Ocifisertib-hydrochloride-CFI-400945-hydrochloride-生命科學試劑-MCE-6463

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEOcifisertibhydrochlorideCat.No.:HY-12300ACASNo.:1338799-83-9Synonyms:CFI-400945hydrochloride分?式:C??H??ClN?O?分?量:571.11作?靶點:Polo-likeKinase(PLK);Apoptosis作?通路:CellCycle/DNADamage;Apoptosis儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性O(shè)cifisertibhydrochloride(CFI-400945hydrochloride)Ocifisertib(HY-12300)的鹽酸鹽形式。Ocifisertibhydrochloride?服有效的PLK4抑制劑，Ki和IC50分別為0.26nM和2.8nM。Ocifisertibhydrochloride可抑制多種癌細胞的?長，在G2/M期阻滯細胞周期，并誘導細胞凋亡(apoptosis)。Ocifisertibhydrochloride在??模型中表現(xiàn)出抗腫瘤活性。IC50&TargetPLK4TRKATRKBTIE2/TEK2.8nM(IC50)6nM(IC50)9nM(IC50)22nM(IC50)AURKB/INCENPAURKA98nM(IC50)140nM(IC50)戶使?本產(chǎn)品發(fā)表的科研?獻?NatNanotechnol.2021Jul;16(7):830-839.?IntJMolMed.2021Jan;47(1):151-160.?JCancerResClinOncol.2020Nov;146(11):2871-2883.?IrJMedSci.2022May4.Seemorecustomervalidationsonwww.MedChemEREFERENCES1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE[1].SampsonPB,etal.ThediscoveryofPolo-likekinase4inhibitors:identificationof(1R,2S).2-(3-((E).4-(((cis).2,6-dimethylmorpholino)methyl)styryl).1H.indazol-6-yl)-5?'-methoxyspiro[cyclopropane-1,3?'-indolin]-2?'-one(CFI-400945)asapotent,orallyactiveantitumoragent.JMedChem.2015Jan8;58(1):147-69.[2].MasonJM,etal.FunctionalcharacterizationofCFI-400945,aPolo-likekinase4inhibitor,asapotentialanticanceragent.CancerCell.2014Aug11;26(2):163-76.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-5895