASL

傳統(tǒng)ASL采用EPI采集，磁敏感偽影明顯2D采集，成像范圍有限對(duì)運(yùn)動(dòng)偽影敏感采用FSE采集，有效克服磁敏感偽影3D采集，大范圍成像Spiral采集高效快速，有效克服運(yùn)動(dòng)偽影圖像信噪比明顯提高圖像質(zhì)量不穩(wěn)定6整理ppt提綱3DASL臨床應(yīng)用7整理ppt3D

ASL臨床應(yīng)用--腫瘤鑒別腦膜瘤海綿狀血管瘤301病例8整理ppt3D

ASL臨床應(yīng)用--腫瘤分級(jí)星形細(xì)胞瘤,WHOII級(jí)星形細(xì)胞瘤,WHOIII級(jí)301病例9整理ppt3D

ASL臨床應(yīng)用--腫瘤分級(jí)

50歲，男性，腦干占位病變，平掃T2與T1加權(quán)像301病例10整理ppt3D

ASL臨床應(yīng)用--腫瘤分級(jí)CBF=109CBF=49DSC灌注3DASL11整理ppt

51歲，男性，右頂葉占位病變術(shù)后，T2WI與DWI3D

ASL臨床應(yīng)用--術(shù)后評(píng)估301病例12整理ppt術(shù)后增強(qiáng)3D

ASL臨床應(yīng)用--術(shù)后評(píng)估DSC灌注13整理pptCBF=85CBF=41DSC灌注3DASL3D

ASL臨床應(yīng)用--術(shù)后評(píng)估14整理ppt3D

ASL臨床應(yīng)用--梗死后再灌注治療前治療后49歲男性，右側(cè)肢體力弱301病例15整理ppt

3DASL顯示溶栓治療后過(guò)度灌注3D

ASL臨床應(yīng)用--梗死后再灌注16整理ppt3D

ASL臨床應(yīng)用--MELAS與腦梗死鑒別

MELAS腦梗死LouX,MaL,etal.DifferentialDiagnosisofMELASandIschemicStrokeusing3DPseudocontinuousArterialSpinLabeling.ISMRMScientificMeeting,Italy,2014301病例17整理ppt提綱18整理pptN=8healthyvolunteers(7M,1F,27-41Y)PCASL,BS,3DspiralFSE3Scanson2scanners,10-15daysapartPLD=2.5SPLD=1.5S1sttest(scanner1)2ndtest(scanner2)3rdtest(scanner1)100806040200100806040200PLD=1.5SPLD=2.5S100806040200PLD=1.5SPLD=2.5SSubject1Subject2Subject3100806040200PLD=1.5SPLD=2.5SSubject43D

ASL研究進(jìn)展--可重復(fù)性研究19整理pptWuB,LouX*,WuXH,MaL.Intra-andinter-scannerreliabilityandreproducibilityof3Dwhole-brainpseudo-continuousarterialspin-labelingMRperfusionon3T.JMagnResonImaging.2014;39(2):402-9.3D

ASL研究進(jìn)展--可重復(fù)性研究20整理pptHuangDD,WuB,ShiKN,MaLLouX*.ReliabilityofThree-dimensionalpseudo-continuousarterialspinlabellingMRimagingformeasuringvisualcortexperfusionontwo3Tscanners.PLOSONE.2013;8(11):e79471HuangDD,LouX*,MaL,etc.RSNA,2013,Oralpresentation3D

ASL研究進(jìn)展--可重復(fù)性研究21整理ppt3D

ASL研究進(jìn)展--標(biāo)記時(shí)間研究22整理ppt16.5651.0442.2943.123D

ASL研究進(jìn)展--標(biāo)記時(shí)間研究PLD=1.5SPLD=2.5S301病例23整理pptLouX,MaL.Can3DpCASLbeanotherpredictortoevaluatethecollateralPerfusioninPatientswithsevereintracranialarterialstenosis?ISMRMScientificMeeting,Italy,20143D

ASL研究進(jìn)展--側(cè)枝循環(huán)成像301病例24整理pptHernandezDa,etc.Pseudocontinuousarterialspinlabelingquantifiesrelativecerebralbloodflowinacutestroke.Stroke.2012;43:753–8.WangDJ,etc.Thevalueofarterialspin-labeledperfusionimaginginacuteischemicstroke:comparisonwithdynamicsusceptibilitycontrast-enhancedMRI.Stroke.2012;43:1018–24.BokkersRPH,etc.Whole-brainarterialspinlabelingperfusionMRIinpatientswithacutestroke.Stroke.2012;43:1290–4.3D

ASL研究進(jìn)展--ASL與DSC的比較有很好的一致性CBF的側(cè)值無(wú)明顯差異ASL

更有利于顯示治療后的過(guò)度灌注(luxuryperfusion)25整理pptMusiekES,etc.DirectcomparisonoffluorodeoxyglucosepositronemissiontomographyandarterialspinlabelingmagneticresonanceimaginginAlzheimer'sdisease.AlzheimersDement.2012;8:51-9.3D

ASL研究進(jìn)展--ASL與FDG的比較26整理ppt3D

ASL研究進(jìn)展--

在AD中的應(yīng)用MajaA.A.Binnewijzend,etc.CerebralBloodFlowMeasuredwith3DPseudocontinuousArterialSpin-labelingMRImaginginAlzheimerDiseaseandMildCognitiveImpairment:AMarkerforDiseaseSeverity.Radiology2013;267:221–230.70SubjectswithSubjectiveComplaints31PatientswithMCI71PatientswithAD27整理ppt腦發(fā)育過(guò)程中全腦CBF的變化腦發(fā)育過(guò)程中扣帶回和枕葉的變化3D

ASL研究進(jìn)展--在腦發(fā)育中的應(yīng)用28整理ppt小結(jié)ASL技術(shù)進(jìn)行腦灌注成像準(zhǔn)確無(wú)創(chuàng)在ASL技術(shù)中PCASL序列SNR高，SAR較