互聯(lián)網(wǎng)生物信息資源-課件

互聯(lián)網(wǎng)生物信息資源

BioinformaticsResourcesontheInternet1PPT課件互聯(lián)網(wǎng)生物信息資源

BioinformaticsResou1Halfdayontheweb,halfmonthinthelab.savesyou-AlanBleasby2PPT課件Halfdayontheweb,halfmonth2精品資料精品資料3你怎么稱呼老師？如果老師最后沒有總結(jié)一節(jié)課的重點(diǎn)的難點(diǎn)，你是否會認(rèn)為老師的教學(xué)方法需要改進(jìn)？你所經(jīng)歷的課堂，是講座式還是討論式？教師的教鞭“不怕太陽曬，也不怕那風(fēng)雨狂，只怕先生罵我笨，沒有學(xué)問無顏見爹娘……”“太陽當(dāng)空照，花兒對我笑，小鳥說早早早……”互聯(lián)網(wǎng)生物信息資源--ppt課件402022000

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AGAGGAAA2000年2月2日，北京大學(xué)燕北園300多位教師的家用計算機(jī)接入Internet；2001年2月12日，北京大學(xué)2000多個本科生宿舍的計算機(jī)接入Internet.BioMedXBioinformatics5PPT課件02022000

01011000

AGAGGAAA20005網(wǎng)絡(luò)時代的生命科學(xué)和生物技術(shù)產(chǎn)業(yè)討論會9-10Apr2001首屆中國生物信息學(xué)大會11-13Apr20016PPT課件網(wǎng)絡(luò)時代的生命科學(xué)和生物技術(shù)產(chǎn)業(yè)首屆中國生物信息學(xué)6PPT課6引自JPostlethwait&JHopson著TheNatureofLife，1989從基本粒子到生物圈7PPT課件引自JPostlethwait&JHopson著Th7引自NeilCampbell著Biology第4版，1996生物界病毒細(xì)菌8PPT課件引自NeilCampbell著Biology第4版，1998植物細(xì)胞動物細(xì)胞引自NeilCampbell著Biology第4版，19969PPT課件植物細(xì)胞動物細(xì)胞引自NeilCampbell著Biolog9引自NeilCampbell著Biology第4版，1996細(xì)胞分裂10PPT課件引自NeilCampbell著Biology第4版，19910人類23對染色體11PPT課件人類23對染色體11PPT課件11DNA-遺傳密碼的攜帶者12PPT課件DNA-遺傳密碼的攜帶者12PPT課件12引自NeilCampbell著Biology第4版，199613PPT課件引自NeilCampbell著Biology第4版，19913引自NeilCampbell著Biology第4版,1996胰島素蛋白酶蜘蛛毒素光合作用受體金屬硫蛋白14PPT課件引自NeilCampbell著Biology第4版,1991415PPT課件15PPT課件15Nature171,737-734(1953)(C)MacmillanPublishersLtd.MolecularstructureofNucleicAcidsWATSON,J.D.&CRICK,F.H.C.MedicalResearchCouncilUnitfortheStudyofMolecularStructureofBiologicalSystems,CavendishLaboratory,Cambridge.Figure1Thisfigureispurelydiagrammatic.Thetworibbonssymbolizethetwophophate-sugarchains,andthehorizonalrodsthepairsofbasesholdingthechainstogether.Theverticallinemarksthefibreaxis.AStructureforDeoxyriboseNucleicAcidWewishtosuggestastructureforthesaltofdeoxyribosenucleicacid(D.N.A.).Thisstructurehasnovelfeatureswhichareofconsiderablebiologicalinterest.16PPT課件Nature171,737-734(1953)(C)16“What’sHumanGenomeProject?”“OnebaseOnedollar!”-byataxidriver(andataxpayer)17PPT課件“What’sHumanGenomeProject?”17humanArabidopsis擬南芥ThermotogamaritimaEscherichiacoli大腸桿菌Buchnerasp.APSRickettsiaprowazekiiUreaplasmaurealyticumBacillussubtilisDrosophilamelanogasterThermoplasmaacidophilumPlasmodiumfalciparumHelicobacterpylorimouseCaenorhabitiselegansratBorreliaburgorferiBorreliaburgorferiAquifexaeolicusNeisseriameningitidisZ2491Mycobacteriumtuberculosis18PPT課件humanArabidopsisThermotogamar18圖片引自http://www.ri.bbsrc.ac.uk/arkdb/sites.html數(shù)據(jù)引自/GOLD/19PPT課件圖片引自http://www.ri.bbsrc.ac.uk/19Initialsequencingandanalysisofthehumangenome

