N-Desmethyl-Apalutamide-15N-d4-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEN-Desmethyl-Apalutamide-15N,d4Cat.No.:HY-135331S分?式:C??H?D?F?N???NO?S分?量:468.43作?靶點:Isotope-LabeledCompounds;AndrogenReceptor;CytochromeP450作?通路:Others;VitaminDRelated/NuclearReceptor;MetabolicEnzyme/Protease儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性N-Desmethyl-Apalutamide-15N,d415N和氚代標(biāo)記的N-Desmethyl-Apalutamide(HY-135331)。N-DesmethylApalutamideApalutamide的活性代謝產(chǎn)物，?種低活性的雄激素受體拮抗劑，其作??是Apalutamide活性的三分之?。N-DesmethylApalutamide的形成主由CYP2C8和CYP3A4介導(dǎo)。N-DesmethylApalutamide中等?強的CYP3A4和CYP2B6誘導(dǎo)劑，并具有優(yōu)異的?漿蛋?結(jié)合濃度。REFERENCES[1].Pérez-RuixoC,etal.PopulationPharmacokineticsofApalutamideanditsActiveMetaboliteN-Desmethyl-ApalutamideinHealthyandCastration-ResistantProstateCancerSubjects.ClinPharmacokinet.2019Aug20.[2].SmithMR,etal.Phase2StudyoftheSafetyandAntitumorActivityofApalutamide(ARN-509),aPotentAndrogenReceptorAntagonist,intheHigh-riskNonmetastaticCastration-resistantProstateCancerCohort.EurUrol.2016May6.pii:S0302-2838(16)30133[3].MayMB,etal.Apalutamide:Anewagentinthemanagementofprostatecancer.JOncolPharmPract.2019Dec;25(8):1968-1978.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax:021