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1、 32 生理學(xué)報(bào) Acta Physiologica Sinica, February 25, 2005, 57(1: 27-32 10 2+ KV 上調(diào) 結(jié)合 L-VDC 的下調(diào)可使 Ca 內(nèi)流減少, 這 可能也是失重下主要阻力性動(dòng)脈血管功能與結(jié)構(gòu)下 調(diào)的電生理學(xué)自體調(diào)節(jié)機(jī)制之一。但 L-VDC 電流密 度的降低是由于通道表達(dá)的降低還是單個(gè)通道功能 的改變引起還有待進(jìn)一步闡明。 參考文獻(xiàn) 1 Zhang LF ( 張立藩,Yu ZB, Ma J, Mao QW. Peripheral effector mechanism hypothesis on cardiovascular dysfun

2、ction after spaceflight. Prog Physiol Sci (生理科學(xué)進(jìn)展 2001; 32(1:13-17 (Chinese, English abstract. 2 Buckey JC, Lane LD, Levine BD, Watenpaugh DE, Wright SJ, Moore WE, Gaffney FA, Blomqvist CG. Orthostatic intolerance after spaceflight. J Appl Physiol 1996; 81(1: 7-18. 3 Looft-Wilson RC,Gisolfi CV. Rat

3、small mesenteric artery function after hindlimb suspension. J Appl Physiol 2000; 88: 1199-1206. 4 Ma J, Zhang LN, Zhang LF. Vasoconstrictor responsiveness of hind body vascular beds is diminished in tail-suspended rats. J Gravit Physiol 2000; 7:153-154. 5 Delp MD, Colleran PN, Wilkerson MK, McCurdy

4、MR, Muller-Delp J. Structural and functional remodeling of skeletal muscle microvasculature is induced by simulated microgravity. Am J Physiol Heart Circ Physiol 2000; 278: 1866-1873. 6 Mao QW, Zhang LF, Ma J. Observation on arteriolar network structure in soleus of tail-suspended rats. J Gravit Phy

5、siol 1997; 4:129-130. 7 8 Zhang LF. Invited review: Vascular adaptation to microgravity: what have we learned? J Appl Physiol 2001; 91: 2415-2430. Somlyo AP, Somlyo AV. Signal transduction and regulation in smooth muscle. Nature 1994; 372: 231-236. 9 Jackson WF. Ion channels and vascular tone. Hyper

6、tension 2000; 35:173-178. 10 Fu ZJ (付兆君, Cheng HW, Zhang LF, Ma J. Changes in potassium currents of vascular smooth muscle cells isolated from hindquarter arteries of rats after 4 weeks simulated weightlessness. Acta Physiol Sin (生理學(xué)報(bào) 2002; 54: 525530 (Chinese, English abstract . 11 Morey-Holton ER,

7、Globus RK. Hindlimb unloading rodent model: technical aspects. J Appl Physiol 2002; 92:1367-1377. 12 He JQ (何加強(qiáng), Qu JH, Zheng YF, Wang XF. Characteristics of voltage-dependent Ca2+ channels in smooth muscle cell membrane of visceral resistance vessel in SHRsp.Acta Biophys Sin (生物物理學(xué)報(bào) 1998; 14(3: 418

8、-427 (Chinese, English abstract. 13 Cox RH ,Rusch NJ . New expression profiles of voltagegated ion channels in arteries exposed to high blood pressure. Microcirculation 2002 ;9: 243-257. 14 Zhang LF, Zhang LN, Meng QJ, Fu ZJ. Research in differential adaptations of vessels to microgravity. 23rd Annu

9、al International Gravitational Physiology Meeting; 2002 June, Karolinska Institute, Sweden. ESA SP-501. J Gravit Physiol 2002; 9(1: P55-P58. 15 Yuan JX, Rubin LJ. Altered expression and function of Kv channels in primary pulmonary hypertension. In Archer and Rusch (eds. Potassium Channels in Cardiovascular Biology. New York: Kluwer Academic/ Plenum Publishers, 2001, 821836. 16 Fu ZJ, Xie MJ, Zhang LF, Cheng HW, Ma J. Differential activation of po

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