[PDF]Nature409,860-921(2001),15February2001

InternationalHumanGenomeSequencingConsortiumWhiteheadInstituteforBiomedicalResearch,CenterforGenomeResearch:ERICS.LANDER1*,LAURENM.LINTON1,BRUCEBIRREN1*,CHADNUSBAUM1*,MICHAELC.ZODY1*,JENNIFERBALDWIN1,KERIDEVON1,KENDEWAR1,MICHAELDOYLE1,WILLIAMFITZHUGH1*,ROELFUNKE1,DIANEGAGE1,KATRINAHARRIS1,ANDREWHEAFORD1,JOHNHOWLAND1,LISAKANN1,JESSICALEHOCZKY1,ROSIELEVINE1,PAULMCEWAN1,KEVINMCKERNAN1,JAMESMELDRIM1,JILLP.MESIROV1,CHERMIRANDA1,WILLIAMMORRIS1,JEROMENAYLOR1,CHRISTINARAYMOND1,MARKROSETTI1,RALPHSANTOS1,ANDREWSHERIDAN1,CARRIESOUGNEZ1,NICOLESTANGE-THOMANN1,NIKOLASTOJANOVIC1,ARAVINDSUBRAMANIAN1&DUDLEYWYMAN1TheSangerCentre:JANEROGERS2,JOHNSULSTON2*,RACHAELAINSCOUGH2,STEPHANBECK2,DAVIDBENTLEY2,JOHNBURTON2,CHRISTOPHERCLEE2,NIGELCARTER2,ALANCOULSON2,REBECCADEADMAN2,PANOSDELOUKAS2,ANDREWDUNHAM2,IANDUNHAM2,RICHARDDURBIN2*,LISAFRENCH2,DARRENGRAFHAM2,SIMONGREGORY2,TIMHUBBARD2*,SEANHUMPHRAY2,ADRIENNEHUNT2,MATTHEWJONES2,CHRISTINELLOYD2,AMANDAMCMURRAY2,LUCYMATTHEWS2,SIMONMERCER2,SARAHMILNE2,JAMESC.MULLIKIN2,ANDREWMUNGALL2,ROBERTPLUMB2,MARKROSS2,RATNASHOWNKEEN2&SARAHSIMS2WashingtonUniversityGenomeSequencingCenterROBERTH.WATERSTON3*,RICHARDK.WILSON3,LADEANAW.HILLIER3,JOHND.MCPHERSON3,MARCOA.MARRA3,ELAINER.MARDIS3,LUCINDAA.FULTON3,ASIFT.CHINWALLA3,KYMBERLIEH.PEPIN3,WARRENR.GISH3,STEPHANIEL.CHISSOE3,MICHAELC.WENDL3,KIMD.DELEHAUNTY3,TRACIEL.MINER3,ANDREWDELEHAUNTY3,JASONB.KRAMER3,LISAL.COOK3,ROBERTS.FULTON3,DOUGLASL.JOHNSON3,PATRICKJ.MINX3&SANDRAW.CLIFTON3USDOEJointGenomeInstitute:TREVORHAWKINS4,ELBERTBRANSCOMB4,PAULPREDKI4,PAULRICHARDSON4,SARAHWENNING4,TOMSLEZAK4,NORMANDOGGETT4,JAN-FANGCHENG4,ANNEOLSEN4,SUSANLUCAS4,CHRISTOPHERELKIN4,EDWARDUBERBACHER4&MARVINFRAZIER4BaylorCollegeofMedicineHumanGenomeSequencingCenter:RICHARDA.GIBBS5*,DONNAM.MUZNY5,STEVENE.SCHERER5,JOHNB.BOUCK5,ERICAJ.SODERGREN5,KIMC.WORLEY5,CATHERINEM.RIVES5,JAMESH.GORRELL5,MICHAELL.METZKER5,SUSANL.NAYLOR6,RAJUS.KUCHERLAPATI7,DAVIDL.NELSON&GEORGEM.WEINSTOCK8RIKENGenomicSciencesCenter:YOSHIYUKISAKAKI9,ASAOFUJIYAMA9,MASAHIRAHATTORI9,TETSUSHIYADA9,ATSUSHITOYODA9,TAKEHIKOITOH9,CHIHARUKAWAGOE9,HIDEMIWATANABE9,YASUSHITOTOKI9&TODDTAYLOR9GenoscopeandCNRSUMR-8030:JEANWEISSENBACH10,ROLANDHEILIG10,WILLIAMSAURIN10,FRANCOISARTIGUENAVE10,PHILIPPEBROTTIER10,THOMASBRULS10,ERICPELLETIER10,CATHERINEROBERT10&PATRICKWINCKER10GTCSequencingCenter:DOUGLASR.SMITH11,LYNNDOUCETTE-STAMM11,MARCRUBENFIELD11,KEITHWEINSTOCK11,HONGMEILEE11&JOANNDUBOIS11DepartmentofGenomeAnalysis,InstituteofMolecularBiotechnology:ANDRéROSENTHAL12,MATTHIASPLATZER12,GERALDNYAKATURA12,STEFANTAUDIEN12&ANDREASRUMP12BeijingGenomicsInstitute/HumanGenomeCenter:HUANMINGYANG13,JUNYU13,JIANWANG13,GUYANGHUANG14&JUNGU15MultimegabaseSequencingCenter,TheInstituteforSystemsBiology:LEROYHOOD16,LEEROWEN16,ANUPMADAN16&SHIZENQIN16StanfordGenomeTechnologyCenter:RONALDW.DAVIS17,NANCYA.FEDERSPIEL17,A.PIAABOLA17&MICHAELJ.PROCTOR17StanfordHumanGenomeCenter:RICHARDM.MYERS18,JEREMYSCHMUTZ18,MARKDICKSON18,JANEGRIMWOOD18&DAVIDR.COX18UniversityofWashingtonGenomeCenter:MAYNARDV.OLSON19,RAJINDERKAUL19&CHRISTOPHERRAYMOND19DepartmentofMolecularBiology,KeioUniversitySchoolofMedicine:NOBUYOSHISHIMIZU20,KAZUHIKOKAWASAKI20&SHINSEIMINOSHIMA20UniversityofTexasSouthwesternMedicalCenteratDallas:GLENA.EVANS21?,MARIAATHANASIOU21&ROGERSCHULTZ21UniversityofOklahoma'sAdvancedCenterforGenomeTechnology:BRUCEA.ROE22,FENGCHEN22&HUAQINPAN22MaxPlanckInstituteforMolecularGenetics:JULIANERAMSER23,HANSLEHRACH23&RICHARDREINHARDT23ColdSpringHarborLaboratory,LitaAnnenbergHazenGenomeCenter:W.RICHARDMCCOMBIE24,MELISSADELABASTIDE24&NEILAYDEDHIA24GBF—GermanResearchCentreforBiotechnology:HELMUTBL?CKER25,KLAUSHORNISCHER25&GABRIELENORDSIEK2520PPT課件Initialsequencingandanalysi20

