免疫球蛋白特性王利沙Immunoglobulinproperties講解

免疫球蛋白特性主講老師：王利沙ImmunoglobulinpropertiesWeifangNursingVocationalCollege濰坊護(hù)理職業(yè)學(xué)院根據(jù)重鏈C區(qū)結(jié)構(gòu)的差別，將Ig分為五類，即IgG、IgA、IgM、IgD、IgE。AccordingtothestructuredifferenceofheavychainCregion,Igcanbedividedintofivecategories,namelyIgG,IgA,IgM,IgDandIgE.免疫球蛋白Immunoglobulin各類免疫球蛋白的特性Characteristicsofvariousimmunoglobulins

半衰期長(zhǎng)，約23天Thehalf-lifeislong,about23days.

機(jī)體再次免疫應(yīng)答的主要抗體

Themainantibodyofthebody'sre-immuneresponse.IgG

單體形式，含量高M(jìn)onomerform,highcontent

具有抗菌、抗病毒、抗毒素作用

Ithasantibacterial,antiviralandantitoxineffects.

IgG是唯一能通過胎盤的抗體

IgGistheonlyantibodythatcancrosstheplacenta.IgM機(jī)體感染后在血清中最早出現(xiàn)的抗體，臍帶血中IgM升高提示胎兒有宮內(nèi)感染；Thefirstantibodyappearedintheserumafterinfection,andtheincreaseofIgMinumbilicalcordbloodindicatedintrauterineinfectionofthefetus.個(gè)體發(fā)育中最早合成和分泌的抗體；Theearliestsynthesizedandsecretedantibodyinindividualdevelopment.半衰期短，約5天。Thehalf-lifeisshort,about5days.五聚體；

Pentamer分子量最大的免疫球蛋白；Thehighestmolecularweightimmunoglobulin.各類免疫球蛋白的特性Characteristicsofvariousimmunoglobulins分為血清型和分泌型（sIgA）兩種Twotypes:serotypeandsecretorytype(sIgA)血清型為單體，分泌型為二聚體Theserumtypeismonomerandthesecretiontypeisdimer.機(jī)體局部黏膜抗感染的重要因素；Theimportantfactoroflocalmucosalanti-infection.初乳中含有sIgA，故提倡母乳喂養(yǎng)；ColostrumcontainssIgA,sobreastfeedingisrecommended.IgA

各類免疫球蛋白的特性Characteristicsofvariousimmunoglobulins單體形式Monomericform.各類免疫球蛋白的特性CharacteristicsofvariousimmunoglobulinsIgD含量極低，為B細(xì)胞膜上的受體Extremelylowcontent,itisareceptorontheBcellmembrane.半衰期短，僅為3天Ithasashorthalf-lifeofonly3days.血清IgD功能尚未清楚。ThefunctionofserumIgDisunclear.血清中含量最少

Theleastamountwasfoundinserum.過敏性疾病或寄生蟲感染時(shí)，特異性IgE含量顯著增高。

Inallergicdiseasesorparasiticinfections,thespecificIgE

contentissignificantlyincreased.各類免疫球蛋白的特性Characteristicsofvariousimmunogl