Vardenafil-dihydrochloride-Standard-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors ? ScreeningLibraries ? Proteinswww.MedChemEVardenafil(dihydrochloride)(Standard)Cat.No.:HY-B0442CRCASNo.:224789-15-5分子式:C??H??Cl?N?O?S分子量:561.52作用靶點(diǎn):EndogenousMetabolite;Phosphodiesterase(PDE)作用通路:MetabolicEnzyme/Protease儲存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性Vardenafil(dihydrochloride)(Standard)是Vardenafil(dihydrochloride)的分析標(biāo)準(zhǔn)品。本產(chǎn)品用于研究及分析應(yīng)用。Vardenafildihydrochloride是一種具有高選擇性和口服活性的磷酸二酯酶5(PDE5)抑制劑，IC50為0.7nM。Vardenafildihydrochloride對PDE1、PDE6的IC50分IC50&TargetIC50:0.7nM(PDE5);180nM(PDE1);11nM(PDE6);>1000nM(PDE3,PDE4)[1]REFERENCESAshourAE,etal.Vardenafildihydrochloride.ProfilesDrugSubstExcipRelatMethodol.2014;39:515-544.SaenzdeTejadaI,etal.ThephosphodiesteraseinhibitoryselectivityandtheinvitroandinvivopotencyofthenewPDE5inhibitorvardenafil.IntJImpotRes.2001;13(5):282-290.GresserU,etal.Erectiledysfunction:comparisonofefficacyandsideeffectsofthePDE-5inhibitorssildenafil,vardenafilandtadalafil--reviewoftheliterature.EurJMedRes.2002Oct29.7(10):435-46.OudotA,etal.CombinationofBAY60-4552andvardenafilexertsproerectilefacilitatoreffectsinratswithcavernousnerveinjury:aproofofconceptstudyforthetreatmentofphosphodiesterasetype5inhibitorfailure.EurUrol.2011Nov.60(5):1020-6.AhmedN,etal.Hepatoprotectiveroleofvardenafilagainstexperimentallyinducedhepatitisinmice.JBiochemMolToxicol.2017Mar.31(3).BódiB,etal.Long-TermPDE-5AInhibitionImprovesMyofilamentFunctioninLeftandRightVentricularCardiomyocytesthroughPartiallyDifferentMechanismsinDiabeticRatHearts.Antioxidants(Basel).2021Nov6.10(11):1776.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-37