TheSequenceoftheHumanGenome

[PDF]J.CraigVenter,MarkD.Adams,EugeneW.Myers,PeterW.Li,RichardJ.Mural,GrangerG.Sutton,HamiltonO.Smith,MarkYandell,CherylA.Evans,RobertA.Holt,JeannineD.Gocayne,PeterAmanatides,RichardM.Ballew,DanielH.Huson,JenniferRussoWortman,QingZhang,ChinnappaD.Kodira,XiangqunH.Zheng,LinChen,MarianSkupski,GangadharanSubramanian,PaulD.Thomas,JinghuiZhang,GeorgeL.GaborMiklos,CatherineNelson,SamuelBroder,AndrewG.Clark,4JoeNadeau,VictorA.McKusick,NortonZinder,ArnoldJ.Levine,RichardJ.Roberts,8MelSimon,CarolynSlayman,MichaelHunkapiller,RandallBolanos,ArthurDelcher,IanDew,DanielFasulo,MichaelFlanigan,LilianaFlorea,AaronHalpern,SridharHannenhalli,SaulKravitz,SamuelLevy,ClarkMobarry,KnutReinert,KarinRemington,JaneAbu-Threideh,EllenBeasley,KendraBiddick,VivienBonazzi,RhondaBrandon,MicheleCargill,Ishwarhandramouliswaran,RosaneCharlab,KabirChaturvedi,ZuomingDeng,ValentinaDiFrancesco,PatrickDunn,KarenEilbeck,CarlosEvangelista,AndreiE.Gabrielian,WeiniuGan,WangmaoGe,FangchengGong,

ZhipingGu,PingGuan,ThomasJ.Heiman,MaureenE.Higgins,Rui-RuJi,ZhaoxiKe,KarenA.Ketchum,ZhongwuLai,

YidingLei,ZhenyaLi,JiayinLi,YongLiang,XiaoyingLin,FuLu,GennadyV.Merkulov,NataliaMilshina,HelenM.Moore,AshwinikumarKNaik,VaibhavA.Narayan,BeenaNeelam,DeborahNusskern,DouglasB.Rusch,StevenSalzberg,WeiShao,BixiongShue,JingtaoSun,ZhenYuanWang,AihuiWang,XinWang,JianWang,Ming-HuiWei,RonWides,ChunlinXiao,ChunhuaYan,AlisonYao,JaneYe,MingZhan,WeiqingZhang,HongyuZhang,QiZhao,LianshengZheng,FeiZhong,WenyanZhong,ShiaopingC.Zhu,ShayingZhao,DennisGilbert,SuzannaBaumhueter,GeneSpier,ChristineCarter,AnibalCravchik,TrevorWoodage,FerozeAli,HuijinAn,AderonkeAwe,DanitaBaldwin,HollyBaden,MaryBarnstead,IanBarrow,Kareneeson,DanaBusam,AmyCarver,AngelaCenter,MingLaiCheng,LizCurry,SteveDanaher,LionelDavenport,RaymondDesilets,SusanneDietz,KristinaDodson,LisaDoup,StevenFerriera,NehaGarg,AndresGluecksmann,BritHart,JasonHaynes,CharlesHaynes,CherylHeiner,SuzanneHladun,DamonHostin,JarrettHouck,TimothyHowland,ChinyereIbegwam,JefferyJohnson,FrancisKalush,LesleyKline,ShashiKoduru,AmyLove,FeleciaMann,DavidMay,StevenMcCawley,TinaMcIntosh,IvyMcMullen,MeeMoy,LindaMoy,BrianMurphy,KeithNelson,CynthiaPfannkoch,EricPratts,VinitaPuri,HinaQureshi,MatthewReardon,RobertRodriguez,Yu-HuiRogers,DeannaRomblad,BobRuhfel,RichardScott,CynthiaSitter,MichelleSmallwood,rinStewart,ReneeStrong,EllenSuh,ReginaldThomas,NiNiTint,SukyeeTse,ClaireVech,GaryWang,JeremyWetter,SheritaWilliams,MonicaWilliams,SandraWindsor,EmilyWinn-Deen,KeriellenWolfe,JayshreeZaveri,KarenaZaveri,JosepF.Abril,4RodericGuigó,4MichaelJ.Campbell,KimmenV.Sjolander,BrianKarlak,AnishKejariwal,HuaiyuMi,BettyLazareva,ThomasHatton,ApurvaNarechania,KarenDiemer,AnushyaMuruganujan,NanGuo,ShinjiSato,VineetBafna,SorinIstrail,RossLippert,RussellSchwartz,BrianWalenz,ShibuYooseph,DavidAllen,AnandBasu,JamesBaxendale,LouisBlick,MarceloCaminha,JohnCarnes-Stine,ParrisCaulk,Yen-HuiChiang,MyCoyne,CarlDahlke,AnneDeslattesMays,MariaDombroski,MichaelDonnelly,DaleEly,ShivaEsparham,CarlFosler,HaroldGire,StephenGlanowski,KennethGlasser,AnnaGlodek,MarkGorokhov,KenGraham,BarryGropman,MichaelHarris,JeremyHeil,ScottHenderson,JeffreyHoover,DonaldJennings,CatherineJordan,JamesJordan,JohnKasha,LeonidKagan,CherylKraft,AlexanderLevitsky,MarkLewis,XiangjunLiu,JohnLopez,DanielMa,WilliamMajoros,JoeMcDaniel,SeanMurphy,MatthewNewman,TrungNguyen,NgocNguyen,MarcNodell,SuePan,JimPeck,MarshallPeterson,WilliamRowe,RobertSanders,JohnScott,MichaelSimpson,ThomasSmith,ArlanSprague,TimothyStockwell,RussellTurner,EliVenter,MeiWang,MeiyuanWen,DavidWu,MitchellWu,AshleyXia,AliZandieh,XiaohongZhu

