先睹為快！2024 AACR年會：PCF空間單細(xì)胞蛋白組應(yīng)用案例集錦

先睹為快！2024AACR年會：PCF空間單細(xì)胞蛋白組應(yīng)用案例集錦2024年美國癌癥研究協(xié)會（AACR）年會于美國時間4月5日-10日在美國加州圣地亞哥舉行。Cancerresearch雜志發(fā)表了年會提交的摘要，我們從中檢索了新一代空間組學(xué)技術(shù)Phenocycler-Fusion（PCF）空間單細(xì)胞蛋白組技術(shù)的應(yīng)用案例。從檢索結(jié)果可以發(fā)現(xiàn)PCF空間單細(xì)胞蛋白組技術(shù)已經(jīng)被廣泛的應(yīng)用到多種類型的腫瘤研究中，并且通過聯(lián)合其他空間組學(xué)研究人員深度解析了腫瘤微環(huán)境的異質(zhì)性和對不同治療策略響應(yīng)的空間機(jī)制。我們整理了部分PCF空間單細(xì)胞蛋白組的應(yīng)用案例，希望能為國內(nèi)研究人員提供一定的信息參考。題目：Deepspatialimmunophenotypingoflymphoidaggregatesinpancreaticcancerusingmulti-omicintegrationofultrahigh-plexproteomicsandtranscriptomics研究機(jī)構(gòu)：MDAndersonCancerCenter類型：胰腺癌PCF抗體數(shù)量：96-plex其他平臺：CosMxSMI鏈接：/cancerres/article/84/6_Supplement/3988/740632/Abstract-3988-Deep-spatial-immunophenotyping-of?searchresult=1題目：Multi-omicspatialanalysisofthetumormicroenvironmentingliomas研究機(jī)構(gòu)：ThePrestonRobertTischBrainTumorCenteratDuke類型：神經(jīng)膠質(zhì)瘤PCF抗體數(shù)量：>50-plex其他平臺：Xenium鏈接：/cancerres/article/84/6_Supplement/5496/741788/Abstract-5496-Multi-omic-spatial-analysis-of-the?searchresult=1題目：Spatialprofilingofpediatricrhabdomyosarcomatoelucidatetheirimmunosuppressivetumormicroenvironment研究機(jī)構(gòu)：UniversityofQueensland類型：兒童橫紋肌肉瘤PCF抗體數(shù)量：51-plex其他平臺：GeoMxDSP鏈接：/cancerres/article/84/6_Supplement/73/737520/Abstract-73-Spatial-profiling-of-pediatric?searchresult=1題目：Dissectingtumor-immuneinteractioninresponseandresistancetoimmunecheckpointblockadeinmetastaticmelanoma研究機(jī)構(gòu)：Dana-FarberCancerInstitute類型：黑色素瘤PCF抗體數(shù)量：NA其他平臺：MERFISH鏈接：/cancerres/article/84/6_Supplement/2486/740207/Abstract-2486-Dissecting-tumor-immune-interaction?searchresult=1題目：Decipheringtherolesofgermlinepredispositionvariantsandsomaticmutationsonbreastcancercellsandthetumormicroenvironment研究機(jī)構(gòu)：WashingtonUniversityinSt.Louis類型：乳腺癌PCF抗體數(shù)量：NA其他平臺：sc/snRNA-seq、snATAC-seq鏈接：/cancerres/article/84/6_Supplement/1773/735532/Abstract-1773-Deciphering-the-roles-of-germline?searchresult=1題目：Spatial-resolvedsingle-cellanalysisofthetumormicroenvironmentinAlaskaNativecolorectalcancerpatients研究機(jī)構(gòu)：FredHutchinsonCancerCenter類型：結(jié)直腸癌PCF抗體數(shù)量：40-plex鏈接：/cancerres/article/84/6_Supplement/3423/735764/Abstract-3423-Spatial-resolved-single-cell?searchresult=1題目：SpatiallyresolvedcellprofilingunveilstumormetabolicstatesassociatedwithimmunotherapyresponseinNSCLC研究機(jī)構(gòu)：UniversityofQueensland類型：非小細(xì)胞肺癌PCF抗體數(