Licochalcone-B-Standard-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors ? ScreeningLibraries ? Proteinswww.MedChemELicochalconeB(Standard)Cat.No.:HY-N0373RCASNo.:58749-23-8分子式:C??H??O?分子量:286.28作用靶點(diǎn):Amyloid-β;Apoptosis;NOD-likeReceptor(NLR)作用通路:NeuronalSignaling;Apoptosis;Immunology/Inflammation儲(chǔ)存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性 LicochalconeB(Standard)是LicochalconeB的分析標(biāo)準(zhǔn)品。本產(chǎn)品用于研究及分析應(yīng)用。LicochalconeB是從Glycyrrhizauralensis根中提取的。LicochalconeB抑制淀粉樣蛋白β(amyloidβ;Aβ42)自聚集作用(IC50=2.16μM)并分解預(yù)先形成的Aβ42原纖維，通過螯合金屬離子減少金REFERENCESCaoY,etal.LicochalconeB,achalconederivativefromGlycyrrhizainflata,asamultifunctionalagentforthetreatmentofAlzheimer'sdisease.NatProdRes.2018Oct22:1-4.Jun-ichiFurusawa,etal.Glycyrrhizainflata-derivedchalcones,LicochalconeA,LicochalconeBandLicochalconeD,inhibitphosphorylationofNF-kappaBp65inLPSsignalingpathway.IntImmunopharmacol.2009Apr;9(4):499-507.Ha-NaOh,etal.LicochalconeBinhibitsgrowthandinducesapoptosisofhumannon-small-celllungcancercellsbydualtargetingofEGFRandMET.Phytomedicine.2019Oct;63:153014.QiangLi,etal.LicochalconeBspecificallyinhibitstheNLRP3inflammasomebydisruptingNEK7-NLRP3interaction.EMBORep.2022Feb3;23(2):e53499.TengH,etal.HepatoprotectiveeffectsoflicochalconeBoncarbontetrachloride-inducedlivertoxicityinmice.IranJBasicMedSci.2016Aug;19(8):910-915.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792/p>