ThTh表面標(biāo)志實(shí)用教案

1、會(huì)計(jì)學(xué)1Th Th 表面表面(biomin)標(biāo)志標(biāo)志第一頁(yè)，共40頁(yè)。第1頁(yè)/共39頁(yè)第二頁(yè)，共40頁(yè)。第2頁(yè)/共39頁(yè)第三頁(yè)，共40頁(yè)。Immunol. Rev. 182:207, 2001第3頁(yè)/共39頁(yè)第四頁(yè)，共40頁(yè)。Th1/Th2/Th17 in diseaseAgent/DiseaseHostResponseOutcomeLeishmaniasisMTh1CureTh2ExacerbationLeprosyHTh1TuberculoidTh2LepromatousRA/MSHTh1Th1 cells in lesionHTh17Th17 in lesionsAllergyHTh2T

2、h2 cytokines in lesionMTh17Induces PMNAc GVHDMTh1Th1 cytokines Chr GVHDMTh2Th2 cytokines第4頁(yè)/共39頁(yè)第五頁(yè)，共40頁(yè)。第5頁(yè)/共39頁(yè)第六頁(yè)，共40頁(yè)。Nature Rev. Immunol. 3:984, 2003第6頁(yè)/共39頁(yè)第七頁(yè)，共40頁(yè)。第7頁(yè)/共39頁(yè)第八頁(yè)，共40頁(yè)。第8頁(yè)/共39頁(yè)第九頁(yè)，共40頁(yè)。Signaling molecules and transcription factors important in Th1/Th2 differentiationAnnu. Rev Imm

3、unol. 21:713, 2003第9頁(yè)/共39頁(yè)第十頁(yè)，共40頁(yè)。Knockout mice that have defects in Th1 development:IFN-, IFN-R, IL-12, IL-12R, Stat4, IRF-1, ICSBP, T-betIL-12 is necessary for IFN- production, and IFN- is necessaryfor the induction of IL-12 responsiveness (acts via induction of T-bet)-stimulates expression of th

4、e IL-12R chain (signal transduction) IL-4 and IFN-are mutually antagonistic in Th1/Th2 development Source of IL-12: dendritic cells, macrophages. Certain pathogens stimulate secretion of large amounts of IL-12 by DC and macrophagesSource of IFN-:NK cells, Th1 cells第10頁(yè)/共39頁(yè)第十一頁(yè)，共40頁(yè)。Knockout mice th

5、at have defects in Th2 development:IL-4, IL-13, IL-4R, Stat6GATA-3 antisense blocks Th2 developmentSource of IL-4Was thought to be either mast cells or CD4+ NK1.1+ T cells - but neither one was provenNow thought to come from developing Th2 cells - under the influence of IL-6, although IL-6 KO mice c

6、an still make some Th2 responses.It is possible that Th2 differentiation is the default pathway in the absence of IL-12第11頁(yè)/共39頁(yè)第十二頁(yè)，共40頁(yè)。Science 260:547, 1993第12頁(yè)/共39頁(yè)第十三頁(yè)，共40頁(yè)。第13頁(yè)/共39頁(yè)第十四頁(yè)，共40頁(yè)。Annu. Rev. Immunol 17:701, 1999Stat6第14頁(yè)/共39頁(yè)第十五頁(yè)，共40頁(yè)。第15頁(yè)/共39頁(yè)第十六頁(yè)，共40頁(yè)。第16頁(yè)/共39頁(yè)第十七頁(yè)，共40頁(yè)。第17頁(yè)/共39頁(yè)第

7、十八頁(yè)，共40頁(yè)。第18頁(yè)/共39頁(yè)第十九頁(yè)，共40頁(yè)。Nature 44: 235 (2006) 第19頁(yè)/共39頁(yè)第二十頁(yè)，共40頁(yè)。第20頁(yè)/共39頁(yè)第二十一頁(yè)，共40頁(yè)。Annu. Rev. Immunol. 1997. 15:297-322.Antigen dose influences Th1/Th2 developmentVery high and very low dose leads to Th2 responseIntermediate dose leads to Th1 responseSame pattern is not always seen in complex

8、antigens第21頁(yè)/共39頁(yè)第二十二頁(yè)，共40頁(yè)。Role of DC subsets and antigen dose in the differentiation of Th1 or Th2 cellsJ. Exp Med. 197:101. 2003第22頁(yè)/共39頁(yè)第二十三頁(yè)，共40頁(yè)。第23頁(yè)/共39頁(yè)第二十四頁(yè)，共40頁(yè)。New data suggest thatOX40L may play a rolein inducing inflammatorycytokines (TNF)J. Exp. Med. 202:1213. 2005第24頁(yè)/共39頁(yè)第二十五頁(yè)，共40頁(yè)。第

9、25頁(yè)/共39頁(yè)第二十六頁(yè)，共40頁(yè)。第26頁(yè)/共39頁(yè)第二十七頁(yè)，共40頁(yè)。第27頁(yè)/共39頁(yè)第二十八頁(yè)，共40頁(yè)。第28頁(yè)/共39頁(yè)第二十九頁(yè)，共40頁(yè)。J. Immunol. 171:6323, 2003第29頁(yè)/共39頁(yè)第三十頁(yè)，共40頁(yè)。第30頁(yè)/共39頁(yè)第三十一頁(yè)，共40頁(yè)。第31頁(yè)/共39頁(yè)第三十二頁(yè)，共40頁(yè)。第32頁(yè)/共39頁(yè)第三十三頁(yè)，共40頁(yè)。第33頁(yè)/共39頁(yè)第三十四頁(yè)，共40頁(yè)。Also induces FoxP3 expression in CD4+ CD25- T cellsJI 176:6752, 2006第34頁(yè)/共39頁(yè)第三十五頁(yè)，共40頁(yè)。Seminars in Immunology 16:104, 2004第35頁(yè)/共39頁(yè)第三十六頁(yè)，共40頁(yè)。Nature Immunol. 2:816, 2001第36頁(yè)/共39頁(yè)第三十七頁(yè)，共40頁(yè)。Nat. Rev. Immunol. 6:613,