shù)量：45-plex鏈接：/cancerres/article/84/6_Supplement/1158/737448/Abstract-1158-Spatially-resolved-cell-profiling?searchresult=1題目：Single-cellspatiallandscapeofthemutation-specifichumanlungtumorimmunemicroenvironment研究機(jī)構(gòu)：JustusLiebigUniversity類型：肺癌PCF抗體數(shù)量：42-plex鏈接：/cancerres/article/84/6_Supplement/5508/738387/Abstract-5508-Single-cell-spatial-landscape-of-the?searchresult=1題目：High-resolutionspatialatlasrevealsinsightintospatiallandscapeoflungcancerandchroniclungdiseases研究機(jī)構(gòu)：JustusLiebigUniversity類型：肺癌PCF抗體數(shù)量：45-plex鏈接：/cancerres/article/84/6_Supplement/5507/738388/Abstract-5507-High-resolution-spatial-atlas?searchresult=1題目：Comparativespatialanalysesofthetumorimmunelandscapeindifferentmousemodelsofglioblastoma研究機(jī)構(gòu)：TheUniversityofMelbourne類型：膠質(zhì)母細(xì)胞瘤（小鼠）PCF抗體數(shù)量：>40-plex鏈接：/cancerres/article/84/6_Supplement/3763/738464/Abstract-3763-Comparative-spatial-analyses-of-the?searchresult=1題目：Aspatio-temporalapproachtomappingthedynamicsofcutaneoussquamouscellcarcinomaprogressionandimmunotherapyresponse:AjourneythroughTiME研究機(jī)構(gòu)：UniversityofQueensland類型：皮膚鱗狀細(xì)胞癌PCF抗體數(shù)量：>50-plex鏈接：/cancerres/article/84/6_Supplement/6872/738111/Abstract-6872-A-spatio-temporal-approach-to?searchresult=1題目：Overlappinganddistinctmechanismsofeffectiveneoantigencancervaccinesandimmunecheckpointtherapy研究機(jī)構(gòu)：MDAndersonCancerCenter類型：黑色素瘤（小鼠）PCF抗體數(shù)量：46-plex鏈接：/cancerres/article/84/6_Supplement/6738/736385/Abstract-6738-Overlapping-and-distinct-mechanisms?searchresult=1題目：Evolutionofthespatialmyeloid-lymphoidengagementinglioblastomaundertemozolomidetreatment研究機(jī)構(gòu)：MDAndersonCancerCenter類型：膠質(zhì)母細(xì)胞瘤PCF抗體數(shù)量：NA鏈接：/cancerres/article/84/6_Supplement/6171/736478/Abstract-6171-Evolution-of-the-spatial-myeloid?searchresult=1PhenoCycler-Fusion單細(xì)胞原位空間蛋白組學(xué)優(yōu)勢華盈生物PhenoCycler-Fusion單細(xì)胞原位空間蛋白組學(xué)技術(shù)資格證書華盈生物是美國AkoyaBioscience公司的PhenoCycler-Fusion空間單細(xì)胞蛋白組學(xué)技術(shù)認(rèn)證服務(wù)商，已經(jīng)被納入了該技術(shù)的全球CRO服務(wù)提供者體系。借助全球領(lǐng)先的PhenoCycler-Fusion空間單細(xì)胞蛋白組學(xué)技術(shù)平臺的建立，華盈生物將為中國客戶提供更具精準(zhǔn)醫(yī)學(xué)特色的服務(wù)與合作，推動中國團(tuán)隊在空間生物學(xué)領(lǐng)域的研究水平，加快構(gòu)建符合中國人群的精準(zhǔn)醫(yī)學(xué)模式。相關(guān)閱讀單細(xì)胞測序之后再怎么做？這篇文章告訴你答案Immunity(IF=32.4)|空間多組學(xué)聯(lián)合揭示免疫檢查點(diǎn)聯(lián)合療法響應(yīng)機(jī)制真實(shí)數(shù)據(jù)！一張切片實(shí)現(xiàn)101種蛋白的超多重空間單細(xì)胞原位成像4）炎癥性腸病開啟新的研究模式：從單細(xì)胞到空間原位分析5）CancerResearc