21PPT課件TheSequenceoftheHumanGen2122PPT課件22PPT課件22IDPSPPF1standard;RNA;PLN;1523BP.ACY12618;SVY12618.1DT30-JUN-1997(Rel.52,Created)DT02-FEB-1999(Rel.58,Lastupdated,Version4)DEPisumsativummRNAforPPF-1proteinKWppf-1gene;PPF-1protein.OSPisumsativum(pea)OCEukaryota;Viridiplantae;Streptophyta;Embryophyta;Tracheophyta;OCeuphyllophytes;Spermatophyta;Magnoliophyta;eudicotyledons;OCcoreeudicots;Rosidae;eurosidsI;Fabales;Fabaceae;Papilionoideae;OCPisum.RN[1]RAZhuY.,ZhangY.,LuoJ.,DaviesP.J.,HoD.T.H.;RT"PPF-1,apost-floral-specificgeneexpressedinshort-day-grownG2pea,RTmaybeimportantforitsnever-senescingphenotype";RLGene208:1-6(1998).RN[3]RP1-1523RAZhangY.;RT;RLSubmitted(02-FEB-1999)totheEMBL/GenBank/DDBJdatabases.RLY.Zhang,PekingUniversity,Box28,CollegeofLifeSciences,Beijing,RL100871,PRCDRDemeter;Y12618;Y12618.DRMENDEL;14275;Pissa;2332;14275.DRSPTREMBL;O04699;O04699.FHKeyLocation/QualifiersFHFTsource1..1523FT/db_xref="taxon:3888"FT/organism="Pisumsativum"FT/strain="G2"FT/dev_stage="pre-floralseedlings"FT/tissue_type="apicalbud"FT/clone_lib="lambdaZAPII"FTCDS48..1376FT/db_xref="SPTREMBL:O04699"FT/gene="ppf-1"FT/product="PPF-1protein"FT/protein_id="CAA73179.1"FT/translation="MAKTLISSPSFLGTPLPSLHRTFSPNRTRLFTKVQFSFHQLPPIQFTSVSHSVDLSGIFARAEGLLYTLADATVAADAAASTDVAAQKNGGWFGFISDGMEFVLKVFTLKDGLSSVHVPYSYGFAIILLTVIVKAATLPLTKQQVESTLAMQNLQPKIKAIQERYAGFTNQERIQLETSRLYTQAGVNPLAGCLPTLATIPVWIGLYQALSNVANEGLLTEGFLWIPSFTLGGPTSIAARQSGSGISWLFPFVDGHPLLGWYDTAAYLVLPVLLIVSQYVSMEIMKPPQFTTNDPNQKNTLLIFKFLPLMIGYFSLSVPSGLTIYWFTNNVLSTAQQVWLRKLGGAKPAVFTNENAGGIITAGQAKRSASKPEKGGERFRQLKEEEKKKKLIKALPVEEVQPLASASASNDFTGSDVENNKEQEVTEESNTSKVSQEVQSFSRERRSKRSKRKPVA"SQSequence1523BP;421A;325C;311G;466T;0other;ctcaagccttcaagcctgaagcgtctcgtacacaaaccttctcatccatggcgaagacac60tgatttcttctccatcattcctcggtactccacttccttcacttcaccgtactttctccc120ctaatcgcaccaggcttttcaccaaagttcaattcagtttccaccaacttcctccgattc180......ggaccacatacatttgtttgtagtttatagtaagttttgtatatgtcaaacagtttgtat1440catttttgggttgacaattttattgaacatgttatttaatcatgcaaaatatcttttgtt1500tcatttaagttccacatgttagc 1523//23PPT課件IDPSPPF1standard;RNA;2324PPT課件24PPT課件2425PPT課件25PPT課件2526PPT課件26PPT課件26SWISS-PROT:TXH1_SELHU(P56676)HUWENTOXIN-I(HWTX-I).Chinesebirdspider).DISULFID2-179-2216-2927PPT課件SWISS-PROT:TXH1_SELHU(P5667627編號：U00096名稱：Escherichiacoli菌株：K-12MG1655基因數(shù)：4293個堿基數(shù)：4639221bp28PPT課件編號：U0009628PPT課件28生物信息的開發(fā)和應(yīng)用以核酸蛋白質(zhì)等生物大分子為主要研究對象以信息、數(shù)理、計算機(jī)科學(xué)為主要研究手段以計算機(jī)網(wǎng)絡(luò)為主要研究環(huán)境以計算機(jī)軟件為主要研究工具對序列數(shù)據(jù)進(jìn)行存儲、管理、注釋、加工對各種數(shù)據(jù)庫進(jìn)行查詢、搜索、比較、分析構(gòu)建各種類型的專用數(shù)據(jù)庫信息系統(tǒng)研究開發(fā)面向生物學(xué)家的新一代計算機(jī)軟件29PPT課件生物信息的開發(fā)和應(yīng)用以核酸蛋白質(zhì)等生物大分子為主要研究對象229生物信息學(xué)研究利用數(shù)理統(tǒng)計、模式識別、動態(tài)規(guī)劃、密碼解讀、語意解析、信令傳遞、神經(jīng)網(wǎng)絡(luò)、遺傳算法以及隱馬氏模型等各種方法對序列、結(jié)構(gòu)數(shù)據(jù)進(jìn)行定性和定量分析，從中獲取基因編碼、基因調(diào)控、序列-結(jié)構(gòu)-功能關(guān)系等理性知識闡明細(xì)胞、器官和個體的發(fā)生、發(fā)育、病變、衰亡的基本規(guī)律和時空聯(lián)系探索生命起源、生物進(jìn)化、生命本質(zhì)等重大理論問題，最終建立“生物學(xué)周期表”30PPT課件生物信息學(xué)研究利用數(shù)理統(tǒng)計、模式識別、動態(tài)規(guī)劃、密碼解讀、語30生物信息學(xué)–研究方向基因組序列裝配基因識別基因功能預(yù)報基因多態(tài)性分析基因進(jìn)化mRNA結(jié)構(gòu)預(yù)測基因芯片設(shè)計基因芯片數(shù)據(jù)分析疾病相關(guān)基因分析蛋白質(zhì)序列分析蛋白質(zhì)家族分類蛋白質(zhì)結(jié)構(gòu)預(yù)測蛋白質(zhì)折疊研究代謝途徑分析轉(zhuǎn)錄調(diào)控機(jī)制蛋白質(zhì)芯片設(shè)計蛋白質(zhì)芯片數(shù)據(jù)分析藥物設(shè)計31PPT課件生物信息學(xué)–研究方向基因組序列裝配蛋白質(zhì)序列分析31PP31引自NeilCampbell著Biology第4版,996生物進(jìn)化32PPT課件引自NeilCampbell著Biology第4版,99632“Daday,whereI’mfrom?”“Mum,whyI’mdifferentfromSally?”33PPT課件“Daday,whereI’mfrom?”33PPT課33

Discoverycannotbewaited!

世界上每分鐘有10個兒童死于營養(yǎng)不良每小時有11個美國人死于用藥不當(dāng)愛茲病毒每天在一個病人身上擴(kuò)增一億倍34PPT課件Discoverycannotbewaited!34實(shí)驗生物學(xué)計算生物學(xué)理論生物學(xué)35PPT課件實(shí)驗計算理論35PPT課件35國際著名生物信息中心

BioinformaticsCentresNCBI NationalCenterforBiotechnologyInformation(US)

EBI EuropeanBioinformaticsInstitute(EU)

HGMP HumanGenomeMappingProjectResourceCentre(UK)ExPASyExpertofProteinAnalysisSystem(Switzerland)CMBI CentreofMolecularandBiomolecule(TheNetherlands)ANGIS NationalGenomeInformationService(Australia)NIG NationalInstituteofGenetics(Japan)BIC NationalBioinformaticsCentre(Singapore)36PPT課件國際著名生物信息中心

BioinformaticsCent36歐洲分子生物學(xué)網(wǎng)絡(luò)組織

(EMBnet)

EuropeanMolecularBiologyNetworkEMBnet為國際著名生物信息學(xué)組織，為世界各國提供生物信息資源，并合作進(jìn)行生物信息的研究、開發(fā)、應(yīng)用和人才培訓(xùn)。37PPT課件歐洲分子生物學(xué)網(wǎng)絡(luò)組織(EMBnet)

European37EMBnet國家節(jié)點(diǎn)歐洲:

奧地利、比利時、丹麥、法國、芬蘭、德國、希臘匈牙利、愛爾蘭、以色列、意大利、挪威、波蘭、葡萄牙、斯洛伐克、西班牙、瑞典、瑞士、荷蘭、土耳其、英國亞洲:

中國、印度澳洲:

澳大利亞北美洲:

加拿大非洲：南非南美洲:

阿根廷、古巴、智利、墨西哥38PPT課件EMBnet國家節(jié)點(diǎn)歐洲:38PPT課件38亞太生物信息學(xué)網(wǎng)絡(luò)組織中國節(jié)點(diǎn)39PPT課件亞太生物信息學(xué)網(wǎng)絡(luò)組織中國節(jié)點(diǎn)39PPT課件39生物技術(shù)和信息技術(shù)是21世紀(jì)的兩大經(jīng)濟(jì)發(fā)展支柱，生物信息學(xué)是生命科學(xué)和信息科學(xué)的結(jié)合點(diǎn)，是當(dāng)今自然科學(xué)新的前沿領(lǐng)域。生物信息資源建設(shè)是生物信息研究開發(fā)的基礎(chǔ)。1996年，北京大學(xué)加入歐洲分子生物學(xué)網(wǎng)絡(luò)組織，成為該組織的中國國家節(jié)點(diǎn)，并成立生物信息中心，為生物、醫(yī)學(xué)、制藥、農(nóng)業(yè)、環(huán)境等領(lǐng)域的研究開發(fā)提供生物信息資源服務(wù)，并開展二次數(shù)據(jù)庫構(gòu)建、軟件集成、基因組分析等研究。歐洲分子生物學(xué)網(wǎng)絡(luò)組織中國國家節(jié)點(diǎn)NationalNodeEuropeanMolecularBiologyNetwork北京大學(xué)生物信息中心CentreofBioinformaticsPekingUniversity40PPT課件生物技術(shù)和信息技術(shù)是21世紀(jì)的兩大經(jīng)濟(jì)發(fā)展支柱，生物信息學(xué)是4041PPT課件41PPT課件4142PPT課件42PPT課件42數(shù)據(jù)庫查詢數(shù)據(jù)庫搜索文件下載網(wǎng)絡(luò)教程網(wǎng)絡(luò)新聞序列分析序列裝配分子模型結(jié)構(gòu)分析藥物設(shè)計43PPT課件數(shù)據(jù)庫查詢43PPT課件432000年CBI主服務(wù)器頁面訪問量44PPT課件2000年CBI主服務(wù)器頁面訪問量44PPT課件44安裝了70多個數(shù)據(jù)庫，提供200多種軟件下載建立了14個國外著名生物信息中心鏡象提供了數(shù)據(jù)庫和文獻(xiàn)查詢、搜索構(gòu)建了中華民族基因多樣性等專用數(shù)據(jù)庫集成和開發(fā)了基于Web的生物信息軟件工具開展了分子模擬、序列分析等應(yīng)用研究舉辦了國際國內(nèi)培訓(xùn)班、講習(xí)班、討論會開設(shè)了生物信息學(xué)概論研究生課程45PPT課件安裝了70多個數(shù)據(jù)庫，提供200多種軟件下載45PPT課件4546PPT課件46PPT課件4647PPT課件47PPT課件47中華民族基因多樣性數(shù)據(jù)庫轉(zhuǎn)錄因子細(xì)胞特異性數(shù)據(jù)庫Cytomer蛋白質(zhì)結(jié)構(gòu)域數(shù)據(jù)庫Domain蛋白質(zhì)回環(huán)數(shù)據(jù)庫Loop水稻矮縮病毒數(shù)據(jù)庫RDV二硫鍵信息數(shù)據(jù)庫Bridge構(gòu)建二次數(shù)據(jù)庫48PPT課件中華民族基因多樣性數(shù)據(jù)庫構(gòu)建二次數(shù)據(jù)庫48PPT課件48中華民族基因多態(tài)性數(shù)據(jù)庫49PPT課件中華民族基因多態(tài)性數(shù)據(jù)庫49PPT課件49水稻矮縮病毒基因組數(shù)據(jù)庫50PPT課件水稻矮縮病毒基因組數(shù)據(jù)庫50PPT課件50轉(zhuǎn)錄因子細(xì)胞特異表達(dá)數(shù)據(jù)庫51PPT課件轉(zhuǎn)錄因子細(xì)胞特異表達(dá)數(shù)據(jù)庫51PPT課件51蛋白質(zhì)回環(huán)數(shù)據(jù)庫52PPT課件蛋白質(zhì)回環(huán)數(shù)據(jù)庫52PPT課件52蛋白質(zhì)二硫鍵數(shù)據(jù)庫廖黔寧，羅靜初，周培愛，顧孝誠，梁宋平，虎紋捕鳥蛛毒素-I突變體的設(shè)計、合成和活性鑒定，中國生物化學(xué)和分子生物學(xué)學(xué)報,5(5):756-761,1999年。SYLu,PCDeng,XCLiu,JCLuo,RSHan,XCGu，SPLiang,XCWang,FLi,VLozanov,APatthyandSPongor,SolutionstructureoftheMajora-amylaseinhibitorofthecropplantamaranth，J.Biol.Chem.274(29):20473-20478,1999.53PPT課件蛋白質(zhì)二硫鍵數(shù)據(jù)庫廖黔寧，羅靜初，周培愛，顧孝誠，梁宋平，虎5354PPT課件54PPT課件5455PPT課件55PPT課件5556PPT課件56PPT課件56擬南芥突變體庫數(shù)據(jù)庫—北大耶魯合作項目57PPT課件擬南芥突變體庫數(shù)據(jù)庫—北大耶魯合作項目57PPT課件57ComputerAidedVaccineDesignSystemDatabaseArticlesLabWorkAlgorithm(ANN),AnalysisProgram,AdjustProgram…DataFlowRight/Wrong?Right/Wrong?AnswerAnswer58PPT課件ComputerAidedVaccineDesign58生物信息學(xué)應(yīng)用研究–分子模型LiuY,LuoJ,XuC,RenF,PengC,WuG,ZhaoJ,Purification,characterization,andmolecularcloningofthegeneofaseed-specificantimicrobialproteinfrompokeweed.PlantPhysiol

122(4):1015-24,2000.59PPT課件生物信息學(xué)應(yīng)用研究–分子模型LiuY,LuoJ,59生物信息學(xué)應(yīng)用研究–序列分析ZhuY,Zhang,Y,LuoJ,Davie